diff --git a/targets/TARGET_STM/TARGET_STM32F3/TARGET_STM32F303xE/TARGET_NUCLEO_F303ZE/PinNames.h b/targets/TARGET_STM/TARGET_STM32F3/TARGET_STM32F303xE/TARGET_NUCLEO_F303ZE/PinNames.h
index d1c76fab8f8..caaad197767 100644
--- a/targets/TARGET_STM/TARGET_STM32F3/TARGET_STM32F303xE/TARGET_NUCLEO_F303ZE/PinNames.h
+++ b/targets/TARGET_STM/TARGET_STM32F3/TARGET_STM32F303xE/TARGET_NUCLEO_F303ZE/PinNames.h
@@ -355,6 +355,9 @@ typedef enum {
 #define LED3     PB_14  // LD3 [Red]
 #define BUTTON1  PC_13  // USER_Btn [B1]
 
+// USB
+#define USB_PULLUP_CONTROL  PG_6 // USB_Disconnect in the schematics
+
 #ifdef __cplusplus
 }
 #endif
diff --git a/targets/TARGET_STM/TARGET_STM32F3/TARGET_STM32F303xE/system_clock.c b/targets/TARGET_STM/TARGET_STM32F3/TARGET_STM32F303xE/system_clock.c
index 05873573cbe..863fb9c281a 100644
--- a/targets/TARGET_STM/TARGET_STM32F3/TARGET_STM32F303xE/system_clock.c
+++ b/targets/TARGET_STM/TARGET_STM32F3/TARGET_STM32F303xE/system_clock.c
@@ -93,7 +93,6 @@ uint8_t SetSysClock_PLL_HSE(uint8_t bypass)
 {
     RCC_ClkInitTypeDef RCC_ClkInitStruct;
     RCC_OscInitTypeDef RCC_OscInitStruct;
-    RCC_PeriphCLKInitTypeDef RCC_PeriphClkInit;
 
     /* Enable HSE oscillator and activate PLL with HSE as source */
     RCC_OscInitStruct.OscillatorType      = RCC_OSCILLATORTYPE_HSE;
@@ -120,11 +119,14 @@ uint8_t SetSysClock_PLL_HSE(uint8_t bypass)
         return 0; // FAIL
     }
 
+#if DEVICE_USBDEVICE
+    RCC_PeriphCLKInitTypeDef RCC_PeriphClkInit;
     RCC_PeriphClkInit.PeriphClockSelection = RCC_PERIPHCLK_USB;
     RCC_PeriphClkInit.USBClockSelection = RCC_USBCLKSOURCE_PLL_DIV1_5;
     if (HAL_RCCEx_PeriphCLKConfig(&RCC_PeriphClkInit) != HAL_OK) {
         return 0; // FAIL
     }
+#endif
 
     /* Output clock on MCO1 pin(PA8) for debugging purpose */
     //if (bypass == 0)
@@ -144,7 +146,6 @@ uint8_t SetSysClock_PLL_HSI(void)
 {
     RCC_ClkInitTypeDef RCC_ClkInitStruct;
     RCC_OscInitTypeDef RCC_OscInitStruct;
-    RCC_PeriphCLKInitTypeDef RCC_PeriphClkInit;
 
     /* Enable HSI oscillator and activate PLL with HSI as source */
     RCC_OscInitStruct.OscillatorType      = RCC_OSCILLATORTYPE_HSI | RCC_OSCILLATORTYPE_HSE;
@@ -169,11 +170,14 @@ uint8_t SetSysClock_PLL_HSI(void)
         return 0; // FAIL
     }
 
+#if DEVICE_USBDEVICE
+    RCC_PeriphCLKInitTypeDef RCC_PeriphClkInit;
     RCC_PeriphClkInit.PeriphClockSelection = RCC_PERIPHCLK_USB;
     RCC_PeriphClkInit.USBClockSelection = RCC_USBCLKSOURCE_PLL_DIV1_5;
     if (HAL_RCCEx_PeriphCLKConfig(&RCC_PeriphClkInit) != HAL_OK) {
         return 0; // FAIL
     }
+#endif
 
     /* Output clock on MCO1 pin(PA8) for debugging purpose */
     //HAL_RCC_MCOConfig(RCC_MCO, RCC_MCOSOURCE_HSI, RCC_MCO_DIV1); // 8 MHz
diff --git a/targets/TARGET_STM/USBPhyHw.h b/targets/TARGET_STM/USBPhyHw.h
index fc3f8c64a6c..3bce84f633e 100644
--- a/targets/TARGET_STM/USBPhyHw.h
+++ b/targets/TARGET_STM/USBPhyHw.h
@@ -43,8 +43,10 @@
 
 #if MBED_CONF_TARGET_USB_SPEED == USE_USB_NO_OTG
 
-#if defined(TARGET_STM32F1) || defined(TARGET_STM32F3) || defined(TARGET_STM32L1) || defined(TARGET_STM32WB) || defined(TARGET_STM32G4)
+#if defined(TARGET_STM32F1) || defined(TARGET_STM32L1) || defined(TARGET_STM32WB) || defined(TARGET_STM32G4)
 #define USBHAL_IRQn  USB_LP_IRQn
+#elif defined(TARGET_STM32F3)
+#define USBHAL_IRQn  USB_LP_CAN_RX0_IRQn
 #elif defined(TARGET_STM32L5)
 #define USBHAL_IRQn  USB_FS_IRQn
 #else
diff --git a/targets/TARGET_STM/USBPhy_STM32.cpp b/targets/TARGET_STM/USBPhy_STM32.cpp
index 7f0c8d31420..28068ee972d 100644
--- a/targets/TARGET_STM/USBPhy_STM32.cpp
+++ b/targets/TARGET_STM/USBPhy_STM32.cpp
@@ -192,7 +192,7 @@ USBPhyHw::~USBPhyHw()
 
 }
 
-#if defined(TARGET_STM32F1) || defined(SYSCFG_PMC_USB_PU)
+#if defined(TARGET_STM32F1) || defined(TARGET_STM32F3) || defined(SYSCFG_PMC_USB_PU)
 
 #include "drivers/DigitalOut.h"
 
@@ -203,9 +203,14 @@ void USB_reenumerate()
     LL_SYSCFG_DisableUSBPullUp();
     wait_us(10000); // 10ms
     LL_SYSCFG_EnableUSBPullUp();
+#elif defined(USB_PULLUP_CONTROL)
+    mbed::DigitalOut usb_dp_pin(USB_PULLUP_CONTROL, 0);
+    wait_us(1000);
+    usb_dp_pin = 1;
+    wait_us(1000);
 #else
     // Force USB_DP pin (with external pull up) to 0
-    mbed::DigitalOut usb_dp_pin(USB_DP, 0) ;
+    mbed::DigitalOut usb_dp_pin(USB_DP, 0);
     wait_us(10000); // 10ms
 #endif
 }
@@ -295,7 +300,7 @@ void USBPhyHw::init(USBPhyEvents *events)
 
     map = PinMap_USB_FS;
 
-#if defined(TARGET_STM32F1) || defined(SYSCFG_PMC_USB_PU)
+#if defined(TARGET_STM32F1) || defined(TARGET_STM32F3) || defined(SYSCFG_PMC_USB_PU)
     // USB_DevConnect is empty
     USB_reenumerate();
 #endif
@@ -418,7 +423,7 @@ void USBPhyHw::connect()
     // Initializes the USB controller registers
     USB_DevInit(hpcd.Instance, hpcd.Init); // hpcd.Init not used
 
-#if defined(TARGET_STM32F1) || defined(SYSCFG_PMC_USB_PU)
+#if defined(TARGET_STM32F1) || defined(TARGET_STM32F3) || defined(SYSCFG_PMC_USB_PU)
     // USB_DevConnect is empty
     USB_reenumerate();
 #endif
diff --git a/targets/targets.json b/targets/targets.json
index 15bce670951..fb651436dbd 100644
--- a/targets/targets.json
+++ b/targets/targets.json
@@ -1718,6 +1718,9 @@
         "detect_code": [
             "0747"
         ],
+        "device_has_add": [
+            "USBDEVICE"
+        ],
         "device_name": "STM32F303ZETx"
     },
     "MCU_STM32F334x8": {