diff --git a/src/capture-announcements.ts b/src/capture-announcements.ts
index f6b2c0e..46095fb 100644
--- a/src/capture-announcements.ts
+++ b/src/capture-announcements.ts
@@ -179,7 +179,7 @@ export default function CaptureAnnouncements(options: Options): Restore {
     // prettier-ignore
     const cleanups: Restore[] = [
         interceptMethod(Element.prototype, 'setAttribute', onSetAttribute),
-        interceptMethod(Element.prototype, 'removeAttribute', onRemoveAttribute),
+        interceptMethod(Element.prototype, 'removeChild', onRemoveChild),
         interceptMethod(Element.prototype, 'insertAdjacentElement', onInsertAdjacent),
         interceptMethod(Element.prototype, 'insertAdjacentHTML', onInsertAdjacent),
         interceptMethod(Element.prototype, 'insertAdjacentText', onInsertAdjacent),
@@ -212,6 +212,25 @@ function onRemoveAttribute(
     }
 }
 
+function onRemoveChild(
+    this: Element,
+    ...args: Parameters<Element['removeChild']>
+) {
+    if (args[0] == null || !isElement(args[0])) return;
+
+    const elementAndItsLiveRegionChildren = [
+        args[0],
+        ...args[0].querySelectorAll(LIVE_REGION_QUERY),
+    ];
+
+    // Check whether removed element or any of its children were tracked
+    for (const element of elementAndItsLiveRegionChildren) {
+        if (liveRegions.has(element)) {
+            liveRegions.delete(element);
+        }
+    }
+}
+
 function trimWhiteSpace(text: string): string | null {
     const trimmed = text.trim().replace(WHITE_SPACE_REGEXP, ' ');
     return trimmed.length > 0 ? trimmed : null;
diff --git a/test/capture-announcements.test.ts b/test/capture-announcements.test.ts
index e181f3e..d1e8554 100644
--- a/test/capture-announcements.test.ts
+++ b/test/capture-announcements.test.ts
@@ -416,4 +416,35 @@ describe('element tracking', () => {
         expect(liveRegions.size).toBe(0);
         expect(liveRegions.has(element)).toBe(false);
     });
+
+    test('element is removed from tracked elements when unmounted', () => {
+        element.setAttribute('role', 'status');
+        appendToRoot(element);
+        element.textContent = 'Hello world';
+
+        expect(liveRegions.size).toBe(1);
+        expect(liveRegions.has(element)).toBe(true);
+
+        element.parentElement!.removeChild(element);
+
+        expect(liveRegions.size).toBe(0);
+        expect(liveRegions.has(element)).toBe(false);
+    });
+
+    test('element is removed from tracked elements when ancestor is unmounted', () => {
+        const child = document.createElement('div');
+        child.setAttribute('role', 'status');
+        element.appendChild(child);
+
+        appendToRoot(element);
+        child.textContent = 'Hello world';
+
+        expect(liveRegions.size).toBe(1);
+        expect(liveRegions.has(child)).toBe(true);
+
+        element.parentElement!.removeChild(element);
+
+        expect(liveRegions.size).toBe(0);
+        expect(liveRegions.has(element)).toBe(false);
+    });
 });