diff --git a/extensions/dicom-segmentation/src/components/SegmentationPanel/SegmentationPanel.js b/extensions/dicom-segmentation/src/components/SegmentationPanel/SegmentationPanel.js
index 25fdfd35b14..02ece632fae 100644
--- a/extensions/dicom-segmentation/src/components/SegmentationPanel/SegmentationPanel.js
+++ b/extensions/dicom-segmentation/src/components/SegmentationPanel/SegmentationPanel.js
@@ -155,7 +155,9 @@ const SegmentationPanel = ({
 
     const brushStackState = getBrushStackState();
     brushStackState.activeLabelmapIndex = newLabelmapIndex;
-    setState(state => ({ ...state, selectedSegmentation }));
+    if (selectedSegmentation) {
+      setState(state => ({ ...state, selectedSegmentation }));
+    }
 
     refreshViewports();
 
@@ -189,10 +191,9 @@ const SegmentationPanel = ({
       'extensiondicomsegmentationsegloaded',
       refreshSegmentations
     );
-
     document.addEventListener(
-      'extensiondicomsegmentationsegloadingfailed',
-      cleanSegmentationComboBox
+      'extensiondicomsegmentationsegselected',
+      updateSegmentationComboBox
     );
 
     /*
@@ -213,8 +214,8 @@ const SegmentationPanel = ({
         refreshSegmentations
       );
       document.removeEventListener(
-        'extensiondicomsegmentationsegloadingfailed',
-        cleanSegmentationComboBox
+        'extensiondicomsegmentationsegselected',
+        updateSegmentationComboBox
       );
       cornerstoneTools.store.state.enabledElements.forEach(enabledElement =>
         enabledElement.removeEventListener(
@@ -225,6 +226,15 @@ const SegmentationPanel = ({
     };
   }, [activeIndex, viewports]);
 
+  const updateSegmentationComboBox = (e) => {
+    const index = e.detail.activatedLabelmapIndex;
+    if (index !== -1) {
+      setState(state => ({ ...state, selectedSegmentation: index }));
+    } else {
+      cleanSegmentationComboBox();
+    }
+  }
+
   const cleanSegmentationComboBox = () => {
     setState(state => ({
       ...state,
@@ -233,6 +243,7 @@ const SegmentationPanel = ({
       labelMapList: [],
       segmentList: [],
       isDisabled: true,
+      selectedSegmentation: -1,
     }));
   }
 
@@ -298,7 +309,7 @@ const SegmentationPanel = ({
     );
 
     const filteredReferencedSegDisplaysets = referencedSegDisplaysets.filter(
-      (segDisplay => segDisplay.loadError !== true && segDisplay.isLoaded));
+      (segDisplay => segDisplay.loadError !== true));
 
     return filteredReferencedSegDisplaysets.map((displaySet, index) => {
       const {
diff --git a/extensions/dicom-segmentation/src/components/SegmentationSelect.js b/extensions/dicom-segmentation/src/components/SegmentationSelect.js
index 52b2ca8f043..4d988d99a6c 100644
--- a/extensions/dicom-segmentation/src/components/SegmentationSelect.js
+++ b/extensions/dicom-segmentation/src/components/SegmentationSelect.js
@@ -3,7 +3,7 @@ import Select from 'react-select';
 
 const SegmentationSelect = ({ value, formatOptionLabel, options }) => (
   <Select
-    value={value}
+    value={value === undefined ? null : value}
     formatOptionLabel={formatOptionLabel}
     styles={segmentationSelectStyles}
     options={options}
diff --git a/extensions/dicom-segmentation/src/getOHIFDicomSegSopClassHandler.js b/extensions/dicom-segmentation/src/getOHIFDicomSegSopClassHandler.js
index 9142fc8a198..8dfc2c89cf1 100644
--- a/extensions/dicom-segmentation/src/getOHIFDicomSegSopClassHandler.js
+++ b/extensions/dicom-segmentation/src/getOHIFDicomSegSopClassHandler.js
@@ -55,6 +55,7 @@ export default function getSopClassHandlerModule({ servicesManager }) {
         referencedDisplaySetUID: null, // Assigned when loaded.
         labelmapIndex: null, // Assigned when loaded.
         isLoaded: false,
+        loadError: false,
         hasOverlapping: false,
         SeriesDate,
         SeriesTime,
@@ -68,7 +69,6 @@ export default function getSopClassHandlerModule({ servicesManager }) {
       };
 
       segDisplaySet.load = async function(referencedDisplaySet, studies) {
-        segDisplaySet.isLoading = true;
         segDisplaySet.isLoaded = true;
         const { StudyInstanceUID } = referencedDisplaySet;
         const segArrayBuffer = await DicomLoaderService.findDicomDataPromise(
@@ -129,7 +129,6 @@ export default function getSopClassHandlerModule({ servicesManager }) {
         }
       };
 
-      segDisplaySet.isLoading = false;
       return segDisplaySet;
     },
   };
diff --git a/extensions/dicom-segmentation/src/getSourceDisplaySet.js b/extensions/dicom-segmentation/src/getSourceDisplaySet.js
index c9612322a37..afa423f0c8c 100644
--- a/extensions/dicom-segmentation/src/getSourceDisplaySet.js
+++ b/extensions/dicom-segmentation/src/getSourceDisplaySet.js
@@ -1,90 +1,16 @@
 import setActiveLabelmap from './utils/setActiveLabelMap';
-import { classes } from '@ohif/core';
-
-const { ImageSet } = classes;
+import { getReferencedDisplaySet } from '../../../platform/core/src/classes/metadata/StudyMetadata.js';
 
 export default function getSourceDisplaySet(studies, segDisplaySet, activateLabelMap = true, onDisplaySetLoadFailureHandler) {
-  const referencedDisplaySet = _getReferencedDisplaySet(segDisplaySet, studies);
+  const referencedDisplaySet = getReferencedDisplaySet(segDisplaySet, studies);
 
+  let activatedLabelmapPromise;
   if (activateLabelMap) {
-    setActiveLabelmap(referencedDisplaySet, studies, segDisplaySet, undefined, onDisplaySetLoadFailureHandler);
+    activatedLabelmapPromise = setActiveLabelmap(referencedDisplaySet, studies, segDisplaySet, undefined, onDisplaySetLoadFailureHandler);
   }
 
-  return referencedDisplaySet;
-}
-
-const _getReferencedDisplaySet = (segDisplaySet, studies) => {
-  let allDisplaySets = [];
-
-  studies.forEach(study => {
-    allDisplaySets = allDisplaySets.concat(study.displaySets);
-  });
-
-  const otherDisplaySets = allDisplaySets.filter(
-    ds => ds.displaySetInstanceUID !== segDisplaySet.displaySetInstanceUID
-  );
-
-  const { metadata } = segDisplaySet;
-
-  let referencedSeriesInstanceUIDs;
-
-  if (metadata.ReferencedSeriesSequence) {
-    const ReferencedSeriesSequence = _toArray(
-      metadata.ReferencedSeriesSequence
-    );
-
-    referencedSeriesInstanceUIDs = ReferencedSeriesSequence.map(
-      ReferencedSeries => ReferencedSeries.SeriesInstanceUID
-    );
-  } else {
-    const { PerFrameFunctionalGroupsSequence } = metadata;
-
-    let SourceImageSequence;
-
-    if (metadata.SourceImageSequence) {
-      SourceImageSequence = metadata.SourceImageSequence;
-    } else {
-      const firstFunctionalGroups = _toArray(
-        PerFrameFunctionalGroupsSequence
-      )[0];
-      const { DerivationImageSequence } = firstFunctionalGroups;
-
-      SourceImageSequence = DerivationImageSequence;
-    }
-
-    const firstSourceImage = _toArray(SourceImageSequence)[0];
-
-    const { ReferencedSOPInstanceUID } = firstSourceImage;
-
-    referencedSeriesInstanceUIDs = _findReferencedSeriesInstanceUIDsFromSOPInstanceUID(
-      otherDisplaySets,
-      ReferencedSOPInstanceUID
-    );
-  }
-
-  const referencedDisplaySet = otherDisplaySets.find(ds =>
-    referencedSeriesInstanceUIDs.includes(ds.SeriesInstanceUID)
-  );
-
-  return referencedDisplaySet;
-};
-
-const _findReferencedSeriesInstanceUIDsFromSOPInstanceUID = (
-  displaySets,
-  SOPInstanceUID
-) => {
-  const imageSets = displaySets.filter(ds => ds instanceof ImageSet);
-
-  for (let i = 0; i < imageSets.length; i++) {
-    const { images } = imageSets[i];
-    for (let j = 0; j < images.length; j++) {
-      if (images[j].SOPInstanceUID === SOPInstanceUID) {
-        return [images[j].getData().metadata.SeriesInstanceUID];
-      }
-    }
+  return {
+    referencedDisplaySet : referencedDisplaySet,
+    activatedLabelmapPromise : activatedLabelmapPromise
   }
-};
-
-function _toArray(arrayOrObject) {
-  return Array.isArray(arrayOrObject) ? arrayOrObject : [arrayOrObject];
 }
diff --git a/extensions/dicom-segmentation/src/utils/setActiveLabelMap.js b/extensions/dicom-segmentation/src/utils/setActiveLabelMap.js
index 3644d861abb..1bda8d2e281 100644
--- a/extensions/dicom-segmentation/src/utils/setActiveLabelMap.js
+++ b/extensions/dicom-segmentation/src/utils/setActiveLabelMap.js
@@ -47,23 +47,15 @@ export default async function setActiveLabelmap(
     return labelmapIndex;
   }
 
-  if (displaySet.isLoading) {
-    return activeLabelmapIndex;
-  }
-
   if (!displaySet.isLoaded) {
     try {
       await displaySet.load(referencedDisplaySet, studies);
     } catch (error) {
       displaySet.isLoaded = false;
-      displaySet.isLoading = false;
       displaySet.loadError = true;
       onDisplaySetLoadFailure(error);
 
-      const event = new CustomEvent('extensiondicomsegmentationsegloadingfailed');
-      document.dispatchEvent(event);
-
-      return activeLabelmapIndex;
+      return -1;
     }
   }
 
@@ -74,8 +66,11 @@ export default async function setActiveLabelmap(
 
   // This might have just been created, so need to use the non-cached value.
   state = cornerstoneTools.getModule('segmentation').state;
+
   brushStackState = state.series[firstImageId];
-  brushStackState.activeLabelmapIndex = labelmapIndex;
+  if (brushStackState) {
+    brushStackState.activeLabelmapIndex = labelmapIndex;
+  }
 
   refreshViewports();
   callback();
diff --git a/platform/core/src/classes/metadata/StudyMetadata.js b/platform/core/src/classes/metadata/StudyMetadata.js
index e05701f8a69..2e6531f9ad1 100644
--- a/platform/core/src/classes/metadata/StudyMetadata.js
+++ b/platform/core/src/classes/metadata/StudyMetadata.js
@@ -13,7 +13,7 @@ import { isDisplaySetReconstructable, isSpacingUniform } from '../../utils/isDis
 import errorHandler from '../../errorHandler';
 import isLowPriorityModality from '../../utils/isLowPriorityModality';
 
-export class StudyMetadata extends Metadata {
+class StudyMetadata extends Metadata {
   constructor(data, uid) {
     super(data, uid);
     // Initialize Private Properties
@@ -252,20 +252,7 @@ export class StudyMetadata extends Metadata {
     if (referencedSeriesInstanceUID) {
       filteredDerivedDisplaySets = filteredDerivedDisplaySets.filter(
         displaySet => {
-          if (!displaySet.metadata.ReferencedSeriesSequence) {
-            return false;
-          }
-
-          const ReferencedSeriesSequence = Array.isArray(
-            displaySet.metadata.ReferencedSeriesSequence
-          )
-            ? displaySet.metadata.ReferencedSeriesSequence
-            : [displaySet.metadata.ReferencedSeriesSequence];
-
-          return ReferencedSeriesSequence.some(
-            ReferencedSeries =>
-              ReferencedSeries.SeriesInstanceUID === referencedSeriesInstanceUID
-          );
+          return getReferencedDisplaySet(displaySet, [this]).SeriesInstanceUID === referencedSeriesInstanceUID;
         }
       );
     }
@@ -273,7 +260,7 @@ export class StudyMetadata extends Metadata {
     if (referencedFrameOfReferenceUID) {
       filteredDerivedDisplaySets = filteredDerivedDisplaySets.filter(
         displaySet =>
-          displaySet.ReferencedFrameOfReferenceUID ===
+          displaySet.FrameOfReferenceUID ===
           referencedFrameOfReferenceUID
       );
     }
@@ -916,3 +903,184 @@ function _getDisplaySetFromSopClassModule(
   }
   return displaySet;
 }
+
+/**
+  * Returns the source display set of the derivated display set.
+  * @param {object} derivatedDisplaySet
+  * @param {array[StudyMetadata]} studies
+  * @return {object} source display set.
+  */
+function getReferencedDisplaySet(derivatedDisplaySet, studies) {
+  let allDisplaySets = [];
+
+  studies.forEach(study => {
+    allDisplaySets = allDisplaySets.concat(study.displaySets);
+  });
+
+  const otherDisplaySets = allDisplaySets.filter(
+    ds => ds.displaySetInstanceUID !== derivatedDisplaySet.displaySetInstanceUID
+  );
+
+  const { metadata } = derivatedDisplaySet;
+
+  let referencedSeriesInstanceUIDs = _findReferencedSeriesInstanceUIDsFromSourceImageSequence
+  (metadata, otherDisplaySets);
+
+  let noReferencedSeriesAvailable = !referencedSeriesInstanceUIDs ||
+    referencedSeriesInstanceUIDs.length === 0;
+  if (noReferencedSeriesAvailable) {
+    referencedSeriesInstanceUIDs =
+      _findReferencedSeriesInstanceUIDsFromReferencedSeriesSequence
+        (metadata);
+  }
+
+  noReferencedSeriesAvailable = !referencedSeriesInstanceUIDs ||
+    referencedSeriesInstanceUIDs.length === 0;
+  if (noReferencedSeriesAvailable) {
+    referencedSeriesInstanceUIDs =
+    _findReferencedSeriesInstanceUIDsFromReferencedImageSequence
+        (metadata, otherDisplaySets);
+  }
+
+  const referencedSeriesAvailable = referencedSeriesInstanceUIDs &&
+    referencedSeriesInstanceUIDs.length !== 0;
+  if (referencedSeriesAvailable) {
+    const referencedDisplaySet = otherDisplaySets.find(ds =>
+      referencedSeriesInstanceUIDs.includes(ds.SeriesInstanceUID)
+    );
+    ;
+    return referencedDisplaySet;
+  }
+};
+
+/**
+  * Returns the referenced series instance UIDs by searching the information in the
+  * ReferencedSeriesSequence.
+  * @param {object} derivatedDisplaySet.metadata
+  * @return {array[string]} referenced series instance UIDs.
+  */
+function _findReferencedSeriesInstanceUIDsFromReferencedSeriesSequence (
+  metadata,
+) {
+  if (!metadata.ReferencedSeriesSequence) {
+    return;
+  }
+
+  let referencedSeriesInstanceUIDs;
+  const ReferencedSeriesSequence = _toArray(
+    metadata.ReferencedSeriesSequence
+  );
+
+  referencedSeriesInstanceUIDs = ReferencedSeriesSequence.map(
+    ReferencedSeries => ReferencedSeries.SeriesInstanceUID
+  );
+
+  return referencedSeriesInstanceUIDs;
+};
+
+/**
+  * Returns the referenced series instance UIDs by searching the information in the
+  * ReferencedImageSequence.
+  * @param {object} derivatedDisplaySet.metadata
+  * @param {array[object]} displaysets
+  * @return {array[string]} referenced series instance UIDs.
+  */
+function _findReferencedSeriesInstanceUIDsFromReferencedImageSequence (
+  metadata,
+  displaySets
+) {
+  if (!metadata.ReferencedImageSequence) {
+    return;
+  }
+
+  let referencedSeriesInstanceUIDs;
+  const referencedImageArray = _toArray(metadata.ReferencedImageSequence);
+  for (let i = 0; i < referencedImageArray.length; i++) {
+    const { ReferencedSOPInstanceUID } = referencedImageArray[i];
+
+    referencedSeriesInstanceUIDs = _findReferencedSeriesInstanceUIDsFromSOPInstanceUID(
+      displaySets,
+      ReferencedSOPInstanceUID
+    );
+
+    if (referencedSeriesInstanceUIDs && referencedSeriesInstanceUIDs.length !== 0) {
+      break;
+    }
+  }
+
+  return referencedSeriesInstanceUIDs;
+};
+
+/**
+  * Returns the referenced series instance UIDs by searching the information in the
+  * SourceImageSequence.
+  * @param {object} derivatedDisplaySet.metadata
+  * @param {array[object]} displaysets
+  * @return {array[string]} referenced series instance UIDs.
+  */
+function _findReferencedSeriesInstanceUIDsFromSourceImageSequence (
+  metadata,
+  displaySets
+) {
+  let SourceImageSequence;
+
+  if (metadata.SourceImageSequence) {
+    SourceImageSequence = metadata.SourceImageSequence;
+  } else {
+    const { PerFrameFunctionalGroupsSequence } = metadata;
+    const firstFunctionalGroups = _toArray(
+      PerFrameFunctionalGroupsSequence
+    )[0];
+    const { DerivationImageSequence } = firstFunctionalGroups;
+    SourceImageSequence = DerivationImageSequence;
+  }
+
+  if (!SourceImageSequence) {
+    return;
+  }
+
+  const sourceImageArray = _toArray(SourceImageSequence);
+
+  let referencedSeriesInstanceUIDs;
+  for (let i = 0; i < sourceImageArray.length; i++) {
+    const { ReferencedSOPInstanceUID } = sourceImageArray[i];
+    referencedSeriesInstanceUIDs = _findReferencedSeriesInstanceUIDsFromSOPInstanceUID(
+      displaySets,
+      ReferencedSOPInstanceUID
+    );
+    if (referencedSeriesInstanceUIDs && referencedSeriesInstanceUIDs.length !== 0) {
+      break;
+    }
+  }
+
+  return referencedSeriesInstanceUIDs;
+};
+
+/**
+  * Returns the referenced series instance UIDs by searching the information in the
+  * SOPInstanceUID of the displaySets.
+  * @param {array[object]} displaysets
+  * @param {string} SOPInstanceUID
+  * @return {array[string]} referenced series instance UIDs.
+  */
+function _findReferencedSeriesInstanceUIDsFromSOPInstanceUID (
+  displaySets,
+  SOPInstanceUID
+) {
+  const imageSets = displaySets.filter(ds => ds instanceof ImageSet);
+
+  for (let i = 0; i < imageSets.length; i++) {
+    const { images } = imageSets[i];
+    for (let j = 0; j < images.length; j++) {
+      if (images[j].SOPInstanceUID === SOPInstanceUID) {
+        return [images[j].getData().metadata.SeriesInstanceUID];
+      }
+    }
+  }
+};
+
+function _toArray(arrayOrObject) {
+  return Array.isArray(arrayOrObject) ? arrayOrObject : [arrayOrObject];
+}
+
+export {StudyMetadata, getReferencedDisplaySet};
diff --git a/platform/core/src/utils/loadAndCacheDerivedDisplaySets.js b/platform/core/src/utils/loadAndCacheDerivedDisplaySets.js
index 1cfac4ee74c..d655f15d624 100644
--- a/platform/core/src/utils/loadAndCacheDerivedDisplaySets.js
+++ b/platform/core/src/utils/loadAndCacheDerivedDisplaySets.js
@@ -106,11 +106,11 @@ async function loadAndCacheDerivedDisplaySets(referencedDisplaySet, studies, log
       }
     });
 
-    recentDisplaySet.isLoading = true;
-
     try {
       await recentDisplaySet.load(referencedDisplaySet, studies);
     } catch (error) {
+      recentDisplaySet.isLoaded = false;
+      recentDisplaySet.loadError = true;
       logger.error({ error, message: error.message });
       snackbar.show({
         title: 'Error loading derived display set:',
diff --git a/platform/viewer/src/connectedComponents/ConnectedStudyBrowser.js b/platform/viewer/src/connectedComponents/ConnectedStudyBrowser.js
index 519103c293c..22efaeb125e 100644
--- a/platform/viewer/src/connectedComponents/ConnectedStudyBrowser.js
+++ b/platform/viewer/src/connectedComponents/ConnectedStudyBrowser.js
@@ -61,7 +61,20 @@ const mapDispatchToProps = (dispatch, ownProps) => {
             });
           };
 
-          displaySet = displaySet.getSourceDisplaySet(ownProps.studyMetadata, true, onDisplaySetLoadFailureHandler);
+          const {referencedDisplaySet, activatedLabelmapPromise} = displaySet.getSourceDisplaySet(
+            ownProps.studyMetadata,
+            true,
+            onDisplaySetLoadFailureHandler
+          );
+          displaySet = referencedDisplaySet;
+
+          activatedLabelmapPromise.then((activatedLabelmapIndex) => {
+            const selectionFired = new CustomEvent("extensiondicomsegmentationsegselected", {
+              "detail": {"activatedLabelmapIndex":activatedLabelmapIndex}
+            });
+            document.dispatchEvent(selectionFired);
+          });
+
         } else {
           displaySet = displaySet.getSourceDisplaySet(ownProps.studyMetadata);
         }
diff --git a/platform/viewer/src/connectedComponents/Viewer.js b/platform/viewer/src/connectedComponents/Viewer.js
index 06dc60a9020..d22fa872107 100644
--- a/platform/viewer/src/connectedComponents/Viewer.js
+++ b/platform/viewer/src/connectedComponents/Viewer.js
@@ -433,8 +433,12 @@ const _checkForSeriesInconsistencesWarnings = async function (displaySet, studie
       return warningsList;
     }
 
-    const sourceDisplaySet = displaySet.getSourceDisplaySet(studies, false);
-    const imageIds = sourceDisplaySet.images.map(image => image.getImageId());
+    const { referencedDisplaySet } = displaySet.getSourceDisplaySet(studies, false);
+    if (!referencedDisplaySet) {
+      return warningsList;
+    }
+
+    const imageIds = referencedDisplaySet.images.map(image => image.getImageId());
     if (!imageIds || imageIds.length === 0) {
       return warningsList;
     }
diff --git a/platform/viewer/src/connectedComponents/ViewerMain.js b/platform/viewer/src/connectedComponents/ViewerMain.js
index 04c5e736a63..978b4d52935 100644
--- a/platform/viewer/src/connectedComponents/ViewerMain.js
+++ b/platform/viewer/src/connectedComponents/ViewerMain.js
@@ -153,7 +153,13 @@ class ViewerMain extends Component {
           });
         };
 
-        displaySet = displaySet.getSourceDisplaySet(this.props.studies, true, onDisplaySetLoadFailureHandler);
+        const {referencedDisplaySet} = displaySet.getSourceDisplaySet(
+          this.props.studies,
+          true,
+          onDisplaySetLoadFailureHandler
+        );
+        displaySet = referencedDisplaySet;
+
       } else {
         displaySet = displaySet.getSourceDisplaySet(this.props.studies);
       }