diff --git a/requirements-dev.txt b/requirements-dev.txt
index abd450fce01e..eef50c6b96e1 100644
--- a/requirements-dev.txt
+++ b/requirements-dev.txt
@@ -19,7 +19,7 @@ pylatexenc>=1.4
 ddt>=1.2.0,!=1.4.0,!=1.4.3
 seaborn>=0.9.0
 reno>=3.4.0
-Sphinx>=3.0.0,<5.1
+Sphinx>=3.0.0
 qiskit-sphinx-theme>=1.6
 qiskit-toqm>=0.0.4;platform_machine != 'aarch64' or platform_system != 'Linux'
 sphinx-autodoc-typehints<1.14.0