What is the best practice to compare different eRegulons between Ctrl and KO?

[LILI-0000-0002-8173-7367]

Hello, scenicplus team.

I would like to thank you for development this wonderful tools.

I have several multiome data from control and KO animals. Now I have merge the dataset following the tutorial (https://pycistopic.readthedocs.io/en/latest/Cortex_pycisTopic.html#). Then I generated a scenicplus object and identified enriched eRegulons in each clusters following the step-by-step tutorial (https://scenicplus.readthedocs.io/en/latest/Scenicplus_step_by_step-RTD.html).

I am wondering:

1. What is the best way to identify eRegulons in each clusters from each genotye (now eRegulons were caculated base on both genotype combined)? Or should I subset scenicplus object base on the genotype cell index, then run caculation separately?

2. I would like to identify the different eRegulons between Ctrl and KO. Would you please give me some instructions how to proceed?

I appreciate your time and support!

Best regards,
Li Li