ValueError: Cannot convert float NaN to integer

[Ajeet1699]

Hi,
I am trying to run QC step and it shows error.

Cell In[45], line 14
11 from pycisTopic.qc import *
12 path_to_regions = {'D59':os.path.join(work_dir, 'scATAC/consensus_peak_calling/consensus_regions.bed')}
---> 14 metadata_bc, profile_data_dict = compute_qc_stats(
15 fragments_dict = fragments_dict,
16 tss_annotation = annot,
17 stats=['barcode_rank_plot', 'duplicate_rate', 'insert_size_distribution', 'profile_tss', 'frip'],
18 label_list = None,
19 path_to_regions = path_to_regions,
20 n_cpu = 5,
21 valid_bc = None,
22 n_frag = 100,
23 n_bc = None,
24 tss_flank_window = 1000,
25 tss_window = 10,
26 tss_minimum_signal_window = 100,
27 tss_rolling_window = 10,
28 remove_duplicates = True,
29 _temp_dir = os.path.join(tmp_dir + 'ray_spill'))
31 if not os.path.exists(os.path.join(work_dir, 'scATAC/quality_control')):
32 os.makedirs(os.path.join(work_dir, 'scATAC/quality_control'))

File ~/.local/lib/python3.8/site-packages/pycisTopic/qc.py:1033, in compute_qc_stats(fragments_dict, tss_annotation, stats, label_list, path_to_regions, n_cpu, partition, valid_bc, n_frag, n_bc, tss_flank_window, tss_window, tss_minimum_signal_window, tss_rolling_window, min_norm, check_for_duplicates, remove_duplicates, use_polars, **kwargs)
...
543 dtype=dtype,
544 copy=copy,
545 )

ValueError: Cannot convert float NaN to integer

Any help regarding this?

Thanks