diff --git a/CHANGELOG.md b/CHANGELOG.md
index 910320a44c..50e949a7a3 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -31,6 +31,7 @@ The format is based on [Keep a Changelog](http://keepachangelog.com/en/1.0.0/).
 - Switched Delivery Service active state to a three-value system, adding a state that will be used to prevent cache servers from deploying DS configuration.
 
 ### Fixed
+- [#4428](https://github.com/apache/trafficcontrol/issues/4428) *Traffic Ops* Fixed Internal Server Error with POST to `profileparameters` when POST body is empty
 - [#7179](https://github.com/apache/trafficcontrol/issues/7179) *Traffic Portal* Fixed search filter for Delivery Service Table
 - [#7174](https://github.com/apache/trafficcontrol/issues/7174) *Traffic Portal* Fixed topologies sort (table and Delivery Service's form)
 - [#5970](https://github.com/apache/trafficcontrol/issues/5970) *Traffic Portal* Fixed numeric sort in Delivery Service's form for DSCP
diff --git a/traffic_ops/testing/api/v3/profile_parameters_test.go b/traffic_ops/testing/api/v3/profile_parameters_test.go
index b2931a7cec..fe73aa262b 100644
--- a/traffic_ops/testing/api/v3/profile_parameters_test.go
+++ b/traffic_ops/testing/api/v3/profile_parameters_test.go
@@ -34,6 +34,8 @@ const queryParamFormat = "?profileId=%s&parameterId=%s"
 func TestProfileParameters(t *testing.T) {
 	WithObjs(t, []TCObj{CDNs, Types, Parameters, Profiles, ProfileParameters}, func() {
 
+		// This is a one off test to check POST with an empty JSON body
+		TestPostWithEmptyBody(t)
 		currentTime := time.Now().UTC().Add(-15 * time.Second)
 		tomorrow := currentTime.AddDate(0, 0, 1).Format(time.RFC1123)
 
@@ -163,6 +165,16 @@ func TestProfileParameters(t *testing.T) {
 	})
 }
 
+func TestPostWithEmptyBody(t *testing.T) {
+	resp, err := TOSession.Client.Post(TOSession.URL+"/api/3.0/profileparameters", "application/json", nil)
+	if err != nil {
+		t.Fatalf("error sending post to create profile parameter with an empty body: %v", err)
+	}
+	if resp.StatusCode != http.StatusBadRequest {
+		t.Errorf("expected to get a 400 error code, but received %d instead", resp.StatusCode)
+	}
+}
+
 func CreateTestProfileParameters(t *testing.T) {
 	for _, profile := range testData.Profiles {
 		profileID := GetProfileID(t, profile.Name)()
diff --git a/traffic_ops/testing/api/v4/profile_parameters_test.go b/traffic_ops/testing/api/v4/profile_parameters_test.go
index efa620533e..23365c12f0 100644
--- a/traffic_ops/testing/api/v4/profile_parameters_test.go
+++ b/traffic_ops/testing/api/v4/profile_parameters_test.go
@@ -33,6 +33,8 @@ import (
 func TestProfileParameters(t *testing.T) {
 	WithObjs(t, []TCObj{CDNs, Types, Parameters, Profiles, ProfileParameters}, func() {
 
+		// This is a one off test to check POST with an empty JSON body
+		TestPostWithEmptyBody(t)
 		currentTime := time.Now().UTC().Add(-15 * time.Second)
 		tomorrow := currentTime.AddDate(0, 0, 1).Format(time.RFC1123)
 
@@ -172,6 +174,16 @@ func TestProfileParameters(t *testing.T) {
 	})
 }
 
+func TestPostWithEmptyBody(t *testing.T) {
+	resp, err := TOSession.Client.Post(TOSession.URL+"/api/4.0/profileparameters", "application/json", nil)
+	if err != nil {
+		t.Fatalf("error sending post to create profile parameter with an empty body: %v", err)
+	}
+	if resp.StatusCode != http.StatusBadRequest {
+		t.Errorf("expected to get a 400 error code, but received %d instead", resp.StatusCode)
+	}
+}
+
 func TestProfileParameter(t *testing.T) {
 	WithObjs(t, []TCObj{CDNs, Types, Parameters, Profiles}, func() {
 
diff --git a/traffic_ops/testing/api/v5/profile_parameters_test.go b/traffic_ops/testing/api/v5/profile_parameters_test.go
index e44ebd7831..e2b264a231 100644
--- a/traffic_ops/testing/api/v5/profile_parameters_test.go
+++ b/traffic_ops/testing/api/v5/profile_parameters_test.go
@@ -33,6 +33,8 @@ import (
 func TestProfileParameters(t *testing.T) {
 	WithObjs(t, []TCObj{CDNs, Types, Parameters, Profiles, ProfileParameters}, func() {
 
+		// This is a one off test to check POST with an empty JSON body
+		TestPostWithEmptyBody(t)
 		currentTime := time.Now().UTC().Add(-15 * time.Second)
 		tomorrow := currentTime.AddDate(0, 0, 1).Format(time.RFC1123)
 
@@ -172,6 +174,16 @@ func TestProfileParameters(t *testing.T) {
 	})
 }
 
+func TestPostWithEmptyBody(t *testing.T) {
+	resp, err := TOSession.Client.Post(TOSession.URL+"/api/5.0/profileparameters", "application/json", nil)
+	if err != nil {
+		t.Fatalf("error sending post to create profile parameter with an empty body: %v", err)
+	}
+	if resp.StatusCode != http.StatusBadRequest {
+		t.Errorf("expected to get a 400 error code, but received %d instead", resp.StatusCode)
+	}
+}
+
 func TestProfileParameter(t *testing.T) {
 	WithObjs(t, []TCObj{CDNs, Types, Parameters, Profiles}, func() {
 
diff --git a/traffic_ops/traffic_ops_golang/api/shared_handlers.go b/traffic_ops/traffic_ops_golang/api/shared_handlers.go
index 3fe6e786d7..2f7e139801 100644
--- a/traffic_ops/traffic_ops_golang/api/shared_handlers.go
+++ b/traffic_ops/traffic_ops_golang/api/shared_handlers.go
@@ -495,6 +495,11 @@ func CreateHandler(creator Creator) http.HandlerFunc {
 				return
 			}
 
+			if len(data) == 0 {
+				HandleErr(w, r, inf.Tx.Tx, http.StatusBadRequest, errors.New("no request body supplied"), nil)
+				return
+			}
+
 			objSlice, err := parseMultipleCreates(data, objectType, inf)
 			if err != nil {
 				HandleErr(w, r, inf.Tx.Tx, http.StatusInternalServerError, nil, err)