From 7500ac7aa003a9056b8fb51f53f349602347cab8 Mon Sep 17 00:00:00 2001 From: Dan Gealow Date: Fri, 9 Aug 2024 12:02:05 -0400 Subject: [PATCH] Update CADD link and warn about licensing requirements (#42) --- examples/cadd/README.md | 9 ++++++--- 1 file changed, 6 insertions(+), 3 deletions(-) diff --git a/examples/cadd/README.md b/examples/cadd/README.md index 66fe9e0..aca059d 100644 --- a/examples/cadd/README.md +++ b/examples/cadd/README.md @@ -1,10 +1,13 @@ This directory contains scripts to convert [CADD](https://cadd.gs.washington.edu/download) to an `echtvar` archive. +**Note that a license is required for commercial use of CADD scores.** + Users can create their own archive like this: ``` -wget -c https://kircherlab.bihealth.org/download/CADD/v1.6/GRCh38/whole_genome_SNVs.tsv.gz -python cadd2vcf.py whole_genome_SNVs.tsv.gz | bcftools view -O b -o cadd.v1.6.bcf -echtvar encode cadd.v1.6.hg38.zip cadd.json cadd.v1.6.bcf +# See https://cadd.gs.washington.edu/download for links to older versions, hg19, and US mirrors +wget -c https://kircherlab.bihealth.org/download/CADD/v1.7/GRCh38/whole_genome_SNVs.tsv.gz +python cadd2vcf.py whole_genome_SNVs.tsv.gz | bcftools view -O b -o cadd.v1.7.bcf +echtvar encode cadd.v1.7.hg38.zip cadd.json cadd.v1.7.bcf ``` with these `cadd2vcf.py` from this directory and contents for `cadd.json`: