diff --git a/Formula/edirect.rb b/Formula/edirect.rb
index 7135b6bfa..554c08cca 100644
--- a/Formula/edirect.rb
+++ b/Formula/edirect.rb
@@ -1,9 +1,9 @@
 class Edirect < Formula
   desc "Access NCBI databases via the command-line"
   homepage "https://www.ncbi.nlm.nih.gov/books/NBK179288/"
-  url "https://ftp.ncbi.nlm.nih.gov/entrez/entrezdirect/versions/22.1.20240517/edirect.tar.gz"
-  version "22.1"
-  sha256 "28d9cc2d353323375a2102e9031e229943d1f1f975f140d0815db3e5a111f235"
+  url "https://ftp.ncbi.nlm.nih.gov/entrez/entrezdirect/versions/22.4.20240812/edirect-22.4.20240812.tar.gz"
+  version "22.4"
+  sha256 "3320e0b0859b85ecd21248323c792d671bfed8c9c60b1f414a3e0e3c648d8681"
 
   bottle do
     root_url "https://ghcr.io/v2/brewsci/bio"
@@ -13,51 +13,12 @@ class Edirect < Formula
   end
 
   depends_on "cpanminus" => :build
-  depends_on "openssl"
+  depends_on "go" => :build
+  depends_on "openssl@3"
 
   uses_from_macos "perl"
   uses_from_macos "zlib"
 
-  # macOS CIRCLE-CI often fails on https accesses. Use ftp accesses.
-  resource "xtract" do
-    if OS.mac? && Hardware::CPU.arm?
-      url "https://ftp.ncbi.nlm.nih.gov/entrez/entrezdirect/versions/22.1.20240517/xtract.Silicon.gz"
-      sha256 "7c841d4e2aeaf4e095ca721d2a6266422580c8fdfc5f9f33b5c55d3c8d9ca543"
-    elsif OS.mac?
-      url "https://ftp.ncbi.nlm.nih.gov/entrez/entrezdirect/versions/22.1.20240517/xtract.Darwin.gz"
-      sha256 "394d2af9fe4b5595907b7cce70dd2f2f0a92a6975bb8b1502a7cdeeecbb1cfa2"
-    else
-      url "https://ftp.ncbi.nlm.nih.gov/entrez/entrezdirect/versions/22.1.20240517/xtract.Linux.gz"
-      sha256 "1e97ecfda18e45311c14b1628a097443a0079013ab16da47548d4da696063152"
-    end
-  end
-
-  resource "rchive" do
-    if OS.mac? && Hardware::CPU.arm?
-      url "https://ftp.ncbi.nlm.nih.gov/entrez/entrezdirect/versions/22.1.20240517/rchive.Silicon.gz"
-      sha256 "b1035e3ebf0e123303ce58f98ec17395348a3e000844a01223b3734a157ac372"
-    elsif OS.mac?
-      url "https://ftp.ncbi.nlm.nih.gov/entrez/entrezdirect/versions/22.1.20240517/rchive.Darwin.gz"
-      sha256 "8fd39230d9c9dcd5c3d263201b04b065fbacf09e77e2e75000aaed38ce8f88f5"
-    else
-      url "https://ftp.ncbi.nlm.nih.gov/entrez/entrezdirect/versions/22.1.20240517/rchive.Linux.gz"
-      sha256 "4a0af7405d6fc1da52ec554f4906ad6004d9662316852dd0e5816b3c0f519d5b"
-    end
-  end
-
-  resource "transmute" do
-    if OS.mac? && Hardware::CPU.arm?
-      url "https://ftp.ncbi.nlm.nih.gov/entrez/entrezdirect/versions/22.1.20240517/transmute.Silicon.gz"
-      sha256 "031822fede0e89beed8f7041c973ce4af1232e377341697bb6a6501c2dbca779"
-    elsif OS.mac?
-      url "https://ftp.ncbi.nlm.nih.gov/entrez/entrezdirect/versions/22.1.20240517/transmute.Darwin.gz"
-      sha256 "3dd7724b97a69f12205cbe3b09358d57f3224aadf789251f50b60ed8f3c964df"
-    else
-      url "https://ftp.ncbi.nlm.nih.gov/entrez/entrezdirect/versions/22.1.20240517/transmute.Linux.gz"
-      sha256 "295e369d2ab42c62ea289e698513a468a456a67ea6360bb9d7474aa6e1f006c8"
-    end
-  end
-
   def install
     rm %w[Mozilla-CA.tar.gz]
     rm Dir["*.go"]
@@ -83,12 +44,17 @@ def install
       name = File.basename script
       (bin/name).write_env_script(script, PERL5LIB: ENV["PERL5LIB"])
     end
-    bin.install resource("xtract")
-    bin.install resource("rchive")
+
+    cd "#{libexec}/cmd" do
+      system "./build.sh", bin
+    end
+    cd "#{libexec}/extern" do
+      system "./build.sh", bin
+    end
   end
 
   test do
-    %w[efetch esearch einfo efilter epost elink].each do |exe|
+    %w[efetch esearch einfo efilter epost elink xtract transmute rchive].each do |exe|
       assert_match version.to_s, shell_output("#{bin}/#{exe} -version")
     end
     # CIRCLE-CI MacOS often fails on https accesses