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Currently, the handling of mutation records with the 5'Flank mutation type differs based on whether custom filtered mutations are specified. Here’s the observed behavior:
Default Filtered Mutations:
When using the default filtered mutations, the 5'Flank mutation is selected, and the protein change field is set to "Promoter" specifically for the TERT gene. This is achieved via a check against whiteListGenesForPromoterMutations (see MutationFilter.java#L150).
Custom Filtered Mutations:
When a custom mutation filter list is applied, the whiteListGenesForPromoterMutations check is skipped, resulting in different handling for 5'Flank mutations (see MutationFilter.java#L133).
This asymmetry in behavior seems unintended and could lead to inconsistent mutation handling depending on the filter setup.
The text was updated successfully, but these errors were encountered:
Currently, the handling of mutation records with the 5'Flank mutation type differs based on whether custom filtered mutations are specified. Here’s the observed behavior:
Default Filtered Mutations:
When using the default filtered mutations, the 5'Flank mutation is selected, and the protein change field is set to "Promoter" specifically for the TERT gene. This is achieved via a check against whiteListGenesForPromoterMutations (see MutationFilter.java#L150).
Custom Filtered Mutations:
When a custom mutation filter list is applied, the whiteListGenesForPromoterMutations check is skipped, resulting in different handling for 5'Flank mutations (see MutationFilter.java#L133).
This asymmetry in behavior seems unintended and could lead to inconsistent mutation handling depending on the filter setup.
The text was updated successfully, but these errors were encountered: