diff --git a/packages/components/src/components/button/_mixins.scss b/packages/components/src/components/button/_mixins.scss
index 020f645206cc..c97aea4c4cec 100644
--- a/packages/components/src/components/button/_mixins.scss
+++ b/packages/components/src/components/button/_mixins.scss
@@ -29,6 +29,8 @@
   outline: none;
   position: relative;
   max-width: rem(320px);
+  // Fix to remove added margins on buttons in safari (see #5155)
+  margin: 0;
 
   &:disabled,
   &.#{$prefix}--btn--disabled {
diff --git a/packages/components/src/globals/scss/_css--reset.scss b/packages/components/src/globals/scss/_css--reset.scss
index d2e91732e7d3..8d60fd07128d 100644
--- a/packages/components/src/globals/scss/_css--reset.scss
+++ b/packages/components/src/globals/scss/_css--reset.scss
@@ -190,6 +190,11 @@
       box-sizing: border-box;
     }
 
+    // Fix to remove added margins on buttons in safari (see #5155)
+    button {
+      margin: 0;
+    }
+
     @include carbon--type-reset;
     @include carbon--icons;
   }