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Bug: fusion_driver() returns multiple DomainRetained values #100

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kelseykeith opened this issue Apr 19, 2023 · 2 comments
Open

Bug: fusion_driver() returns multiple DomainRetained values #100

kelseykeith opened this issue Apr 19, 2023 · 2 comments
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@kelseykeith
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kelseykeith commented Apr 19, 2023

Provide the command used or report the bug here

For some kinases with multiple domains, fusion_driver() returns multiple values for DomanRetained for the same fusion at the same breakpoint, ex DomainRetainedGene1A has both "Yes" and "Partial". See table for examples and a complete list of the kinases.

fusions_dup_domain_retained_anno.csv

What version are you using?

0.90.0
0.92.0

Add error message her

N/A

Add Session info

Run sessionInfo() and post the output below

Run in OpenTargets Docker environment

@kelseykeith kelseykeith added the bug Something isn't working label Apr 19, 2023
@migbro
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migbro commented Apr 19, 2023

@sakshamphul @jharenza does the latest release of annoFuse fix this? We have a 0.92 docker now

@jharenza
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jharenza commented May 4, 2023

@sakshamphul @jharenza does the latest release of annoFuse fix this? We have a 0.92 docker now

Sorry, never saw this message - No, this is a separate issue which you found upon pedcbio load and which Kelsey had fixed within the OPC repo, but we need to dig whether this is due to kinases having multiple domains - in which case, we can implement her fix over here as well, but it wasn't entirely clear why this is happening, so need to investigate.

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