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Pseudogene Control #3

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daniel-wells opened this issue Jan 30, 2016 · 0 comments
Open

Pseudogene Control #3

daniel-wells opened this issue Jan 30, 2016 · 0 comments
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@daniel-wells
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Use pseudogenes to find 'sampling distribution' (?) / null hypothesis, these genes should have no selection and therefore dNdS mean = 1 + variation. Enabling comparison of real effect vs chance.

Problems:

  • Pseudogene sequences not available for GRC37?
  • Annotations in ICGC VCF are simply "exon_variant" for pseudogenes - rather than nonsynon or synon
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