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Gracefully handle input from multiple individuals in annotate #16

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dnil opened this issue Sep 27, 2023 · 0 comments
Open

Gracefully handle input from multiple individuals in annotate #16

dnil opened this issue Sep 27, 2023 · 0 comments

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@dnil
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dnil commented Sep 27, 2023

See e.g. nf-core/raredisease#429.

Several possibilities here:

  1. actually use sample from RG to choose which blocks to use - effectively picking one individual
  2. flag to select which sample to track
  3. invent CSQ-like INFO tag for samples or use sample GT level output to store info, and actually make calls for each individual
  4. make calls for each (affected) individual and annotate with smallest autozygous region subset only - useful for RD discovery, less so for e.g. corroborating deletions
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