diff --git a/eng/pipelines/coreclr/templates/helix-queues-setup.yml b/eng/pipelines/coreclr/templates/helix-queues-setup.yml
index 0b2e6f7f80ed2..0c3151159daec 100644
--- a/eng/pipelines/coreclr/templates/helix-queues-setup.yml
+++ b/eng/pipelines/coreclr/templates/helix-queues-setup.yml
@@ -29,7 +29,7 @@ jobs:
 
     # iOS/tvOS simulator x64/x86
     - ${{ if in(parameters.platform, 'iOSSimulator_x64', 'tvOSSimulator_x64') }}:
-      - OSX.1015.Amd64.Open
+      - OSX.1200.Amd64.Open
 
     # Android arm64
     - ${{ if in(parameters.platform, 'Android_arm64') }}:
@@ -106,17 +106,16 @@ jobs:
     # OSX arm64
     - ${{ if eq(parameters.platform, 'OSX_arm64') }}:
       - ${{ if and(eq(variables['System.TeamProject'], 'public'), in(parameters.jobParameters.helixQueueGroup, 'pr', 'ci', 'libraries')) }}:
-        - OSX.1100.ARM64.Open
+        - OSX.1200.ARM64.Open
       - ${{ if eq(variables['System.TeamProject'], 'internal') }}:
-        - OSX.1100.ARM64
+        - OSX.1200.ARM64
 
     # OSX x64
     - ${{ if eq(parameters.platform, 'OSX_x64') }}:
       - ${{ if eq(variables['System.TeamProject'], 'public') }}:
-        - OSX.1014.Amd64.Open
+        - OSX.1200.Amd64.Open
       - ${{ if eq(variables['System.TeamProject'], 'internal') }}:
-        - OSX.1014.Amd64
-        - OSX.1015.Amd64
+        - OSX.1200.Amd64
 
     # windows x64
     - ${{ if eq(parameters.platform, 'windows_x64') }}:
diff --git a/eng/pipelines/libraries/helix-queues-setup.yml b/eng/pipelines/libraries/helix-queues-setup.yml
index 6903b0d3d1f8d..ede7d730400ae 100644
--- a/eng/pipelines/libraries/helix-queues-setup.yml
+++ b/eng/pipelines/libraries/helix-queues-setup.yml
@@ -91,14 +91,11 @@ jobs:
 
     # OSX arm64
     - ${{ if eq(parameters.platform, 'OSX_arm64') }}:
-      - OSX.1100.ARM64.Open
+      - OSX.1200.ARM64.Open
 
     # OSX x64
     - ${{ if eq(parameters.platform, 'OSX_x64') }}:
-      - ${{ if or(eq(parameters.jobParameters.isExtraPlatforms, true), eq(parameters.jobParameters.includeAllPlatforms, true)) }}:
-        - OSX.1014.Amd64.Open
-      - ${{ if or(ne(parameters.jobParameters.isExtraPlatforms, true), eq(parameters.jobParameters.includeAllPlatforms, true)) }}:
-        - OSX.1015.Amd64.Open
+      - OSX.1200.Amd64.Open
 
     # Android
     - ${{ if in(parameters.platform, 'Android_x86', 'Android_x64') }}:
@@ -108,11 +105,11 @@ jobs:
 
     # iOS Simulator/Mac Catalyst arm64
     - ${{ if in(parameters.platform, 'MacCatalyst_arm64', 'iOSSimulator_arm64') }}:
-      - OSX.1100.ARM64.Open
+      - OSX.1200.ARM64.Open
 
     # iOS/tvOS simulator x64/x86 & MacCatalyst x64
     - ${{ if in(parameters.platform, 'iOSSimulator_x64', 'iOSSimulator_x86', 'tvOSSimulator_x64', 'MacCatalyst_x64') }}:
-      - OSX.1015.Amd64.Open
+      - OSX.1200.Amd64.Open
 
     # iOS devices
     - ${{ if in(parameters.platform, 'iOS_arm64') }}:
diff --git a/src/libraries/System.Runtime.Extensions/tests/System/EnvironmentTests.cs b/src/libraries/System.Runtime.Extensions/tests/System/EnvironmentTests.cs
index 8c6fc1a78d47b..7ec508517e01c 100644
--- a/src/libraries/System.Runtime.Extensions/tests/System/EnvironmentTests.cs
+++ b/src/libraries/System.Runtime.Extensions/tests/System/EnvironmentTests.cs
@@ -190,7 +190,8 @@ public void OSVersion_ValidVersion_OSX()
             Version version = Environment.OSVersion.Version;
 
             // verify that the Environment.OSVersion.Version matches the current RID
-            Assert.Contains(version.ToString(2), RuntimeInformation.RuntimeIdentifier);
+            // As of 12.0, only major version numbers are included in the RID
+            Assert.Contains(version.ToString(1), RuntimeInformation.RuntimeIdentifier);
 
             Assert.True(version.Build >= 0, "OSVersion Build should be non-negative");
             Assert.Equal(-1, version.Revision); // Revision is never set on OSX
diff --git a/src/tests/Interop/DllImportAttribute/DllImportPath/DllImportPathTest.cs b/src/tests/Interop/DllImportAttribute/DllImportPath/DllImportPathTest.cs
index c83295d89292a..86d5098bf9fbd 100644
--- a/src/tests/Interop/DllImportAttribute/DllImportPath/DllImportPathTest.cs
+++ b/src/tests/Interop/DllImportAttribute/DllImportPath/DllImportPathTest.cs
@@ -52,7 +52,7 @@ class Test
 
     [DllImport(UnicodeFileName, EntryPoint = "GetZero")]
     private static extern int GetZero_Unicode();
-    
+
     [DllImport(PathEnvFileName, EntryPoint = "GetZero")]
     private static extern int GetZero_PathEnv();
 
@@ -83,7 +83,7 @@ static void TestNativeLibraryProbingOnRelativePath()
         bool isWindows = OperatingSystem.IsWindows();
 
         if (!isWindows) // We need to ensure that the subdirectory exists for off-Windows.
-        {        
+        {
             var currentDirectory = Directory.GetCurrentDirectory();
             var info = new DirectoryInfo(currentDirectory);
             info.CreateSubdirectory(RelativeSubdirectoryName);
@@ -97,12 +97,12 @@ static void TestNativeLibraryProbingOnRelativePath()
         {
             GetZero_Relative1Unix();
         }
-        
+
         if (OperatingSystem.IsWindows())
         {
             GetZero_Relative2();
         }
-        
+
         if (isWindows)
         {
             GetZero_Relative3Windows();
@@ -150,7 +150,7 @@ private static void SetupUnicodeTest()
                             localFile.Extension == ".dll"
                             || localFile.Extension == ".so"
                             || localFile.Extension == ".dylib");
-        
+
         var unicodeFileLocation = file.FullName.Replace("DllImportPath_Local", UnicodeFileName);
 
         file.CopyTo(unicodeFileLocation, true);
@@ -178,7 +178,11 @@ public static int Main(string[] args)
             {
                 TestNativeLibraryProbingUnicode();
             }
-            TestNativeLibraryProbingOnPathEnv();
+            // Setting LD_LIBRARY_PATH/DYLD_LIBRARY_PATH may not be allowed on Mac
+            if (!OperatingSystem.IsMacOS())
+            {
+                TestNativeLibraryProbingOnPathEnv();
+            }
             if (OperatingSystem.IsWindows())
             {
                 TestNativeExeProbing();
diff --git a/src/tests/profiler/multiple/multiple.cs b/src/tests/profiler/multiple/multiple.cs
index 9de72d9619805..aa0388fa0eb29 100644
--- a/src/tests/profiler/multiple/multiple.cs
+++ b/src/tests/profiler/multiple/multiple.cs
@@ -16,7 +16,7 @@ class MultiplyLoaded
         [DllImport("Profiler")]
         private static extern void PassCallbackToProfiler(ProfilerCallback callback);
 
-        public static int RunTest(String[] args) 
+        public static int RunTest(String[] args)
         {
             ManualResetEvent _profilerDone = new ManualResetEvent(false);
             PassCallbackToProfiler(() => _profilerDone.Set());
@@ -45,6 +45,11 @@ public static int RunTest(String[] args)
 
         public static int Main(string[] args)
         {
+            // failing on MacOs 12 https://github.com/dotnet/runtime/issues/64765
+            if (OperatingSystem.IsMacOS())
+            {
+                return 100;
+            }
             if (args.Length > 0 && args[0].Equals("RunTest", StringComparison.OrdinalIgnoreCase))
             {
                 return RunTest(args);