diff --git a/src/coreclr/jit/codegencommon.cpp b/src/coreclr/jit/codegencommon.cpp
index a33b4b94a5994..8585bab6bc0bd 100644
--- a/src/coreclr/jit/codegencommon.cpp
+++ b/src/coreclr/jit/codegencommon.cpp
@@ -12461,6 +12461,17 @@ void CodeGen::genPoisonFrame(regMaskTP regLiveIn)
 
         assert(varDsc->lvOnFrame);
 
+        int size = (int)compiler->lvaLclSize(varNum);
+
+        if (size / TARGET_POINTER_SIZE > 16)
+        {
+            // For very large structs the offsets in the movs we emit below can
+            // grow too large to be handled properly by JIT. Furthermore, while
+            // this is only debug code, for very large structs this can bloat
+            // the code too much due to the singular movs used.
+            continue;
+        }
+
         if (!hasPoisonImm)
         {
 #ifdef TARGET_64BIT
@@ -12478,8 +12489,7 @@ void CodeGen::genPoisonFrame(regMaskTP regLiveIn)
 #else
         int addr = 0;
 #endif
-        int size = (int)compiler->lvaLclSize(varNum);
-        int end  = addr + size;
+        int end = addr + size;
         for (int offs = addr; offs < end;)
         {
 #ifdef TARGET_64BIT