diff --git a/eng/pipelines/runtime-sanitized.yml b/eng/pipelines/runtime-sanitized.yml
index 5db421762ed0d..ed0334b61b3e9 100644
--- a/eng/pipelines/runtime-sanitized.yml
+++ b/eng/pipelines/runtime-sanitized.yml
@@ -30,6 +30,7 @@ extends:
           platforms:
             - linux_x64
             - osx_x64
+            - windows_x64
           variables:
             - name: _nativeSanitizersArg
               value: -fsanitize address
@@ -81,6 +82,38 @@ extends:
                   scenarios:
                     - normal
 
+      #
+      # Build the whole product with CoreCLR and run libraries tests with AddressSanitizer
+      #
+      - template: /eng/pipelines/common/platform-matrix.yml
+        parameters:
+          jobTemplate: /eng/pipelines/common/global-build-job.yml
+          buildConfig: Debug
+          runtimeFlavor: coreclr
+          platforms:
+            - windows_x64
+          variables:
+            - name: _nativeSanitizersArg
+              value: -fsanitize address
+          jobParameters:
+            testGroup: innerloop
+            nameSuffix: CoreCLR_LibrariesTests
+            buildArgs: -s clr+libs+libs.tests -c $(_BuildConfig) -rc Checked $(_nativeSanitizersArg) /p:ArchiveTests=true
+            timeoutInMinutes: 360
+            # Hard-code queues here as we don't want to run on pre Win-10 queues
+            # and we don't want to overcompilcate helix-queues-setup.yml just for this case.
+            helixQueues:
+              - Windows.Amd64.Server2022.Open
+              - Windows.11.Amd64.Client.Open
+            # extra steps, run tests
+            postBuildSteps:
+              - template: /eng/pipelines/libraries/helix.yml
+                parameters:
+                  creator: dotnet-bot
+                  testRunNamePrefixSuffix: Libraries_$(_BuildConfig)
+                  scenarios:
+                    - normal
+
       #
       # NativeAOT release build and smoke tests with AddressSanitizer
       #
@@ -92,6 +125,7 @@ extends:
           platforms:
             - linux_x64
             - osx_x64
+            - windows_x64
           variables:
             - name: _nativeSanitizersArg
               value: -fsanitize address
diff --git a/eng/testing/linker/project.csproj.template b/eng/testing/linker/project.csproj.template
index f4177ee854261..41466e8d4492a 100644
--- a/eng/testing/linker/project.csproj.template
+++ b/eng/testing/linker/project.csproj.template
@@ -98,4 +98,8 @@
 
   <Import Project="{NativeSanitizersTargets}" />
 
+  <ItemGroup>
+    <Content Include="@(SanitizerRuntimeToCopy->'{SanitizerRuntimeFolder}/%(Identity)')" CopyToOutputDirectory="PreserveNewest" />
+  </ItemGroup>
+
 </Project>
diff --git a/eng/testing/linker/trimmingTests.targets b/eng/testing/linker/trimmingTests.targets
index a13c1a1250442..926bafa52cfef 100644
--- a/eng/testing/linker/trimmingTests.targets
+++ b/eng/testing/linker/trimmingTests.targets
@@ -119,7 +119,8 @@
                                                  .Replace('{MicrosoftNetCoreAppRuntimePackDir}', '$(MicrosoftNetCoreAppRuntimePackDir)')
                                                  .Replace('{NativeSanitizersTargets}', '$(RepositoryEngineeringDir)nativeSanitizers.targets')
                                                  .Replace('{AppHostSourcePath}', '$(AppHostSourcePath)')
-                                                 .Replace('{SingleFileHostSourcePath}', '$(SingleFileHostSourcePath)'))"
+                                                 .Replace('{SingleFileHostSourcePath}', '$(SingleFileHostSourcePath)')
+                                                 .Replace('{SanitizerRuntimeFolder}', '$(DotNetHostBinDir)'))"
                       Overwrite="true" />
     <Copy SourceFiles="$(_projectSourceFile);
                        @(_additionalProjectSourceFiles)"
diff --git a/src/coreclr/pgosupport.cmake b/src/coreclr/pgosupport.cmake
index 34a42781ab2c8..fe42dc8e57f36 100644
--- a/src/coreclr/pgosupport.cmake
+++ b/src/coreclr/pgosupport.cmake
@@ -38,7 +38,7 @@ function(add_pgo TargetName)
                 endif()
             endif(UPPERCASE_CMAKE_BUILD_TYPE STREQUAL RELEASE OR UPPERCASE_CMAKE_BUILD_TYPE STREQUAL RELWITHDEBINFO)
         endif(CLR_CMAKE_HOST_WIN32)
-    elseif(CLR_CMAKE_PGO_OPTIMIZE)
+    elseif(CLR_CMAKE_PGO_OPTIMIZE AND NOT CLR_CMAKE_ENABLE_SANITIZERS)
         if(CLR_CMAKE_HOST_WIN32)
             set(ProfileFileName "${TargetName}.pgd")
         else(CLR_CMAKE_HOST_WIN32)
diff --git a/src/tests/readytorun/tests/mainv1.csproj b/src/tests/readytorun/tests/mainv1.csproj
index 1b80a5c999de5..dba79aa2d2b35 100644
--- a/src/tests/readytorun/tests/mainv1.csproj
+++ b/src/tests/readytorun/tests/mainv1.csproj
@@ -5,6 +5,8 @@
     <CrossGenTest>false</CrossGenTest>
     <!-- https://github.com/dotnet/runtime/issues/73138 -->
     <IlasmRoundTripIncompatible>true</IlasmRoundTripIncompatible>
+    <!-- This test launches crossgen2 with dotnet, so we would need a non-sanitzed jitinterface library. To simplify our infrastructure, we'll instead skip this test. -->
+    <CLRTestTargetUnsupported Condition="'$(EnableNativeSanitizers)' != ''">true</CLRTestTargetUnsupported>
   </PropertyGroup>
   <ItemGroup>
     <ProjectReference Include="fieldgetter.ilproj" />
@@ -156,7 +158,7 @@ export DOTNET_GCName DOTNET_GCStress DOTNET_HeapVerify DOTNET_ReadyToRun
 ]]></CLRTestBashPreCommands>
   </PropertyGroup>
 
-  <Target Name="CopyTestAssemblyToOutputs" AfterTargets="Build">
+  <Target Name="CopyTestAssemblyToOutputs" AfterTargets="Build" Condition="'$(CLRTestTargetUnsupported)' != 'true'">
     <PropertyGroup>
       <TestAssemblyName>test.dll</TestAssemblyName>
       <TestAssemblySourcePath>$(OutputPath)/../testv1/test/</TestAssemblySourcePath>
diff --git a/src/tests/readytorun/tests/mainv2.csproj b/src/tests/readytorun/tests/mainv2.csproj
index 9ff6350fef141..72e5d816629f0 100644
--- a/src/tests/readytorun/tests/mainv2.csproj
+++ b/src/tests/readytorun/tests/mainv2.csproj
@@ -5,6 +5,8 @@
     <CrossGenTest>false</CrossGenTest>
     <!-- https://github.com/dotnet/runtime/issues/73954 -->
     <IlasmRoundTripIncompatible>true</IlasmRoundTripIncompatible>
+    <!-- This test launches crossgen2 with dotnet, so we would need a non-sanitzed jitinterface library. To simplify our infrastructure, we'll instead skip this test. -->
+    <CLRTestTargetUnsupported Condition="'$(EnableNativeSanitizers)' != ''">true</CLRTestTargetUnsupported>
   </PropertyGroup>
   <ItemGroup>
     <ProjectReference Include="fieldgetter.ilproj" />
@@ -158,7 +160,7 @@ export DOTNET_GCName DOTNET_GCStress DOTNET_HeapVerify DOTNET_ReadyToRun
 ]]></CLRTestBashPreCommands>
   </PropertyGroup>
 
-  <Target Name="CopyTestAssemblyToOutputs" AfterTargets="Build">
+  <Target Name="CopyTestAssemblyToOutputs" AfterTargets="Build" Condition="'$(CLRTestTargetUnsupported)' != 'true'">
     <PropertyGroup>
       <TestAssemblyName>test.dll</TestAssemblyName>
       <TestV1AssemblySourcePath>$(OutputPath)/../testv1/test/</TestV1AssemblySourcePath>