diff --git a/x-pack/scripts/functional_tests.js b/x-pack/scripts/functional_tests.js
index 2ac8fff6ef8ab7..7b2c2c2b7840f1 100644
--- a/x-pack/scripts/functional_tests.js
+++ b/x-pack/scripts/functional_tests.js
@@ -13,7 +13,11 @@ require('@kbn/test').runTestsCli([
   require.resolve('../test/api_integration/config_security_basic.js'),
   require.resolve('../test/api_integration/config.js'),
   require.resolve('../test/alerting_api_integration/spaces_only/config.ts'),
-  require.resolve('../test/alerting_api_integration/security_and_spaces/config.ts'),
+  // FLAKY: https://github.com/elastic/kibana/issues/50079
+  // FLAKY: https://github.com/elastic/kibana/issues/50074
+  // FLAKY: https://github.com/elastic/kibana/issues/48709
+  // FLAKY: https://github.com/elastic/kibana/issues/50078
+  // require.resolve('../test/alerting_api_integration/security_and_spaces/config.ts'),
   require.resolve('../test/plugin_api_integration/config.js'),
   require.resolve('../test/kerberos_api_integration/config'),
   require.resolve('../test/kerberos_api_integration/anonymous_access.config'),
diff --git a/x-pack/test/alerting_api_integration/security_and_spaces/tests/index.ts b/x-pack/test/alerting_api_integration/security_and_spaces/tests/index.ts
index a643bd8f9f64fc..af9804473a4489 100644
--- a/x-pack/test/alerting_api_integration/security_and_spaces/tests/index.ts
+++ b/x-pack/test/alerting_api_integration/security_and_spaces/tests/index.ts
@@ -18,7 +18,11 @@ export default function alertingApiIntegrationTests({
   const spacesService: SpacesService = getService('spaces');
   const esArchiver = getService('esArchiver');
 
-  describe('alerting api integration security and spaces enabled', function() {
+  // FLAKY: https://github.com/elastic/kibana/issues/50079
+  // FLAKY: https://github.com/elastic/kibana/issues/50074
+  // FLAKY: https://github.com/elastic/kibana/issues/48709
+  // FLAKY: https://github.com/elastic/kibana/issues/50078
+  describe.skip('alerting api integration security and spaces enabled', function() {
     this.tags('ciGroup1');
 
     before(async () => {