diff --git a/Libraries/ActionSheetIOS/ActionSheetIOS.js b/Libraries/ActionSheetIOS/ActionSheetIOS.js
index 076ab004a56eb3..9852791cdf67a7 100644
--- a/Libraries/ActionSheetIOS/ActionSheetIOS.js
+++ b/Libraries/ActionSheetIOS/ActionSheetIOS.js
@@ -33,6 +33,7 @@ const ActionSheetIOS = {
    * - `destructiveButtonIndex` (int or array of ints) - index or indices of destructive buttons in `options`
    * - `title` (string) - a title to show above the action sheet
    * - `message` (string) - a message to show below the title
+   * - `disabledButtonIndices` (array of numbers) - a list of button indices which should be disabled
    *
    * The 'callback' function takes one parameter, the zero-based index
    * of the selected item.
@@ -49,6 +50,7 @@ const ActionSheetIOS = {
       +anchor?: ?number,
       +tintColor?: ColorValue | ProcessedColorValue,
       +userInterfaceStyle?: string,
+      +disabledButtonIndices?: Array<number>,
     |},
     callback: (buttonIndex: number) => void,
   ) {
diff --git a/Libraries/ActionSheetIOS/NativeActionSheetManager.js b/Libraries/ActionSheetIOS/NativeActionSheetManager.js
index 063d9147e1d69b..6d86200d9accd6 100644
--- a/Libraries/ActionSheetIOS/NativeActionSheetManager.js
+++ b/Libraries/ActionSheetIOS/NativeActionSheetManager.js
@@ -25,6 +25,7 @@ export interface Spec extends TurboModule {
       +anchor?: ?number,
       +tintColor?: ?number,
       +userInterfaceStyle?: ?string,
+      +disabledButtonIndices?: Array<number>,
     |},
     callback: (buttonIndex: number) => void,
   ) => void;
diff --git a/Libraries/FBReactNativeSpec/FBReactNativeSpec/FBReactNativeSpec.h b/Libraries/FBReactNativeSpec/FBReactNativeSpec/FBReactNativeSpec.h
index 4323cd25040c21..56a2c6b9c16371 100644
--- a/Libraries/FBReactNativeSpec/FBReactNativeSpec/FBReactNativeSpec.h
+++ b/Libraries/FBReactNativeSpec/FBReactNativeSpec/FBReactNativeSpec.h
@@ -114,6 +114,7 @@ namespace JS {
       NSString *message() const;
       folly::Optional<facebook::react::LazyVector<NSString *>> options() const;
       folly::Optional<facebook::react::LazyVector<double>> destructiveButtonIndices() const;
+      folly::Optional<facebook::react::LazyVector<double>> disabledButtonIndices() const;
       folly::Optional<double> cancelButtonIndex() const;
       folly::Optional<double> anchor() const;
       folly::Optional<double> tintColor() const;
@@ -2922,6 +2923,11 @@ inline folly::Optional<facebook::react::LazyVector<double>> JS::NativeActionShee
   id const p = _v[@"destructiveButtonIndices"];
   return RCTBridgingToOptionalVec(p, ^double(id itemValue_0) { return RCTBridgingToDouble(itemValue_0); });
 }
+inline folly::Optional<facebook::react::LazyVector<double>> JS::NativeActionSheetManager::SpecShowActionSheetWithOptionsOptions::disabledButtonIndices() const
+{
+  id const p = _v[@"disabledButtonIndices"];
+  return RCTBridgingToOptionalVec(p, ^double(id itemValue_0) { return RCTBridgingToDouble(itemValue_0); });
+}
 inline folly::Optional<double> JS::NativeActionSheetManager::SpecShowActionSheetWithOptionsOptions::cancelButtonIndex() const
 {
   id const p = _v[@"cancelButtonIndex"];
diff --git a/RNTester/js/examples/ActionSheetIOS/ActionSheetIOSExample.js b/RNTester/js/examples/ActionSheetIOS/ActionSheetIOSExample.js
index c1130357829df5..a5ea2d79771d82 100644
--- a/RNTester/js/examples/ActionSheetIOS/ActionSheetIOSExample.js
+++ b/RNTester/js/examples/ActionSheetIOS/ActionSheetIOSExample.js
@@ -25,6 +25,7 @@ const ScreenshotManager = NativeModules.ScreenshotManager;
 const BUTTONS = ['Option 0', 'Option 1', 'Option 2', 'Delete', 'Cancel'];
 const DESTRUCTIVE_INDEX = 3;
 const CANCEL_INDEX = 4;
+const DISABLED_BUTTON_INDICES = [1, 2];
 
 type Props = $ReadOnly<{||}>;
 type State = {|clicked: string|};
@@ -138,6 +139,37 @@ class ActionSheetAnchorExample extends React.Component<
   };
 }
 
+class ActionSheetDisabledExample extends React.Component<Props, State> {
+  state = {
+    clicked: 'none',
+  };
+
+  render() {
+    return (
+      <View>
+        <Text onPress={this.showActionSheet} style={style.button}>
+          Click to show the ActionSheet
+        </Text>
+        <Text>Clicked button: {this.state.clicked}</Text>
+      </View>
+    );
+  }
+
+  showActionSheet = () => {
+    ActionSheetIOS.showActionSheetWithOptions(
+      {
+        options: BUTTONS,
+        cancelButtonIndex: CANCEL_INDEX,
+        destructiveButtonIndex: DESTRUCTIVE_INDEX,
+        disabledButtonIndices: DISABLED_BUTTON_INDICES,
+      },
+      buttonIndex => {
+        this.setState({clicked: BUTTONS[buttonIndex]});
+      },
+    );
+  };
+}
+
 class ShareActionSheetExample extends React.Component<
   $FlowFixMeProps,
   $FlowFixMeState,
@@ -315,6 +347,12 @@ exports.examples = [
       return <ActionSheetAnchorExample />;
     },
   },
+  {
+    title: 'Show Action Sheet with disabled buttons',
+    render(): React.Element<any> {
+      return <ActionSheetDisabledExample />;
+    },
+  },
   {
     title: 'Show Share Action Sheet',
     render(): React.Element<any> {
diff --git a/React/CoreModules/RCTActionSheetManager.mm b/React/CoreModules/RCTActionSheetManager.mm
index 754e461157349d..62e38b29e1b13b 100644
--- a/React/CoreModules/RCTActionSheetManager.mm
+++ b/React/CoreModules/RCTActionSheetManager.mm
@@ -76,6 +76,9 @@ - (void)presentViewController:(UIViewController *)alertController
   NSInteger cancelButtonIndex =
       options.cancelButtonIndex() ? [RCTConvert NSInteger:@(*options.cancelButtonIndex())] : -1;
   NSArray<NSNumber *> *destructiveButtonIndices;
+  NSArray<NSNumber *> *disabledButtonIndices = RCTConvertVecToArray(*options.disabledButtonIndices(), ^id(double element) {
+      return @(element);
+  });
   if (options.destructiveButtonIndices()) {
     destructiveButtonIndices = RCTConvertVecToArray(*options.destructiveButtonIndices(), ^id(double element) {
       return @(element);
@@ -98,6 +101,7 @@ - (void)presentViewController:(UIViewController *)alertController
       @"destructiveButtonIndices" : destructiveButtonIndices,
       @"anchor" : anchor,
       @"tintColor" : tintColor,
+      @"disabledButtonIndices" : disabledButtonIndices,
     });
     return;
   }
@@ -132,6 +136,15 @@ - (void)presentViewController:(UIViewController *)alertController
     index++;
   }
 
+  for (NSNumber *disabledButtonIndex in disabledButtonIndices) {
+    if ([disabledButtonIndex integerValue] < buttons.count) {
+      [alertController.actions[[disabledButtonIndex integerValue]] setEnabled:false];
+    } else {
+      RCTLogError(@"Index %@ from `disabledButtonIndices` is out of bounds. Maximum index value is %@.", @([disabledButtonIndex integerValue]), @(buttons.count - 1));
+      return;
+    }
+  }
+
   alertController.view.tintColor = tintColor;
 #if defined(__IPHONE_OS_VERSION_MAX_ALLOWED) && defined(__IPHONE_13_0) && \
     __IPHONE_OS_VERSION_MAX_ALLOWED >= __IPHONE_13_0