diff --git a/setup.py b/setup.py
index e5a926e80a11..9937aabb97c6 100644
--- a/setup.py
+++ b/setup.py
@@ -52,7 +52,6 @@
 REQUIREMENTS = [
     'google-cloud-bigquery >= 0.22.1, < 0.23dev',
     'google-cloud-bigtable >= 0.22.0, < 0.23dev',
-    'google-cloud-happybase >= 0.22.0, < 0.23dev',
     'google-cloud-core >= 0.22.1, < 0.23dev',
     'google-cloud-datastore >= 0.22.0, < 0.23dev',
     'google-cloud-dns >= 0.22.0, < 0.23dev',