diff --git a/setup.py b/setup.py
index 0d613f6d..decd0964 100644
--- a/setup.py
+++ b/setup.py
@@ -30,8 +30,8 @@
 release_status = "Development Status :: 5 - Production/Stable"
 dependencies = [
     "google-api-core[grpc] >= 1.32.0, <3.0.0dev,!=2.0.*,!=2.1.*,!=2.2.*,!=2.3.*,!=2.4.*,!=2.5.*,!=2.6.*,!=2.7.*",
-    "proto-plus >= 1.15.0, <2.0.0dev",
-    "protobuf >= 3.19.0, <4.0.0dev",
+    "proto-plus >= 1.22.0, <2.0.0dev",
+    "protobuf >= 3.19.0, <5.0.0dev",
 ]
 extras = {"pandas": "pandas >= 0.17.1"}
 
diff --git a/testing/constraints-3.7.txt b/testing/constraints-3.7.txt
index 005a661a..44aaf506 100644
--- a/testing/constraints-3.7.txt
+++ b/testing/constraints-3.7.txt
@@ -5,6 +5,6 @@
 # e.g., if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0dev",
 # Then this file should have google-cloud-foo==1.14.0
 google-api-core==1.32.0
-proto-plus==1.15.0
+proto-plus==1.22.0
 pandas==0.23.2
 protobuf==3.19.0