diff --git a/lib/hexo/post.ts b/lib/hexo/post.ts
index 0d6810a50e..790a540663 100644
--- a/lib/hexo/post.ts
+++ b/lib/hexo/post.ts
@@ -69,7 +69,7 @@ class PostRenderEscape {
    * @returns string
    */
   escapeAllSwigTags(str: string) {
-    if (!/(\{\{.+?\}\})|(\{#.+?#\})|(\{%.+?%\})/.test(str)) {
+    if (!/(\{\{.+?\}\})|(\{#.+?#\})|(\{%.+?%\})/s.test(str)) {
       return str;
     }
     let state = STATE_PLAINTEXT;
diff --git a/test/scripts/hexo/post.js b/test/scripts/hexo/post.js
index cf7dd423b2..109bf2367b 100644
--- a/test/scripts/hexo/post.js
+++ b/test/scripts/hexo/post.js
@@ -1396,4 +1396,22 @@ describe('Post', () => {
       should.fail();
     } catch (err) {}
   });
+
+  // https://github.com/hexojs/hexo/issues/5401
+  it('render() - tags in different lines', async () => {
+    const content = [
+      '{% link',
+      'foobar',
+      'https://hexo.io/',
+      'tttitle',
+      '%}'
+    ].join('\n');
+
+    const data = await post.render(null, {
+      content,
+      engine: 'markdown'
+    });
+
+    data.content.should.eql('<a href="https://hexo.io/" title="tttitle" target="">foobar</a>');
+  });
 });