diff --git a/src/babelPluginTsdx.ts b/src/babelPluginTsdx.ts
index def0f46a7..9458d2d90 100644
--- a/src/babelPluginTsdx.ts
+++ b/src/babelPluginTsdx.ts
@@ -78,7 +78,6 @@ export const babelPluginTsdx = babelPlugin.custom(() => ({
           name: 'babel-plugin-polyfill-regenerator',
           // don't pollute global env as this is being used in a library
           method: 'usage-pure',
-          targets: customOptions.targets,
         },
         {
           name: '@babel/plugin-proposal-class-properties',
diff --git a/test/e2e/tsdx-build-default.test.ts b/test/e2e/tsdx-build-default.test.ts
index b63adb8fd..f2d4c6618 100644
--- a/test/e2e/tsdx-build-default.test.ts
+++ b/test/e2e/tsdx-build-default.test.ts
@@ -59,6 +59,14 @@ describe('tsdx build :: zero-config defaults', () => {
     expect(matched).toBeTruthy();
   });
 
+  it('should not bundle regeneratorRuntime when targeting Node', () => {
+    const output = execWithCache('node ../dist/index.js build --target node');
+    expect(output.code).toBe(0);
+
+    const matched = grep(/regeneratorRuntime = r/, ['dist/build-default.*.js']);
+    expect(matched).toBeFalsy();
+  });
+
   it('should clean the dist directory before rebuilding', () => {
     let output = execWithCache('node ../dist/index.js build');
     expect(output.code).toBe(0);