diff --git a/CHANGELOG.md b/CHANGELOG.md
index ca627f1d0cbe..67253e1f4e18 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -61,6 +61,9 @@
 
 ### Fixes
 
+* `[jest-runtime]` Throw a more useful error when trying to require modules
+  after the test environment is torn down
+  ([#5888](https://github.com/facebook/jest/pull/5888))
 * `[jest-mock]` [**BREAKING**] Replace timestamps with `invocationCallOrder`
   ([#5867](https://github.com/facebook/jest/pull/5867))
 * `[jest-jasmine2]` Install `sourcemap-support` into normal runtime to catch
@@ -71,8 +74,6 @@
   mode. ([#5861](https://github.com/facebook/jest/pull/5861))
 * `[jest-mock]` Extend .toHaveBeenCalled return message with outcome
   ([#5951](https://github.com/facebook/jest/pull/5951))
-* `[jest-message-util]` Include column in stack frames
-  ([#5889](https://github.com/facebook/jest/pull/5889))
 * `[jest-runner]` Assign `process.env.JEST_WORKER_ID="1"` when in runInBand mode
   ([#5860](https://github.com/facebook/jest/pull/5860))
 * `[jest-cli]` Add descriptive error message when trying to use
diff --git a/integration-tests/__tests__/__snapshots__/require_after_teardown.test.js.snap b/integration-tests/__tests__/__snapshots__/require_after_teardown.test.js.snap
new file mode 100644
index 000000000000..e200d37782aa
--- /dev/null
+++ b/integration-tests/__tests__/__snapshots__/require_after_teardown.test.js.snap
@@ -0,0 +1,12 @@
+// Jest Snapshot v1, https://goo.gl/fbAQLP
+
+exports[`prints useful error for requires after test is done 1`] = `
+"ReferenceError: You are trying to \`import\` a file after the Jest environment has been torn down.
+
+       9 | test('require after done', () => {
+      10 |   setTimeout(() => {
+    > 11 |     const double = require('../');
+      12 | 
+      13 |     expect(double(5)).toBe(10);
+      14 |   }, 0);"
+`;
diff --git a/integration-tests/__tests__/require_after_teardown.test.js b/integration-tests/__tests__/require_after_teardown.test.js
new file mode 100644
index 000000000000..1a13b9ac5d38
--- /dev/null
+++ b/integration-tests/__tests__/require_after_teardown.test.js
@@ -0,0 +1,26 @@
+/**
+ * Copyright (c) 2014-present, Facebook, Inc. All rights reserved.
+ *
+ * This source code is licensed under the MIT license found in the
+ * LICENSE file in the root directory of this source tree.
+ *
+ * @flow
+ */
+
+'use strict';
+
+const runJest = require('../runJest');
+
+test('prints useful error for requires after test is done', () => {
+  const {stderr} = runJest('require-after-teardown');
+
+  const interestingLines = stderr
+    .split('\n')
+    .slice(9, 17)
+    .join('\n');
+
+  expect(interestingLines).toMatchSnapshot();
+  expect(stderr.split('\n')[18]).toMatch(
+    new RegExp('(__tests__/late-require.test.js:11:20)'),
+  );
+});
diff --git a/integration-tests/require-after-teardown/__tests__/late-require.test.js b/integration-tests/require-after-teardown/__tests__/late-require.test.js
new file mode 100644
index 000000000000..116a9ddde81e
--- /dev/null
+++ b/integration-tests/require-after-teardown/__tests__/late-require.test.js
@@ -0,0 +1,15 @@
+/**
+ * Copyright (c) 2014-present, Facebook, Inc. All rights reserved.
+ *
+ * This source code is licensed under the MIT license found in the
+ * LICENSE file in the root directory of this source tree.
+ */
+'use strict';
+
+test('require after done', () => {
+  setTimeout(() => {
+    const double = require('../');
+
+    expect(double(5)).toBe(10);
+  }, 0);
+});
diff --git a/integration-tests/require-after-teardown/index.js b/integration-tests/require-after-teardown/index.js
new file mode 100644
index 000000000000..39261f1e45e9
--- /dev/null
+++ b/integration-tests/require-after-teardown/index.js
@@ -0,0 +1,10 @@
+/**
+ * Copyright (c) 2014-present, Facebook, Inc. All rights reserved.
+ *
+ * This source code is licensed under the MIT license found in the
+ * LICENSE file in the root directory of this source tree.
+ */
+
+module.exports = function double(input) {
+  return input * 2;
+};
diff --git a/integration-tests/require-after-teardown/package.json b/integration-tests/require-after-teardown/package.json
new file mode 100644
index 000000000000..148788b25446
--- /dev/null
+++ b/integration-tests/require-after-teardown/package.json
@@ -0,0 +1,5 @@
+{
+  "jest": {
+    "testEnvironment": "node"
+  }
+}
diff --git a/packages/jest-runtime/package.json b/packages/jest-runtime/package.json
index c4cb00c48713..0469662a3163 100644
--- a/packages/jest-runtime/package.json
+++ b/packages/jest-runtime/package.json
@@ -16,6 +16,7 @@
     "graceful-fs": "^4.1.11",
     "jest-config": "^22.4.2",
     "jest-haste-map": "^22.4.2",
+    "jest-message-util": "^22.4.0",
     "jest-regex-util": "^22.1.0",
     "jest-resolve": "^22.4.2",
     "jest-snapshot": "^22.4.0",
diff --git a/packages/jest-runtime/src/index.js b/packages/jest-runtime/src/index.js
index d179cdfbb81b..b21208815648 100644
--- a/packages/jest-runtime/src/index.js
+++ b/packages/jest-runtime/src/index.js
@@ -19,6 +19,7 @@ import type {SourceMapRegistry} from 'types/SourceMaps';
 
 import path from 'path';
 import HasteMap from 'jest-haste-map';
+import {formatStackTrace, separateMessageFromStack} from 'jest-message-util';
 import Resolver from 'jest-resolve';
 import {createDirectory, deepCyclicCopy} from 'jest-util';
 import {escapePathForRegex} from 'jest-regex-util';
@@ -551,9 +552,28 @@ class Runtime {
       }
     }
 
-    const wrapper = this._environment.runScript(transformedFile.script)[
-      ScriptTransformer.EVAL_RESULT_VARIABLE
-    ];
+    const runScript = this._environment.runScript(transformedFile.script);
+
+    if (runScript === null) {
+      const originalStack = new ReferenceError(
+        'You are trying to `import` a file after the Jest environment has been torn down.',
+      ).stack
+        .split('\n')
+        // Remove this file from the stack (jest-message-utils will keep one line)
+        .filter(line => line.indexOf(__filename) === -1)
+        .join('\n');
+
+      const {message, stack} = separateMessageFromStack(originalStack);
+
+      console.error(
+        `\n${message}\n` +
+          formatStackTrace(stack, this._config, {noStackTrace: false}),
+      );
+      process.exitCode = 1;
+      return;
+    }
+
+    const wrapper = runScript[ScriptTransformer.EVAL_RESULT_VARIABLE];
     wrapper.call(
       localModule.exports, // module context
       localModule, // module object