diff --git a/ports/zydis/portfile.cmake b/ports/zydis/portfile.cmake
index fe635961ceb5af..a07d6d8729d682 100644
--- a/ports/zydis/portfile.cmake
+++ b/ports/zydis/portfile.cmake
@@ -1,19 +1,13 @@
-vcpkg_download_distfile(
-    OSX_INTEL_ALIGNMENT_FIX
-    URLS https://github.com/zyantific/zydis/commit/a605f54580c26d2164530fab323057834569d169.patch?full_index=1
-    SHA512 15fad10e4880ab2ee494babc0451b96604a6cc00c09c6740c6b97b83718e01d8e117614bf8f9ec8a6777e9baa1336c7f540709b21dcdc9b53f912bd117f1d3c0
-    FILENAME zydis-intel-alignment-fix-a605f54580c26d2164530fab323057834569d169.patch
-)
 
 vcpkg_from_github(
     OUT_SOURCE_PATH SOURCE_PATH
     REPO zyantific/zydis
     REF "v${VERSION}"
-    SHA512 334284bccfb6ce61cc530fd479d6278db3e4df1fb52b311acd7d21558843c9bf14e74a199cd937041d434260b65c506c07ae1a37243d2240eb9443ae5e56e000
+    SHA512 e07add4d43768ded02a238911fde6e74d2391abf8df282f774fca1a8c3fca3e97b03e90e0f3c7c0f3c75485fb29c0be4071d5e5b2e23dd5b8b1a864e3b713fbc
     HEAD_REF master
     PATCHES
         zycore.patch
-        "${OSX_INTEL_ALIGNMENT_FIX}"
+
 )
 
 string(COMPARE EQUAL "${VCPKG_LIBRARY_LINKAGE}" "dynamic" ZYDIS_BUILD_SHARED_LIB)
@@ -21,8 +15,11 @@ string(COMPARE EQUAL "${VCPKG_LIBRARY_LINKAGE}" "dynamic" ZYDIS_BUILD_SHARED_LIB
 vcpkg_cmake_configure(
     SOURCE_PATH "${SOURCE_PATH}"
     OPTIONS
+        -DZYAN_SYSTEM_ZYCORE=ON
         -DZYDIS_BUILD_SHARED_LIB=${ZYDIS_BUILD_SHARED_LIB}
+        -DZYDIS_BUILD_DOXYGEN=OFF
         -DZYDIS_BUILD_EXAMPLES=OFF
+        -DZYDIS_BUILD_TESTS=OFF
     OPTIONS_DEBUG
         -DZYDIS_BUILD_TOOLS=OFF
 )
@@ -34,7 +31,6 @@ vcpkg_cmake_config_fixup(CONFIG_PATH lib/cmake/zydis)
 vcpkg_copy_tools(TOOL_NAMES ZydisDisasm ZydisInfo AUTO_CLEAN)
 
 if(VCPKG_LIBRARY_LINKAGE STREQUAL static)
-    file(REMOVE_RECURSE "${CURRENT_PACKAGES_DIR}/bin" "${CURRENT_PACKAGES_DIR}/debug/bin")
     vcpkg_replace_string("${CURRENT_PACKAGES_DIR}/include/Zydis/Defines.h" "defined(ZYDIS_STATIC_BUILD)" "1")
 endif()
 
diff --git a/ports/zydis/vcpkg.json b/ports/zydis/vcpkg.json
index c9459b1d9a1936..6cc61cfb156ca3 100644
--- a/ports/zydis/vcpkg.json
+++ b/ports/zydis/vcpkg.json
@@ -1,7 +1,6 @@
 {
   "name": "zydis",
-  "version-semver": "4.0.0",
-  "port-version": 2,
+  "version-semver": "4.1.0",
   "description": "Fast and lightweight x86/x86-64 disassembler library.",
   "homepage": "https://zydis.re",
   "license": "MIT",
diff --git a/ports/zydis/zycore.patch b/ports/zydis/zycore.patch
index 5e62c7f29c4513..503daa2a898c11 100644
--- a/ports/zydis/zycore.patch
+++ b/ports/zydis/zycore.patch
@@ -1,66 +1,14 @@
-diff --git a/CMakeLists.txt b/CMakeLists.txt
-index 5e812fb..64c6e97 100644
---- a/CMakeLists.txt
-+++ b/CMakeLists.txt
-@@ -78,8 +78,7 @@ if (ZYAN_SYSTEM_ZYCORE)
-     find_package(Zycore)
- else ()
-     # Try to initialize the Zycore submodule using Git
--    if (NOT EXISTS "${ZYAN_ZYCORE_PATH}/CMakeLists.txt" AND 
--        "${ZYAN_ZYCORE_PATH}" STREQUAL "${CMAKE_CURRENT_LIST_DIR}/dependencies/zycore")
-+    if (0)
-         find_package(Git QUIET)
-         if(GIT_FOUND AND EXISTS "${PROJECT_SOURCE_DIR}/.git")
-             execute_process(
-@@ -89,7 +88,7 @@ else ()
-         endif()
-     endif ()
- 
--    if (NOT EXISTS "${ZYAN_ZYCORE_PATH}/CMakeLists.txt")
-+    if (0)
-         message(
-             FATAL_ERROR
-             "Can't find zycore submodule. Please make sure to clone the repo recursively.\n"
-@@ -101,7 +100,7 @@ else ()
-         )
-     endif ()
- 
--    add_subdirectory(${ZYAN_ZYCORE_PATH} "zycore" EXCLUDE_FROM_ALL)
-+    find_package(zycore CONFIG REQUIRED)
- endif ()
- 
- # =============================================================================================== #
-@@ -115,7 +114,7 @@ else ()
-     target_compile_definitions("Zydis" PUBLIC "ZYDIS_STATIC_BUILD")
- endif ()
- 
--target_link_libraries("Zydis" PUBLIC "Zycore")
-+target_link_libraries("Zydis" PUBLIC Zycore::Zycore)
- target_include_directories("Zydis"
-     PUBLIC
-         $<BUILD_INTERFACE:${CMAKE_CURRENT_SOURCE_DIR}/include>
-@@ -383,14 +382,16 @@ if (ZYDIS_BUILD_TOOLS AND NOT ZYAN_NO_LIBC)
-                 target_compile_definitions("ZydisFuzzReEncoding" PRIVATE "ZYDIS_LIBFUZZER")
-             endif ()
- 
--            add_executable("ZydisTestEncoderAbsolute"
--                "tools/ZydisTestEncoderAbsolute.c")
--            target_link_libraries("ZydisTestEncoderAbsolute" "Zydis")
--            set_target_properties("ZydisTestEncoderAbsolute" PROPERTIES FOLDER "Tools")
--            target_compile_definitions("ZydisTestEncoderAbsolute" PRIVATE "_CRT_SECURE_NO_WARNINGS")
--            zyan_set_common_flags("ZydisTestEncoderAbsolute")
--            zyan_maybe_enable_wpo("ZydisTestEncoderAbsolute")
--            _maybe_set_emscripten_cfg("ZydisTestEncoderAbsolute")
-+            if (NOT ZYDIS_BUILD_SHARED_LIB)
-+                add_executable("ZydisTestEncoderAbsolute"
-+                    "tools/ZydisTestEncoderAbsolute.c")
-+                target_link_libraries("ZydisTestEncoderAbsolute" "Zydis")
-+                set_target_properties("ZydisTestEncoderAbsolute" PROPERTIES FOLDER "Tools")
-+                target_compile_definitions("ZydisTestEncoderAbsolute" PRIVATE "_CRT_SECURE_NO_WARNINGS")
-+                zyan_set_common_flags("ZydisTestEncoderAbsolute")
-+                zyan_maybe_enable_wpo("ZydisTestEncoderAbsolute")
-+                _maybe_set_emscripten_cfg("ZydisTestEncoderAbsolute")
-+            endif ()
-         endif ()
- 
-         add_executable("ZydisInfo" "tools/ZydisInfo.c")
+diff --git a/CMakeLists.txt b/CMakeLists.txt
+index 62d5de6..ee500c7 100644
+--- a/CMakeLists.txt
++++ b/CMakeLists.txt
+@@ -138,7 +138,8 @@ function (locate_zycore)
+     )
+ endfunction ()
+ 
+-locate_zycore()
++find_package(zycore CONFIG REQUIRED)
++add_library(Zycore ALIAS Zycore::Zycore)
+ 
+ # =============================================================================================== #
+ # Library configuration                                                                           #
diff --git a/versions/baseline.json b/versions/baseline.json
index 7fc61e78ad5797..359f6752a1508f 100644
--- a/versions/baseline.json
+++ b/versions/baseline.json
@@ -9733,8 +9733,8 @@
       "port-version": 0
     },
     "zydis": {
-      "baseline": "4.0.0",
-      "port-version": 2
+      "baseline": "4.1.0",
+      "port-version": 0
     },
     "zyre": {
       "baseline": "2019-07-07",
diff --git a/versions/z-/zydis.json b/versions/z-/zydis.json
index 60a5fe1bf0560e..073e577b29f3e1 100644
--- a/versions/z-/zydis.json
+++ b/versions/z-/zydis.json
@@ -1,5 +1,10 @@
 {
   "versions": [
+    {
+      "git-tree": "a08c5c766c41651280cb783e5dd0a8a5764f9700",
+      "version-semver": "4.1.0",
+      "port-version": 0
+    },
     {
       "git-tree": "4057692f573c3990f5767e5e2952fc54a76cb1c9",
       "version-semver": "4.0.0",