diff --git a/ports/botan/portfile.cmake b/ports/botan/portfile.cmake
index bfc7db36e49f90..ab66cf27532109 100644
--- a/ports/botan/portfile.cmake
+++ b/ports/botan/portfile.cmake
@@ -162,4 +162,8 @@ if(VCPKG_LIBRARY_LINKAGE STREQUAL static)
     file(REMOVE_RECURSE "${CURRENT_PACKAGES_DIR}/bin" "${CURRENT_PACKAGES_DIR}/debug/bin")
 endif()
 
+vcpkg_replace_string("${CURRENT_PACKAGES_DIR}/include/botan/build.h" "#define BOTAN_INSTALL_PREFIX R\"(${CURRENT_PACKAGES_DIR})\"" "")
+vcpkg_replace_string("${CURRENT_PACKAGES_DIR}/include/botan/build.h" "#define BOTAN_INSTALL_LIB_DIR R\"(${CURRENT_PACKAGES_DIR}/lib)\"" "")
+vcpkg_replace_string("${CURRENT_PACKAGES_DIR}/include/botan/build.h" "--prefix=${CURRENT_PACKAGES_DIR}" "")
+
 file(INSTALL "${SOURCE_PATH}/license.txt" DESTINATION "${CURRENT_PACKAGES_DIR}/share/${PORT}" RENAME copyright)
diff --git a/ports/botan/vcpkg.json b/ports/botan/vcpkg.json
index 01891cc6a8ba08..1c2d7e1a30ebb2 100644
--- a/ports/botan/vcpkg.json
+++ b/ports/botan/vcpkg.json
@@ -1,7 +1,7 @@
 {
   "name": "botan",
   "version": "2.18.1",
-  "port-version": 3,
+  "port-version": 4,
   "description": "A cryptography library written in C++11",
   "homepage": "https://botan.randombit.net",
   "supports": "!(windows & arm)",
diff --git a/versions/b-/botan.json b/versions/b-/botan.json
index 78fde907139926..8e96e8fe522916 100644
--- a/versions/b-/botan.json
+++ b/versions/b-/botan.json
@@ -1,5 +1,10 @@
 {
   "versions": [
+    {
+      "git-tree": "477e259691b81a016da459532f616b5fca230a91",
+      "version": "2.18.1",
+      "port-version": 4
+    },
     {
       "git-tree": "045c95bf0e7f1352d91398bc0dc41ce5ec5a288a",
       "version": "2.18.1",
diff --git a/versions/baseline.json b/versions/baseline.json
index c9954604624a93..b8eee9ba683465 100644
--- a/versions/baseline.json
+++ b/versions/baseline.json
@@ -1130,7 +1130,7 @@
     },
     "botan": {
       "baseline": "2.18.1",
-      "port-version": 3
+      "port-version": 4
     },
     "box2d": {
       "baseline": "2.4.1",