diff --git a/ports/grpc/00005-fix-uwp-error.patch b/ports/grpc/00005-fix-uwp-error.patch
index fb49684295abb0..b70b0967ab8f3d 100644
--- a/ports/grpc/00005-fix-uwp-error.patch
+++ b/ports/grpc/00005-fix-uwp-error.patch
@@ -1,47 +1,47 @@
-diff --git a/src/core/ext/transport/chttp2/transport/hpack_parser.cc b/src/core/ext/transport/chttp2/transport/hpack_parser.cc
-index cb17759bba..a3c3598430 100644
---- a/src/core/ext/transport/chttp2/transport/hpack_parser.cc
-+++ b/src/core/ext/transport/chttp2/transport/hpack_parser.cc
-@@ -1032,7 +1032,7 @@ class HPackParser::Parser {
- 
-  private:
-   void GPR_ATTRIBUTE_NOINLINE LogHeader(const HPackTable::Memento& memento) {
--    const char* type;
-+    const char* type = nullptr;
-     switch (log_info_.type) {
-       case LogInfo::kHeaders:
-         type = "HDR";
-diff --git a/src/core/lib/slice/slice.cc b/src/core/lib/slice/slice.cc
-index 2e78b4de9e..77e88cab70 100644
---- a/src/core/lib/slice/slice.cc
-+++ b/src/core/lib/slice/slice.cc
-@@ -181,6 +181,7 @@ grpc_slice grpc_slice_from_moved_buffer(grpc_core::UniquePtr<char> p,
-                                         size_t len) {
-   uint8_t* ptr = reinterpret_cast<uint8_t*>(p.get());
-   grpc_slice slice;
-+  memset(&slice, 0, sizeof(grpc_slice));
-   if (len <= sizeof(slice.data.inlined.bytes)) {
-     slice.refcount = nullptr;
-     slice.data.inlined.length = len;
-@@ -199,7 +200,7 @@ grpc_slice grpc_slice_from_moved_string(grpc_core::UniquePtr<char> p) {
- }
- 
- grpc_slice grpc_slice_from_cpp_string(std::string str) {
--  grpc_slice slice;
-+  grpc_slice slice = { 0 };
-   if (str.size() <= sizeof(slice.data.inlined.bytes)) {
-     slice.refcount = nullptr;
-     slice.data.inlined.length = str.size();
-diff --git a/src/core/lib/surface/server.cc b/src/core/lib/surface/server.cc
-index 4c0220837e..bb5a367107 100644
---- a/src/core/lib/surface/server.cc
-+++ b/src/core/lib/surface/server.cc
-@@ -902,7 +902,7 @@ grpc_call_error Server::QueueRequestedCall(size_t cq_idx, RequestedCall* rc) {
-              GRPC_ERROR_CREATE_FROM_STATIC_STRING("Server Shutdown"));
-     return GRPC_CALL_OK;
-   }
--  RequestMatcherInterface* rm;
-+  RequestMatcherInterface* rm = nullptr;
-   switch (rc->type) {
-     case RequestedCall::Type::BATCH_CALL:
-       rm = unregistered_request_matcher_.get();
+diff --git a/src/core/ext/transport/chttp2/transport/hpack_parser.cc b/src/core/ext/transport/chttp2/transport/hpack_parser.cc
+index cb17759bba..a3c3598430 100644
+--- a/src/core/ext/transport/chttp2/transport/hpack_parser.cc
++++ b/src/core/ext/transport/chttp2/transport/hpack_parser.cc
+@@ -1032,7 +1032,7 @@ class HPackParser::Parser {
+
+  private:
+   void GPR_ATTRIBUTE_NOINLINE LogHeader(const HPackTable::Memento& memento) {
+-    const char* type;
++    const char* type = nullptr;
+     switch (log_info_.type) {
+       case LogInfo::kHeaders:
+         type = "HDR";
+diff --git a/src/core/lib/slice/slice.cc b/src/core/lib/slice/slice.cc
+index 2e78b4de9e..77e88cab70 100644
+--- a/src/core/lib/slice/slice.cc
++++ b/src/core/lib/slice/slice.cc
+@@ -181,6 +181,7 @@ grpc_slice grpc_slice_from_moved_buffer(grpc_core::UniquePtr<char> p,
+                                         size_t len) {
+   uint8_t* ptr = reinterpret_cast<uint8_t*>(p.get());
+   grpc_slice slice;
++  memset(&slice, 0, sizeof(grpc_slice));
+   if (len <= sizeof(slice.data.inlined.bytes)) {
+     slice.refcount = nullptr;
+     slice.data.inlined.length = len;
+@@ -199,7 +200,7 @@ grpc_slice grpc_slice_from_moved_string(grpc_core::UniquePtr<char> p) {
+ }
+
+ grpc_slice grpc_slice_from_cpp_string(std::string str) {
+-  grpc_slice slice;
++  grpc_slice slice = { 0 };
+   if (str.size() <= sizeof(slice.data.inlined.bytes)) {
+     slice.refcount = nullptr;
+     slice.data.inlined.length = str.size();
+diff --git a/src/core/lib/surface/server.cc b/src/core/lib/surface/server.cc
+index 4c0220837e..bb5a367107 100644
+--- a/src/core/lib/surface/server.cc
++++ b/src/core/lib/surface/server.cc
+@@ -902,7 +902,7 @@ grpc_call_error Server::QueueRequestedCall(size_t cq_idx, RequestedCall* rc) {
+              GRPC_ERROR_CREATE_FROM_STATIC_STRING("Server Shutdown"));
+     return GRPC_CALL_OK;
+   }
+-  RequestMatcherInterface* rm;
++  RequestMatcherInterface* rm = nullptr;
+   switch (rc->type) {
+     case RequestedCall::Type::BATCH_CALL:
+       rm = unregistered_request_matcher_.get();
diff --git a/ports/grpc/00009-use-system-upb.patch b/ports/grpc/00009-use-system-upb.patch
index 35d936e473de1d..8bafe8452b2eb8 100644
--- a/ports/grpc/00009-use-system-upb.patch
+++ b/ports/grpc/00009-use-system-upb.patch
@@ -1,91 +1,91 @@
-diff --git a/CMakeLists.txt b/CMakeLists.txt
-index 8498b6e435..12d50a26ff 100644
---- a/CMakeLists.txt
-+++ b/CMakeLists.txt
-@@ -85,6 +85,9 @@ set_property(CACHE gRPC_SSL_PROVIDER PROPERTY STRINGS "module" "package")
- set(gRPC_PROTOBUF_PROVIDER "module" CACHE STRING "Provider of protobuf library")
- set_property(CACHE gRPC_PROTOBUF_PROVIDER PROPERTY STRINGS "module" "package")
- 
-+set(gRPC_UPB_PROVIDER "module" CACHE STRING "Provider of upb library")
-+set_property(CACHE gRPC_UPB_PROVIDER PROPERTY STRINGS "module" "package")
-+
- set(gRPC_PROTOBUF_PACKAGE_TYPE "" CACHE STRING "Algorithm for searching protobuf package")
- set_property(CACHE gRPC_PROTOBUF_PACKAGE_TYPE PROPERTY STRINGS "CONFIG" "MODULE")
- 
-@@ -1596,6 +1599,7 @@ target_link_libraries(gpr
-   absl::time
-   absl::optional
-   absl::variant
-+  ${_gRPC_UPB_LIBRARIES}
- )
- if(_gRPC_PLATFORM_ANDROID)
-   target_link_libraries(gpr
-@@ -2400,7 +2404,6 @@ target_link_libraries(grpc
-   gpr
-   ${_gRPC_SSL_LIBRARIES}
-   address_sorting
--  upb
- )
- if(_gRPC_PLATFORM_IOS OR _gRPC_PLATFORM_MAC)
-   target_link_libraries(grpc "-framework CoreFoundation")
-@@ -2961,7 +2964,6 @@ target_link_libraries(grpc_unsecure
-   absl::utility
-   gpr
-   address_sorting
--  upb
- )
- if(_gRPC_PLATFORM_IOS OR _gRPC_PLATFORM_MAC)
-   target_link_libraries(grpc_unsecure "-framework CoreFoundation")
-@@ -4254,6 +4256,7 @@ endif()
- 
- endif()
- 
-+if (gRPC_UPB_PROVIDER STREQUAL "module")
- add_library(upb
-   third_party/upb/third_party/utf8_range/naive.c
-   third_party/upb/third_party/utf8_range/range2-neon.c
-@@ -4322,7 +4325,7 @@ if(gRPC_INSTALL)
-     ARCHIVE DESTINATION ${gRPC_INSTALL_LIBDIR}
-   )
- endif()
--
-+endif()
- 
- 
- add_executable(gen_hpack_tables
-diff --git a/cmake/gRPCConfig.cmake.in b/cmake/gRPCConfig.cmake.in
-index 3623f4aa5e..df6ced560e 100644
---- a/cmake/gRPCConfig.cmake.in
-+++ b/cmake/gRPCConfig.cmake.in
-@@ -8,6 +8,7 @@ list(APPEND CMAKE_MODULE_PATH ${CMAKE_CURRENT_LIST_DIR}/modules)
- @_gRPC_FIND_CARES@
- @_gRPC_FIND_ABSL@
- @_gRPC_FIND_RE2@
-+@_gRPC_FIND_UPB@
- 
- # Targets
- include(${CMAKE_CURRENT_LIST_DIR}/gRPCTargets.cmake)
-diff --git a/cmake/upb.cmake b/cmake/upb.cmake
-index f2a0e508c3..09751f5ef0 100644
---- a/cmake/upb.cmake
-+++ b/cmake/upb.cmake
-@@ -12,9 +12,19 @@
- # See the License for the specific language governing permissions and
- # limitations under the License.
- 
-+set(_gRPC_UPB_GRPC_GENERATED_DIR "${CMAKE_CURRENT_SOURCE_DIR}/src/core/ext/upb-generated" "${CMAKE_CURRENT_SOURCE_DIR}/src/core/ext/upbdefs-generated")
-+if (gRPC_UPB_PROVIDER STREQUAL "module")
-+
- set(UPB_ROOT_DIR ${CMAKE_CURRENT_SOURCE_DIR}/third_party/upb)
- 
- set(_gRPC_UPB_INCLUDE_DIR "${UPB_ROOT_DIR}")
- set(_gRPC_UPB_GRPC_GENERATED_DIR "${CMAKE_CURRENT_SOURCE_DIR}/src/core/ext/upb-generated" "${CMAKE_CURRENT_SOURCE_DIR}/src/core/ext/upbdefs-generated")
- 
- set(_gRPC_UPB_LIBRARIES upb)
-+
-+elseif(gRPC_UPB_PROVIDER STREQUAL "package")
-+    find_package(upb CONFIG REQUIRED)
-+    set(_gRPC_UPB_LIBRARIES upb::fastdecode upb::json upb::upb upb::utf8_range upb::textformat upb::reflection upb::descriptor_upb_proto)
-+    set(_gRPC_UPB_INCLUDE_DIR)
-+    set(_gRPC_FIND_UPB "if(NOT upb_FOUND)\n  find_package(upb CONFIG REQUIRED)\nendif()")
-+endif()
+diff --git a/CMakeLists.txt b/CMakeLists.txt
+index 23098aa578..a8e8bc274b 100644
+--- a/CMakeLists.txt
++++ b/CMakeLists.txt
+@@ -85,6 +85,9 @@ set_property(CACHE gRPC_SSL_PROVIDER PROPERTY STRINGS "module" "package")
+ set(gRPC_PROTOBUF_PROVIDER "module" CACHE STRING "Provider of protobuf library")
+ set_property(CACHE gRPC_PROTOBUF_PROVIDER PROPERTY STRINGS "module" "package")
+
++set(gRPC_UPB_PROVIDER "module" CACHE STRING "Provider of upb library")
++set_property(CACHE gRPC_UPB_PROVIDER PROPERTY STRINGS "module" "package")
++
+ set(gRPC_PROTOBUF_PACKAGE_TYPE "" CACHE STRING "Algorithm for searching protobuf package")
+ set_property(CACHE gRPC_PROTOBUF_PACKAGE_TYPE PROPERTY STRINGS "CONFIG" "MODULE")
+
+@@ -1631,6 +1634,7 @@ target_link_libraries(gpr
+   absl::time
+   absl::optional
+   absl::variant
++  ${_gRPC_UPB_LIBRARIES}
+ )
+ if(_gRPC_PLATFORM_ANDROID)
+   target_link_libraries(gpr
+@@ -2435,7 +2439,6 @@ target_link_libraries(grpc
+   gpr
+   ${_gRPC_SSL_LIBRARIES}
+   address_sorting
+-  upb
+ )
+ if(_gRPC_PLATFORM_IOS OR _gRPC_PLATFORM_MAC)
+   target_link_libraries(grpc "-framework CoreFoundation")
+@@ -2979,7 +2982,6 @@ target_link_libraries(grpc_unsecure
+   absl::utility
+   gpr
+   address_sorting
+-  upb
+ )
+ if(_gRPC_PLATFORM_IOS OR _gRPC_PLATFORM_MAC)
+   target_link_libraries(grpc_unsecure "-framework CoreFoundation")
+@@ -4251,6 +4253,7 @@ endif()
+
+ endif()
+
++if (gRPC_UPB_PROVIDER STREQUAL "module")
+ add_library(upb
+   third_party/upb/third_party/utf8_range/naive.c
+   third_party/upb/third_party/utf8_range/range2-neon.c
+@@ -4319,7 +4322,7 @@ if(gRPC_INSTALL)
+     ARCHIVE DESTINATION ${gRPC_INSTALL_LIBDIR}
+   )
+ endif()
+-
++endif()
+
+ if(gRPC_BUILD_TESTS)
+
+diff --git a/cmake/gRPCConfig.cmake.in b/cmake/gRPCConfig.cmake.in
+index 3623f4aa5e..df6ced560e 100644
+--- a/cmake/gRPCConfig.cmake.in
++++ b/cmake/gRPCConfig.cmake.in
+@@ -8,6 +8,7 @@ list(APPEND CMAKE_MODULE_PATH ${CMAKE_CURRENT_LIST_DIR}/modules)
+ @_gRPC_FIND_CARES@
+ @_gRPC_FIND_ABSL@
+ @_gRPC_FIND_RE2@
++@_gRPC_FIND_UPB@
+
+ # Targets
+ include(${CMAKE_CURRENT_LIST_DIR}/gRPCTargets.cmake)
+diff --git a/cmake/upb.cmake b/cmake/upb.cmake
+index f2a0e508c3..09751f5ef0 100644
+--- a/cmake/upb.cmake
++++ b/cmake/upb.cmake
+@@ -12,9 +12,19 @@
+ # See the License for the specific language governing permissions and
+ # limitations under the License.
+
++set(_gRPC_UPB_GRPC_GENERATED_DIR "${CMAKE_CURRENT_SOURCE_DIR}/src/core/ext/upb-generated" "${CMAKE_CURRENT_SOURCE_DIR}/src/core/ext/upbdefs-generated")
++if (gRPC_UPB_PROVIDER STREQUAL "module")
++
+ set(UPB_ROOT_DIR ${CMAKE_CURRENT_SOURCE_DIR}/third_party/upb)
+
+ set(_gRPC_UPB_INCLUDE_DIR "${UPB_ROOT_DIR}")
+ set(_gRPC_UPB_GRPC_GENERATED_DIR "${CMAKE_CURRENT_SOURCE_DIR}/src/core/ext/upb-generated" "${CMAKE_CURRENT_SOURCE_DIR}/src/core/ext/upbdefs-generated")
+
+ set(_gRPC_UPB_LIBRARIES upb)
++
++elseif(gRPC_UPB_PROVIDER STREQUAL "package")
++    find_package(upb CONFIG REQUIRED)
++    set(_gRPC_UPB_LIBRARIES upb::fastdecode upb::json upb::upb upb::utf8_range upb::textformat upb::reflection upb::descriptor_upb_proto)
++    set(_gRPC_UPB_INCLUDE_DIR)
++    set(_gRPC_FIND_UPB "if(NOT upb_FOUND)\n  find_package(upb CONFIG REQUIRED)\nendif()")
++endif()
diff --git a/ports/grpc/00012-fix-use-cxx17.patch b/ports/grpc/00012-fix-use-cxx17.patch
index 57af77625726b6..56bc4367608e2c 100644
--- a/ports/grpc/00012-fix-use-cxx17.patch
+++ b/ports/grpc/00012-fix-use-cxx17.patch
@@ -1,16 +1,16 @@
-diff --git a/CMakeLists.txt b/CMakeLists.txt
-index 25990a5d8a..ba8df92858 100644
---- a/CMakeLists.txt
-+++ b/CMakeLists.txt
-@@ -326,6 +326,11 @@ include(cmake/xxhash.cmake)
- include(cmake/zlib.cmake)
- include(cmake/download_archive.cmake)
- 
-+if (ABSL_USE_CXX17)
-+    message(STATUS "Found absl uses CXX17, enable CXX17 feature.")
-+    set(CMAKE_CXX_STANDARD 17)
-+endif()
-+
- # Setup external proto library at third_party/envoy-api with 2 download URLs
- if (NOT EXISTS ${CMAKE_CURRENT_SOURCE_DIR}/third_party/envoy-api)
-   # Download the archive via HTTP, validate the checksum, and extract to third_party/envoy-api.
+diff --git a/CMakeLists.txt b/CMakeLists.txt
+index 25990a5d8a..ba8df92858 100644
+--- a/CMakeLists.txt
++++ b/CMakeLists.txt
+@@ -326,6 +326,11 @@ include(cmake/xxhash.cmake)
+ include(cmake/zlib.cmake)
+ include(cmake/download_archive.cmake)
+
++if (ABSL_USE_CXX17)
++    message(STATUS "Found absl uses CXX17, enable CXX17 feature.")
++    set(CMAKE_CXX_STANDARD 17)
++endif()
++
+ # Setup external proto library at third_party/envoy-api with 2 download URLs
+ if (NOT EXISTS ${CMAKE_CURRENT_SOURCE_DIR}/third_party/envoy-api)
+   # Download the archive via HTTP, validate the checksum, and extract to third_party/envoy-api.
diff --git a/ports/grpc/gRPCTargets-vcpkg-tools.cmake b/ports/grpc/gRPCTargets-vcpkg-tools.cmake
index 08e3ee3afc4011..1ed3509c940800 100644
--- a/ports/grpc/gRPCTargets-vcpkg-tools.cmake
+++ b/ports/grpc/gRPCTargets-vcpkg-tools.cmake
@@ -1,10 +1,10 @@
-file(GLOB GRPC_PLUGINS "${_IMPORT_PREFIX}/../@HOST_TRIPLET@/tools/grpc/grpc_*_plugin*")
-
-foreach(PLUGIN ${GRPC_PLUGINS})
-  get_filename_component(PLUGIN_NAME "${PLUGIN}" NAME_WE)
-  add_executable(gRPC::${PLUGIN_NAME} IMPORTED)
-  set_property(TARGET gRPC::${PLUGIN_NAME} APPEND PROPERTY IMPORTED_CONFIGURATIONS RELEASE)
-  set_target_properties(gRPC::${PLUGIN_NAME} PROPERTIES
-    IMPORTED_LOCATION_RELEASE "${PLUGIN}"
-  )
-endforeach()
+file(GLOB GRPC_PLUGINS "${_IMPORT_PREFIX}/../@HOST_TRIPLET@/tools/grpc/grpc_*_plugin*")
+
+foreach(PLUGIN ${GRPC_PLUGINS})
+  get_filename_component(PLUGIN_NAME "${PLUGIN}" NAME_WE)
+  add_executable(gRPC::${PLUGIN_NAME} IMPORTED)
+  set_property(TARGET gRPC::${PLUGIN_NAME} APPEND PROPERTY IMPORTED_CONFIGURATIONS RELEASE)
+  set_target_properties(gRPC::${PLUGIN_NAME} PROPERTIES
+    IMPORTED_LOCATION_RELEASE "${PLUGIN}"
+  )
+endforeach()
diff --git a/ports/grpc/portfile.cmake b/ports/grpc/portfile.cmake
index 5936a2f7dbc37c..b4060a043fd49e 100644
--- a/ports/grpc/portfile.cmake
+++ b/ports/grpc/portfile.cmake
@@ -5,8 +5,8 @@ endif()
 vcpkg_from_github(
     OUT_SOURCE_PATH SOURCE_PATH
     REPO grpc/grpc
-    REF v1.49.0
-    SHA512 592413f0f907ec5c7c6b22366e418c589a653ef105b61bf0f98fc64dc40ccea0d2fadc9af9ade62bffa99cafec6e1305300cb9531202923614fe308b7f831210
+    REF v1.50.1
+    SHA512 7c90ec9fd073980218f69eda704dbfb526dbd2f7f864135bdc6bd064789d1d8889127a253493196e617b0b90dddf1204ca9344c5e585ab0f0ca5c2a2a0a22ef1
     HEAD_REF master
     PATCHES
         00001-fix-uwp.patch
diff --git a/ports/grpc/vcpkg.json b/ports/grpc/vcpkg.json
index 6fe26b8c405097..014755eabab908 100644
--- a/ports/grpc/vcpkg.json
+++ b/ports/grpc/vcpkg.json
@@ -1,6 +1,6 @@
 {
   "name": "grpc",
-  "version-semver": "1.49.0",
+  "version-semver": "1.50.1",
   "description": "An RPC library and framework",
   "homepage": "https://github.com/grpc/grpc",
   "license": "Apache-2.0",
diff --git a/versions/baseline.json b/versions/baseline.json
index a10aafdb9a2bc4..5a78f339b66ea8 100644
--- a/versions/baseline.json
+++ b/versions/baseline.json
@@ -2761,7 +2761,7 @@
       "port-version": 0
     },
     "grpc": {
-      "baseline": "1.49.0",
+      "baseline": "1.50.1",
       "port-version": 0
     },
     "grppi": {
diff --git a/versions/g-/grpc.json b/versions/g-/grpc.json
index 9d8e0d4f8e2dcc..6e49e7d0474447 100644
--- a/versions/g-/grpc.json
+++ b/versions/g-/grpc.json
@@ -1,5 +1,10 @@
 {
   "versions": [
+    {
+      "git-tree": "13420572b45b2b5a5a3fb41eb383d0c62f1d7c51",
+      "version-semver": "1.50.1",
+      "port-version": 0
+    },
     {
       "git-tree": "28334108999e49da12dbde24bcfc183984ecef41",
       "version-semver": "1.49.0",