diff --git a/docs/pages/api-docs/native-select.json b/docs/pages/api-docs/native-select.json
index 1e6df9459fada5..328c6493e2cda1 100644
--- a/docs/pages/api-docs/native-select.json
+++ b/docs/pages/api-docs/native-select.json
@@ -6,6 +6,7 @@
     "input": { "type": { "name": "element" }, "default": "<Input />" },
     "inputProps": { "type": { "name": "object" } },
     "onChange": { "type": { "name": "func" } },
+    "sx": { "type": { "name": "object" } },
     "value": { "type": { "name": "any" } },
     "variant": {
       "type": {
@@ -37,6 +38,6 @@
   "filename": "/packages/material-ui/src/NativeSelect/NativeSelect.js",
   "inheritance": { "component": "Input", "pathname": "/api/input/" },
   "demos": "<ul><li><a href=\"/components/selects/\">Selects</a></li></ul>",
-  "styledComponent": false,
+  "styledComponent": true,
   "cssComponent": false
 }
diff --git a/docs/translations/api-docs/native-select/native-select.json b/docs/translations/api-docs/native-select/native-select.json
index b303222f1c7269..eb51c78befe586 100644
--- a/docs/translations/api-docs/native-select/native-select.json
+++ b/docs/translations/api-docs/native-select/native-select.json
@@ -7,6 +7,7 @@
     "input": "An <code>Input</code> element; does not have to be a material-ui specific <code>Input</code>.",
     "inputProps": "&lt;a href=&quot;<a href=\"https://developer.mozilla.org/en-US/docs/Web/HTML/Element/input#Attributes&quot;&gt;Attributes&lt;/a&gt;\">https://developer.mozilla.org/en-US/docs/Web/HTML/Element/input#Attributes&quot;&gt;Attributes&lt;/a&gt;</a> applied to the <code>select</code> element.",
     "onChange": "Callback fired when a menu item is selected.<br><br><strong>Signature:</strong><br><code>function(event: object) =&gt; void</code><br><em>event:</em> The event source of the callback. You can pull out the new value by accessing <code>event.target.value</code> (string).",
+    "sx": "The system prop that allows defining system overrides as well as additional CSS styles. See the <a href=\"/system/basics/#the-sx-prop\">`sx` page</a> for more details.",
     "value": "The <code>input</code> value. The DOM API casts this to a string.",
     "variant": "The variant to use."
   },
diff --git a/packages/material-ui/src/NativeSelect/NativeSelect.d.ts b/packages/material-ui/src/NativeSelect/NativeSelect.d.ts
index fc2102f5edaadc..494b7132d4527e 100644
--- a/packages/material-ui/src/NativeSelect/NativeSelect.d.ts
+++ b/packages/material-ui/src/NativeSelect/NativeSelect.d.ts
@@ -1,5 +1,6 @@
 import * as React from 'react';
-import { InternalStandardProps as StandardProps } from '..';
+import { SxProps } from '@material-ui/system';
+import { InternalStandardProps as StandardProps, Theme } from '..';
 import { InputProps } from '../Input';
 import { NativeSelectInputProps } from './NativeSelectInput';
 
@@ -58,6 +59,10 @@ export interface NativeSelectProps
    * You can pull out the new value by accessing `event.target.value` (string).
    */
   onChange?: NativeSelectInputProps['onChange'];
+  /**
+   * The system prop that allows defining system overrides as well as additional CSS styles.
+   */
+  sx?: SxProps<Theme>;
   /**
    * The `input` value. The DOM API casts this to a string.
    */
diff --git a/packages/material-ui/src/NativeSelect/NativeSelect.js b/packages/material-ui/src/NativeSelect/NativeSelect.js
index f1c1beea345778..3e234c3a363954 100644
--- a/packages/material-ui/src/NativeSelect/NativeSelect.js
+++ b/packages/material-ui/src/NativeSelect/NativeSelect.js
@@ -1,11 +1,11 @@
 import * as React from 'react';
 import PropTypes from 'prop-types';
 import NativeSelectInput from './NativeSelectInput';
-import withStyles from '../styles/withStyles';
 import formControlState from '../FormControl/formControlState';
 import useFormControl from '../FormControl/useFormControl';
 import ArrowDropDownIcon from '../internal/svg-icons/ArrowDropDown';
 import Input from '../Input';
+import useThemeProps from '../styles/useThemeProps';
 
 export const styles = (theme) => ({
   /* Styles applied to the select component `root` class. */
@@ -62,7 +62,7 @@ export const styles = (theme) => ({
   },
   /* Styles applied to the select component `selectMenu` class. */
   selectMenu: {
-    height: 'auto', // Resets for multiple select with chips
+    height: 'auto', // Resets for multipile select with chips
     minHeight: '1.4375em', // Required for select\text-field height consistency
     textOverflow: 'ellipsis',
     whiteSpace: 'nowrap',
@@ -111,7 +111,8 @@ const defaultInput = <Input />;
 /**
  * An alternative to `<Select native />` with a much smaller bundle size footprint.
  */
-const NativeSelect = React.forwardRef(function NativeSelect(props, ref) {
+const NativeSelect = React.forwardRef(function NativeSelect(inProps, ref) {
+  const props = useThemeProps({ name: 'MuiNativeSelect', props: inProps });
   const {
     children,
     classes,
@@ -182,6 +183,10 @@ NativeSelect.propTypes /* remove-proptypes */ = {
    * You can pull out the new value by accessing `event.target.value` (string).
    */
   onChange: PropTypes.func,
+  /**
+   * The system prop that allows defining system overrides as well as additional CSS styles.
+   */
+  sx: PropTypes.object,
   /**
    * The `input` value. The DOM API casts this to a string.
    */
@@ -194,4 +199,4 @@ NativeSelect.propTypes /* remove-proptypes */ = {
 
 NativeSelect.muiName = 'Select';
 
-export default withStyles(styles, { name: 'MuiNativeSelect' })(NativeSelect);
+export default NativeSelect;
diff --git a/packages/material-ui/src/NativeSelect/NativeSelect.test.js b/packages/material-ui/src/NativeSelect/NativeSelect.test.js
index a393af5c7744a5..7a62ebfcbbdb96 100644
--- a/packages/material-ui/src/NativeSelect/NativeSelect.test.js
+++ b/packages/material-ui/src/NativeSelect/NativeSelect.test.js
@@ -1,12 +1,11 @@
 import * as React from 'react';
 import { expect } from 'chai';
-import { getClasses, createMount, createClientRender, describeConformance } from 'test/utils';
+import { createMount, createClientRender, describeConformanceV5 } from 'test/utils';
 import Input, { inputClasses } from '../Input';
 import NativeSelect from './NativeSelect';
+import classes from './nativeSelectClasses';
 
 describe('<NativeSelect />', () => {
-  let classes;
-
   const mount = createMount();
   const render = createClientRender();
   const defaultProps = {
@@ -21,16 +20,14 @@ describe('<NativeSelect />', () => {
     ],
   };
 
-  before(() => {
-    classes = getClasses(<NativeSelect {...defaultProps} />);
-  });
-
-  describeConformance(<NativeSelect {...defaultProps} />, () => ({
+  describeConformanceV5(<NativeSelect {...defaultProps} />, () => ({
     classes,
     inheritComponent: Input,
     mount,
+    render,
     refInstanceof: window.HTMLDivElement,
-    skip: ['componentProp', 'rootClass'],
+    muiName: 'MuiNativeSelect',
+    skip: ['componentProp', 'componentsProp', 'rootClass', 'themeVariants', 'themeStyleOverrides'],
   }));
 
   it('should render a native select', () => {
diff --git a/packages/material-ui/src/NativeSelect/NativeSelectInput.d.ts b/packages/material-ui/src/NativeSelect/NativeSelectInput.d.ts
index a95956e04eb089..67b344b1a97dc0 100644
--- a/packages/material-ui/src/NativeSelect/NativeSelectInput.d.ts
+++ b/packages/material-ui/src/NativeSelect/NativeSelectInput.d.ts
@@ -1,10 +1,13 @@
 import * as React from 'react';
+import { SxProps } from '@material-ui/system';
+import { Theme } from '..';
 
 export interface NativeSelectInputProps extends React.SelectHTMLAttributes<HTMLSelectElement> {
   disabled?: boolean;
   IconComponent?: React.ElementType;
   inputRef?: React.Ref<HTMLSelectElement>;
   variant?: 'standard' | 'outlined' | 'filled';
+  sx?: SxProps<Theme>;
 }
 
 declare const NativeSelectInput: React.ComponentType<NativeSelectInputProps>;
diff --git a/packages/material-ui/src/NativeSelect/NativeSelectInput.js b/packages/material-ui/src/NativeSelect/NativeSelectInput.js
index 2a359d93faf2b6..5cf8af18bc9977 100644
--- a/packages/material-ui/src/NativeSelect/NativeSelectInput.js
+++ b/packages/material-ui/src/NativeSelect/NativeSelectInput.js
@@ -1,45 +1,145 @@
 import * as React from 'react';
 import PropTypes from 'prop-types';
 import clsx from 'clsx';
-import { refType } from '@material-ui/utils';
+import { refType, deepmerge } from '@material-ui/utils';
+import { unstable_composeClasses as composeClasses } from '@material-ui/unstyled';
 import capitalize from '../utils/capitalize';
+import nativeSelectClasses, { getNativeSelectUtilitiyClasses } from './nativeSelectClasses';
+import experimentalStyled from '../styles/experimentalStyled';
+
+export const overridesResolver = (props, styles) => {
+  const { styleProps } = props;
+  return deepmerge(styles.root, {
+    ...styles.select,
+    ...styles[styleProps.variant],
+    [`& .${nativeSelectClasses.icon}`]: {
+      ...styles.icon,
+      ...(styleProps.variant && styles[`icon${capitalize(styleProps.variant)}`]),
+      ...(styleProps.open && styles.iconOpen),
+    },
+  });
+};
+
+const useUtilityClasses = (styleProps) => {
+  const { classes, variant, disabled, open } = styleProps;
+
+  const slots = {
+    root: ['root', 'select', variant, disabled && 'disabled'],
+    icon: ['icon', `icon${capitalize(variant)}`, open && 'iconOpen', disabled && 'disabled'],
+  };
+
+  return composeClasses(slots, getNativeSelectUtilitiyClasses, classes);
+};
+
+const SelectRoot = experimentalStyled(
+  'select',
+  {},
+  { name: 'MuiNativeSelect', slot: 'Root', overridesResolver },
+)(({ styleProps, theme }) => ({
+  MozAppearance: 'none', // Reset
+  WebkitAppearance: 'none', // Reset
+  // When interacting quickly, the text can end up selected.
+  // Native select can't be selected either.
+  userSelect: 'none',
+  borderRadius: 0, // Reset
+  minWidth: 16, // So it doesn't collapse.
+  cursor: 'pointer',
+  '&:focus': {
+    // Show that it's not an text input
+    backgroundColor:
+      theme.palette.mode === 'light' ? 'rgba(0, 0, 0, 0.05)' : 'rgba(255, 255, 255, 0.05)',
+    borderRadius: 0, // Reset Chrome style
+  },
+  // Remove IE11 arrow
+  '&::-ms-expand': {
+    display: 'none',
+  },
+  '&.Mui-disabled': {
+    cursor: 'default',
+  },
+  '&[multiple]': {
+    height: 'auto',
+  },
+  '&:not([multiple]) option, &:not([multiple]) optgroup': {
+    backgroundColor: theme.palette.background.paper,
+  },
+  // Bump specificity to allow extending custom inputs
+  '&&': {
+    paddingRight: 24,
+  },
+  ...(styleProps.variant === 'filled' && {
+    '&&': {
+      paddingRight: 32,
+    },
+  }),
+  ...(styleProps.variant === 'outlined' && {
+    borderRadius: theme.shape.borderRadius,
+    '&:focus': {
+      borderRadius: theme.shape.borderRadius, // Reset the reset for Chrome style
+    },
+    '&&': {
+      paddingRight: 32,
+    },
+  }),
+  ...(styleProps.selectMenu && {
+    height: 'auto', // Resets for multpile select with chips
+    minHeight: '1.4375em', // Required for select\text-field height consistency
+    textOverflow: 'ellipsis',
+    whiteSpace: 'nowrap',
+    overflow: 'hidden',
+  }),
+}));
+
+const IconRoot = experimentalStyled(
+  'svg',
+  {},
+  { name: 'MuiNativeSelect', slot: 'Icon' },
+)(({ styleProps, theme }) => ({
+  // We use a position absolute over a flexbox in order to forward the pointer events
+  // to the input and to support wrapping tags..
+  position: 'absolute',
+  right: 0,
+  top: 'calc(50% - 12px)', // Center vertically
+  pointerEvents: 'none', // Don't block pointer events on the select under the icon.
+  color: theme.palette.action.active,
+  '&.Mui-disabled': {
+    color: theme.palette.action.disabled,
+  },
+  ...(styleProps.open && {
+    right: 7,
+  }),
+  ...(styleProps.variant === 'filled' && {
+    right: 7,
+  }),
+  ...(styleProps.variant === 'outlined' && {
+    right: 7,
+  }),
+}));
 
 /**
  * @ignore - internal component.
  */
 const NativeSelectInput = React.forwardRef(function NativeSelectInput(props, ref) {
-  const {
-    classes,
-    className,
+  const { className, disabled, IconComponent, inputRef, variant = 'standard', ...other } = props;
+
+  const styleProps = {
+    ...props,
     disabled,
-    IconComponent,
-    inputRef,
-    variant = 'standard',
-    ...other
-  } = props;
+    variant,
+  };
 
+  const classes = useUtilityClasses(styleProps);
   return (
     <React.Fragment>
-      <select
-        className={clsx(
-          classes.root, // TODO v5: merge root and select
-          classes.select,
-          classes[variant],
-          {
-            [classes.disabled]: disabled,
-          },
-          className,
-        )}
+      <SelectRoot
+        styleProps={styleProps}
+        className={clsx(classes.root, className)}
         disabled={disabled}
         ref={inputRef || ref}
         {...other}
       />
       {props.multiple ? null : (
-        <IconComponent
-          className={clsx(classes.icon, classes[`icon${capitalize(variant)}`], {
-            [classes.disabled]: disabled,
-          })}
-        />
+        <IconRoot as={IconComponent} styleProps={styleProps} className={classes.icon} />
       )}
     </React.Fragment>
   );
@@ -55,7 +155,7 @@ NativeSelectInput.propTypes = {
    * Override or extend the styles applied to the component.
    * See [CSS API](#css) below for more details.
    */
-  classes: PropTypes.object.isRequired,
+  classes: PropTypes.object,
   /**
    * The CSS class name of the select element.
    */
diff --git a/packages/material-ui/src/NativeSelect/NativeSelectInput.test.js b/packages/material-ui/src/NativeSelect/NativeSelectInput.test.js
index 4d2044aa7e5249..563a5ce7f9e105 100644
--- a/packages/material-ui/src/NativeSelect/NativeSelectInput.test.js
+++ b/packages/material-ui/src/NativeSelect/NativeSelectInput.test.js
@@ -1,7 +1,7 @@
 import * as React from 'react';
 import { expect } from 'chai';
 import { spy } from 'sinon';
-import { createMount, describeConformance, createClientRender } from 'test/utils';
+import { createMount, describeConformanceV5, createClientRender } from 'test/utils';
 import NativeSelectInput from './NativeSelectInput';
 
 describe('<NativeSelectInput />', () => {
@@ -25,10 +25,11 @@ describe('<NativeSelectInput />', () => {
     ],
   };
 
-  describeConformance(<NativeSelectInput {...defaultProps} onChange={() => {}} />, () => ({
+  describeConformanceV5(<NativeSelectInput {...defaultProps} onChange={() => {}} />, () => ({
     mount,
     only: ['refForwarding'],
     refInstanceof: window.HTMLSelectElement,
+    muiName: 'MuiNativeSelectInput',
   }));
 
   it('should render a native select', () => {
diff --git a/packages/material-ui/src/NativeSelect/index.d.ts b/packages/material-ui/src/NativeSelect/index.d.ts
index b98e687a6d6fa1..026e02bdf5c8a9 100644
--- a/packages/material-ui/src/NativeSelect/index.d.ts
+++ b/packages/material-ui/src/NativeSelect/index.d.ts
@@ -1,2 +1,4 @@
 export { default } from './NativeSelect';
 export * from './NativeSelect';
+export { default as nativeSelectClasses } from './nativeSelectClasses';
+export * from './nativeSelectClasses';
diff --git a/packages/material-ui/src/NativeSelect/index.js b/packages/material-ui/src/NativeSelect/index.js
index e2f92130f3481e..1377cb53267a13 100644
--- a/packages/material-ui/src/NativeSelect/index.js
+++ b/packages/material-ui/src/NativeSelect/index.js
@@ -1 +1,3 @@
 export { default } from './NativeSelect';
+export { default as nativeSelectClasses } from './nativeSelectClasses';
+export * from './nativeSelectClasses';
diff --git a/packages/material-ui/src/NativeSelect/nativeSelectClasses.d.ts b/packages/material-ui/src/NativeSelect/nativeSelectClasses.d.ts
new file mode 100644
index 00000000000000..8f484a275c2fd0
--- /dev/null
+++ b/packages/material-ui/src/NativeSelect/nativeSelectClasses.d.ts
@@ -0,0 +1,7 @@
+import { NativeSelectClassKey } from './NativeSelect';
+
+declare const nativeSelectClasses: Record<NativeSelectClassKey, string>;
+
+export function getNativeSelectUtilityClasses(slot: string): string;
+
+export default nativeSelectClasses;
diff --git a/packages/material-ui/src/NativeSelect/nativeSelectClasses.js b/packages/material-ui/src/NativeSelect/nativeSelectClasses.js
new file mode 100644
index 00000000000000..70cfb0a4434ee9
--- /dev/null
+++ b/packages/material-ui/src/NativeSelect/nativeSelectClasses.js
@@ -0,0 +1,21 @@
+import { generateUtilityClass, generateUtilityClasses } from '@material-ui/unstyled';
+
+export function getNativeSelectUtilitiyClasses(slot) {
+  return generateUtilityClass('MuiNativeSelect', slot);
+}
+
+const nativeSelectClasses = generateUtilityClasses('MuiNativeSelect', [
+  'root',
+  'select',
+  'filled',
+  'outlined',
+  'selectMenu',
+  'disabled',
+  'icon',
+  'iconOpen',
+  'iconFilled',
+  'iconOutlined',
+  'nativeInput',
+]);
+
+export default nativeSelectClasses;