diff --git a/.circleci/config.yml b/.circleci/config.yml
index 8834341f39..191a1ba010 100644
--- a/.circleci/config.yml
+++ b/.circleci/config.yml
@@ -250,6 +250,12 @@ jobs:
             set -x
             brew bundle
             conan profile new default --detect
+
+            mkdir .cache
+            python3 -m venv .cache/venv
+            source .cache/venv/bin/activate
+            pip3 install --upgrade -r requirements.txt
+
           environment:
             HOMEBREW_NO_AUTO_UPDATE: 1
             CONAN_USER_HOME: '/Users/distiller/project/.cache'
diff --git a/.gitignore b/.gitignore
index f9266544f2..443d978ca7 100644
--- a/.gitignore
+++ b/.gitignore
@@ -30,3 +30,4 @@ paper/paper.pdf
 tmp
 build/
 *.bak
+Brewfile.lock.json
diff --git a/Brewfile b/Brewfile
index 5dd8544f30..dcba46c39c 100644
--- a/Brewfile
+++ b/Brewfile
@@ -2,7 +2,6 @@ brew "autoconf"
 brew "automake"
 brew "ccache"
 brew "cmake"
-brew "conan"
 brew "coreutils"
 brew "cppcheck"
 brew "ghr"
diff --git a/docs/dev/developers-guide-cli.md b/docs/dev/developers-guide-cli.md
index f2274766ae..961effd742 100644
--- a/docs/dev/developers-guide-cli.md
+++ b/docs/dev/developers-guide-cli.md
@@ -55,7 +55,7 @@ The easiest way to start the development is to use the included docker container
     💡 Quick install for macOS  (click to expand)
     </summary>
 
-    You need to install XCode command line tools. After that you can install remaining required dependencies using [Homebrew](https://brew.sh/) and pip
+    You need to install XCode command line tools. After that you can install remaining required dependencies using [Homebrew](https://brew.sh/) and pip (into a Python virtual environment)
 
     ```
     xcode-select --install
@@ -63,6 +63,11 @@ The easiest way to start the development is to use the included docker container
     cd nextclade
     brew bundle --file=Brewfile
 
+    mkdir .cache
+    python3 -m venv .cache/venv
+    source .cache/venv/bin/activate
+    pip3 install --upgrade -r requirements.txt
+
     ```
     </details>
     </p>