diff --git a/NEWS b/NEWS
index a94fef476a74c..54b3b252896e0 100644
--- a/NEWS
+++ b/NEWS
@@ -23,6 +23,9 @@ PHP                                                                        NEWS
   . Fixed bug GH-15432 (Heap corruption when querying a vector). (cmb,
     Kamil Tekiela)
 
+- PDO_MYSQL:
+  . mysqlnd: support ER_CLIENT_INTERACTION_TIMEOUT. (Appla)
+
 - Session:
   . Emit warnings for non-positive values of session.gc_divisor and negative values
     of session.gc_probability. (Jorg Sowa)
diff --git a/UPGRADING b/UPGRADING
index 48740ce43418e..610dee8b9e786 100644
--- a/UPGRADING
+++ b/UPGRADING
@@ -126,6 +126,10 @@ PHP 8.4 UPGRADE NOTES
     has changed. Consult https://github.com/PCRE2Project/pcre2/blob/master/NEWS
     for a full changelog.
 
+- MySQLnd
+  . The error code reported for MySQL server wait timeouts has been changed from 2006
+    to 4031 for MySQL server versions 8.0.24 and above.
+
 - PCNTL:
   . The functions pcntl_sigprocmask(), pcntl_sigwaitinfo() and
     pcntl_sigtimedwait() now throw:
diff --git a/ext/mysqli/tests/bug81335.phpt b/ext/mysqli/tests/bug81335.phpt
new file mode 100644
index 0000000000000..26f6bcd7e2d14
--- /dev/null
+++ b/ext/mysqli/tests/bug81335.phpt
@@ -0,0 +1,34 @@
+--TEST--
+Bug #81335: Packets out of order after connection timeout
+--EXTENSIONS--
+mysqli
+--SKIPIF--
+<?php
+if (PHP_OS === 'WINNT') die('skip on windows');
+if (getenv("SKIP_SLOW_TESTS")) die("skip slow test");
+
+require_once 'connect.inc';
+if (!$link = @my_mysqli_connect($host, $user, $passwd, $db, $port, $socket)) die("skip cannot connect");
+if (mysqli_get_server_version($link) < 80024 || str_contains(mysqli_get_server_info($link), 'MariaDB')) {
+    die("skip: Due to many MySQL Server differences, the test requires >= 8.0.24");
+}
+?>
+--FILE--
+<?php
+
+require_once 'connect.inc';
+mysqli_report(MYSQLI_REPORT_ERROR | MYSQLI_REPORT_STRICT);
+$mysqli = new my_mysqli($host, $user, $passwd, $db, $port, $socket);
+$mysqli->query('SET WAIT_TIMEOUT=1');
+usleep(1000000 * 1.1);
+try {
+    $mysqli->query('SELECT 1 + 1');
+} catch(mysqli_sql_exception $e) {
+    echo $e->getMessage();
+    echo "\n";
+    echo $e->getCode();
+}
+?>
+--EXPECTF--
+The client was disconnected by the server because of inactivity. See wait_timeout and interactive_timeout for configuring this behavior.
+4031
diff --git a/ext/mysqlnd/mysqlnd_enum_n_def.h b/ext/mysqlnd/mysqlnd_enum_n_def.h
index 15db002aa7349..5fe81b009febb 100644
--- a/ext/mysqlnd/mysqlnd_enum_n_def.h
+++ b/ext/mysqlnd/mysqlnd_enum_n_def.h
@@ -130,6 +130,7 @@
 #define CR_INVALID_PARAMETER_NO	2034
 #define CR_INVALID_BUFFER_USE	2035
 #define CR_LOAD_DATA_LOCAL_INFILE_REJECTED 2068
+#define CR_CLIENT_INTERACTION_TIMEOUT 4031
 
 #define MYSQLND_EE_FILENOTFOUND	 7890
 
diff --git a/ext/mysqlnd/mysqlnd_result.c b/ext/mysqlnd/mysqlnd_result.c
index 7f781d9e5cca7..ae8dc77b4cd9a 100644
--- a/ext/mysqlnd/mysqlnd_result.c
+++ b/ext/mysqlnd/mysqlnd_result.c
@@ -183,7 +183,7 @@ mysqlnd_query_read_result_set_header(MYSQLND_CONN_DATA * conn, MYSQLND_STMT * s)
 		UPSERT_STATUS_SET_AFFECTED_ROWS_TO_ERROR(conn->upsert_status);
 
 		if (FAIL == (ret = PACKET_READ(conn, &rset_header))) {
-			if (conn->error_info->error_no != CR_SERVER_GONE_ERROR) {
+			if (conn->error_info->error_no != CR_SERVER_GONE_ERROR && conn->error_info->error_no != CR_CLIENT_INTERACTION_TIMEOUT) {
 				php_error_docref(NULL, E_WARNING, "Error reading result set's header");
 			}
 			break;
diff --git a/ext/mysqlnd/mysqlnd_wireprotocol.c b/ext/mysqlnd/mysqlnd_wireprotocol.c
index 3b46fb2c985be..b1f38f01b2180 100644
--- a/ext/mysqlnd/mysqlnd_wireprotocol.c
+++ b/ext/mysqlnd/mysqlnd_wireprotocol.c
@@ -267,6 +267,19 @@ mysqlnd_read_header(MYSQLND_PFC * pfc, MYSQLND_VIO * vio, MYSQLND_PACKET_HEADER
 		pfc->data->packet_no++;
 		DBG_RETURN(PASS);
 	}
+	// @see https://dev.mysql.com/worklog/task/?id=12999
+	if (header->size > 0) {
+		zend_uchar *buf = mnd_emalloc(header->size);
+		if ((PASS == pfc->data->m.receive(pfc, vio, buf, header->size, conn_stats, error_info)) && buf[0] == ERROR_MARKER) {
+			php_mysqlnd_read_error_from_line(buf + 1, header->size - 1,
+			                                 error_info->error, sizeof(error_info->error),
+			                                 &error_info->error_no, error_info->sqlstate
+			);
+			mnd_efree(buf);
+			DBG_RETURN(FAIL);
+		}
+		mnd_efree(buf);
+	}
 
 	DBG_ERR_FMT("Logical link: packets out of order. Expected %u received %u. Packet size=%zu",
 				pfc->data->packet_no, header->packet_no, header->size);
@@ -294,7 +307,9 @@ mysqlnd_read_packet_header_and_body(MYSQLND_PACKET_HEADER * packet_header,
 	DBG_INF_FMT("buf=%p size=%zu", buf, buf_size);
 	if (FAIL == mysqlnd_read_header(pfc, vio, packet_header, stats, error_info)) {
 		SET_CONNECTION_STATE(connection_state, CONN_QUIT_SENT);
-		SET_CLIENT_ERROR(error_info, CR_SERVER_GONE_ERROR, UNKNOWN_SQLSTATE, mysqlnd_server_gone);
+		if (error_info->error_no == 0) {
+			SET_CLIENT_ERROR(error_info, CR_SERVER_GONE_ERROR, UNKNOWN_SQLSTATE, mysqlnd_server_gone);
+		}
 		DBG_ERR_FMT("Can't read %s's header", packet_type_as_text);
 		DBG_RETURN(FAIL);
 	}