diff --git a/compiler/rustc_codegen_llvm/src/coverageinfo/mod.rs b/compiler/rustc_codegen_llvm/src/coverageinfo/mod.rs
index 69babc7c9cf3e..c12eba5dfdd8c 100644
--- a/compiler/rustc_codegen_llvm/src/coverageinfo/mod.rs
+++ b/compiler/rustc_codegen_llvm/src/coverageinfo/mod.rs
@@ -9,6 +9,7 @@ use rustc_data_structures::fx::{FxHashMap, FxIndexMap};
 use rustc_llvm::RustString;
 use rustc_middle::bug;
 use rustc_middle::mir::coverage::CoverageKind;
+use rustc_middle::mir::{Statement, StatementKind};
 use rustc_middle::ty::layout::HasTyCtxt;
 use rustc_middle::ty::Instance;
 use rustc_target::abi::{Align, Size};
@@ -92,9 +93,8 @@ impl<'ll, 'tcx> CodegenCx<'ll, 'tcx> {
 
 impl<'tcx> CoverageInfoBuilderMethods<'tcx> for Builder<'_, '_, 'tcx> {
     fn init_coverage(&mut self, instance: Instance<'tcx>) {
-        let Some(function_coverage_info) =
-            self.tcx.instance_mir(instance.def).function_coverage_info.as_deref()
-        else {
+        let mir_body = self.tcx.instance_mir(instance.def);
+        let Some(function_coverage_info) = mir_body.function_coverage_info.as_deref() else {
             return;
         };
 
@@ -103,6 +103,22 @@ impl<'tcx> CoverageInfoBuilderMethods<'tcx> for Builder<'_, '_, 'tcx> {
             return;
         }
 
+        let is_mcdc_statement = |statement: &Statement<'_>| {
+            let StatementKind::Coverage(cov_kind) = &statement.kind else {
+                return false;
+            };
+            matches!(
+                cov_kind,
+                CoverageKind::TestVectorBitmapUpdate { .. } | CoverageKind::CondBitmapUpdate { .. }
+            )
+        };
+        // Some instances like `DropGlue` clone mir body from others and modified the basic blocks after coverage pass.
+        // Such instances might have same `function_coverage_info` as the primary but have no associated coverage statement.
+        // Ignore these instances here.
+        if !mir_body.basic_blocks.iter().map(|bb| &bb.statements).flatten().any(is_mcdc_statement) {
+            return;
+        }
+
         let fn_name = self.get_pgo_func_name_var(instance);
         let hash = self.const_u64(function_coverage_info.function_source_hash);
         let bitmap_bytes = self.const_u32(function_coverage_info.mcdc_bitmap_bytes);