diff --git a/compiler/rustc_mir_transform/src/known_panics_lint.rs b/compiler/rustc_mir_transform/src/known_panics_lint.rs
index a9cd688c31551..7cab665099482 100644
--- a/compiler/rustc_mir_transform/src/known_panics_lint.rs
+++ b/compiler/rustc_mir_transform/src/known_panics_lint.rs
@@ -585,20 +585,32 @@ impl<'mir, 'tcx> ConstPropagator<'mir, 'tcx> {
                 val.into()
             }
 
-            Aggregate(ref kind, ref fields) => Value::Aggregate {
-                fields: fields
-                    .iter()
-                    .map(|field| self.eval_operand(field).map_or(Value::Uninit, Value::Immediate))
-                    .collect(),
-                variant: match **kind {
-                    AggregateKind::Adt(_, variant, _, _, _) => variant,
-                    AggregateKind::Array(_)
-                    | AggregateKind::Tuple
-                    | AggregateKind::Closure(_, _)
-                    | AggregateKind::Coroutine(_, _)
-                    | AggregateKind::CoroutineClosure(_, _) => VariantIdx::new(0),
-                },
-            },
+            Aggregate(ref kind, ref fields) => {
+                // Do not const pop union fields as they can be
+                // made to produce values that don't match their
+                // underlying layout's type (see ICE #121534).
+                // If the last element of the `Adt` tuple
+                // is `Some` it indicates the ADT is a union
+                if let AggregateKind::Adt(_, _, _, _, Some(_)) = **kind {
+                    return None;
+                };
+                Value::Aggregate {
+                    fields: fields
+                        .iter()
+                        .map(|field| {
+                            self.eval_operand(field).map_or(Value::Uninit, Value::Immediate)
+                        })
+                        .collect(),
+                    variant: match **kind {
+                        AggregateKind::Adt(_, variant, _, _, _) => variant,
+                        AggregateKind::Array(_)
+                        | AggregateKind::Tuple
+                        | AggregateKind::Closure(_, _)
+                        | AggregateKind::Coroutine(_, _)
+                        | AggregateKind::CoroutineClosure(_, _) => VariantIdx::new(0),
+                    },
+                }
+            }
 
             Repeat(ref op, n) => {
                 trace!(?op, ?n);
diff --git a/tests/ui/lint/ice-unions-known-panics-lint-issue-121534.rs b/tests/ui/lint/ice-unions-known-panics-lint-issue-121534.rs
new file mode 100644
index 0000000000000..9fadb828b3d2d
--- /dev/null
+++ b/tests/ui/lint/ice-unions-known-panics-lint-issue-121534.rs
@@ -0,0 +1,21 @@
+// Regression test for #121534
+// Tests that no ICE occurs in KnownPanicsLint when it
+// evaluates an operation whose operands have different
+// layout types even though they have the same type.
+// This situation can be contrived through the use of
+// unions as in this test
+
+//@ build-pass
+union Union {
+    u32_field: u32,
+    i32_field: i32,
+}
+
+pub fn main() {
+    let u32_variant = Union { u32_field: 2 };
+    let i32_variant = Union { i32_field: 3 };
+    let a = unsafe { u32_variant.u32_field };
+    let b = unsafe { i32_variant.u32_field };
+
+    let _diff = a - b;
+}