XBB.1.5 sublineage with S:K462R and 2 ORF mutation (21 seqs- Peru, Japan and USA)

[HynnSpylor]

Defining mutations: XBB.1.5>G15649A (ORF1b:V728I), G22947A (S:K462R), C27925T (ORF8:T11I, but with the ORF8:G8* ahead), C835T, C4391A
GISAID query: Spike_K462R, C835T, C4391A ( Edited :or A22947G,C835T, C4391A)
Earliest seq: 2023-03-18 (Peru, EPI_ISL_17616713)
Most recent seq: 2023-04-18 (Japan, EPI_ISL_17631142)
Countries detected: Peru (11), USA (2), Japan (1)

Ushe Tree:

https://nextstrain.org/fetch/genome.ucsc.edu/trash/ct/subtreeAuspice1_genome_20296_d99d10.json
The S:K462R is quite rare (even all S:K462 mutations), with only about 110 high quality seqs. It emerged in some small branches of BA.1*, BA.2.38 and BA.2.76. Escape calculator shows the maximum potential in RBD region for XBB in site 462.

https://jbloomlab.github.io/SARS2_RBD_Ab_escape_maps/escape-calc/
Genomes:
EPI_ISL_17351703, EPI_ISL_17521421, EPI_ISL_17616713, EPI_ISL_17631142, EPI_ISL_17634855, EPI_ISL_17634870,
EPI_ISL_17634978, EPI_ISL_17634987, EPI_ISL_17635028, EPI_ISL_17635059-17635060, EPI_ISL_17635066, EPI_ISL_17639854,
EPI_ISL_17639868

[FedeGueli]

I would propose it in the main page. New potentisl interesting rbd mutation and geographical spread.

[HynnSpylor]

@FedeGueli I'm waiting for reaching 20 seqs (now 18seqs)

[FedeGueli]

@HynnSpylor now 21!! Lets go with a proposal!