diff --git a/apis/python/src/tiledbsoma/__init__.py b/apis/python/src/tiledbsoma/__init__.py
index 5c4ea7b031..4489fd9d73 100644
--- a/apis/python/src/tiledbsoma/__init__.py
+++ b/apis/python/src/tiledbsoma/__init__.py
@@ -6,7 +6,7 @@
 Python package is an implementation of SOMA using the
 `TileDB Embedded <https://github.com/TileDB-Inc/TileDB>`_ engine.
 
-Provides:
+Provides
 ----------
   1. The ability to store, query, and retrieve larger-than-core datasets,
      resident in both cloud (object-store) and local (file) systems.
@@ -17,7 +17,7 @@
 See the `SOMA GitHub repo <https://github.com/single-cell-data/SOMA>`_ for more
 information on the SOMA project.
 
-Using the documentation:
+Using the documentation
 -------------------------
 
 Documentation is also available via the Python builtin ``help`` function. We
@@ -26,7 +26,7 @@
 >>> import tiledbsoma
 >>> help(tiledbsoma.DataFrame)
 
-API maturity tags:
+API maturity tags
 ------------------
 
 Classes and functions are annotated with API maturity tags, for example:
@@ -49,7 +49,7 @@
 
 If no tag is present, the state is ``experimental``.
 
-Data types:
+Data types
 ------------
 
 The principal persistent types provided by SOMA are:
@@ -76,7 +76,7 @@
 example, the schema of a :class:`DataFrame` is expressed as an
 `Arrow Schema <https://arrow.apache.org/docs/python/generated/pyarrow.Schema.html>`_.
 
-Error handling:
+Error handling
 ---------------
 Most errors will be signaled with a raised Exception. Of note:
 
@@ -87,9 +87,6 @@
 
 Most errors will raise an appropriate Python error, e.g., ::class:`TypeError` or
 :class:`ValueError`.
-
-Classes and functions:
-----------------------
 """
 
 # ^^ the rest is autogen whether viewed from Python on-line help, Sphinx/readthedocs, etc.  It's
diff --git a/doc/source/conf.py b/doc/source/conf.py
index 5088cf6a4a..816da9cdd0 100644
--- a/doc/source/conf.py
+++ b/doc/source/conf.py
@@ -39,9 +39,12 @@
     "sphinx.ext.doctest",
     "sphinx.ext.intersphinx",
     "sphinx.ext.napoleon",
+    "sphinx.ext.autosummary",
     "nbsphinx",
 ]
 
+autosummary_generate = True
+
 # Mapping for linking between RTD subprojects.
 if readthedocs:
     intersphinx_mapping = {
diff --git a/doc/source/python-api.rst b/doc/source/python-api.rst
index 514c7d31e8..3a480a0feb 100644
--- a/doc/source/python-api.rst
+++ b/doc/source/python-api.rst
@@ -18,17 +18,10 @@ Features:
 * Enables out-of-core access to data aggregations much larger than single-host main memory
 * Enables distributed computation over datasets
 
-The tiledbsoma module
----------------------
-.. automodule:: tiledbsoma
-   :members:
-
-The tiledbsoma.io module
-------------------------
-.. automodule:: tiledbsoma.io
-   :members:
-
-The tiledbsoma.logging module
------------------------------
-.. automodule:: tiledbsoma.logging
-   :members:
+
+.. toctree:: 
+   :maxdepth: 2
+
+   python-tiledbsoma
+   python-tiledbsoma-io
+   python-tiledbsoma-logging
\ No newline at end of file
diff --git a/doc/source/python-tiledbsoma-io.rst b/doc/source/python-tiledbsoma-io.rst
new file mode 100644
index 0000000000..212ac1749f
--- /dev/null
+++ b/doc/source/python-tiledbsoma-io.rst
@@ -0,0 +1,22 @@
+The tiledbsoma.io module
+=====================
+
+.. currentmodule:: tiledbsoma.io
+
+.. automodule:: tiledbsoma.io
+
+
+Functions
+-------
+
+.. autosummary::
+    :toctree: _autosummary/
+    :nosignatures:
+
+    tiledbsoma.io.from_h5ad
+    tiledbsoma.io.from_anndata
+    tiledbsoma.io.add_X_layer
+    tiledbsoma.io.add_matrix_to_collection
+    tiledbsoma.io.create_from_matrix
+    tiledbsoma.io.to_h5ad
+    tiledbsoma.io.to_anndata
\ No newline at end of file
diff --git a/doc/source/python-tiledbsoma-logging.rst b/doc/source/python-tiledbsoma-logging.rst
new file mode 100644
index 0000000000..a00cb948fc
--- /dev/null
+++ b/doc/source/python-tiledbsoma-logging.rst
@@ -0,0 +1,18 @@
+The tiledbsoma.logging module
+=====================
+
+.. currentmodule:: tiledbsoma.logging
+
+.. automodule:: tiledbsoma.logging
+
+
+Functions
+-------
+
+.. autosummary::
+    :toctree: _autosummary/
+    :nosignatures:
+
+    tiledbsoma.logging.info
+    tiledbsoma.logging.debug
+    tiledbsoma.logging.warning
\ No newline at end of file
diff --git a/doc/source/python-tiledbsoma.rst b/doc/source/python-tiledbsoma.rst
new file mode 100644
index 0000000000..242ecef3e1
--- /dev/null
+++ b/doc/source/python-tiledbsoma.rst
@@ -0,0 +1,59 @@
+The tiledbsoma module
+=====================
+
+.. currentmodule:: tiledbsoma
+
+.. automodule:: tiledbsoma
+
+Classes
+-------
+
+.. autosummary::
+    :toctree: _autosummary/
+    :nosignatures:
+
+    tiledbsoma.Collection
+    tiledbsoma.Experiment
+    tiledbsoma.Measurement   
+
+    tiledbsoma.DataFrame
+    tiledbsoma.SparseNDArray
+    tiledbsoma.DenseNDArray
+
+      tiledbsoma.ResultOrder
+
+    tiledbsoma.AxisColumnNames
+    tiledbsoma.AxisQuery
+    tiledbsoma.ExperimentAxisQuery
+    
+    tiledbsoma.SOMATileDBContext
+
+Exceptions
+----------
+
+.. autosummary::
+    :toctree: _autosummary/
+    :nosignatures:
+
+    tiledbsoma.DoesNotExistError
+    tiledbsoma.SOMAError
+
+Functions
+---------
+
+.. autosummary::
+    :toctree: _autosummary/
+    :nosignatures:
+
+    tiledbsoma.open
+
+    tiledbsoma.show_package_versions
+
+    tiledbsoma.get_implementation
+    tiledbsoma.get_implementation_version
+    tiledbsoma.get_storage_engine
+
+    tiledbsoma.tiledbsoma_stats_disable
+    tiledbsoma.tiledbsoma_stats_dump
+    tiledbsoma.tiledbsoma_stats_enable
+    tiledbsoma.tiledbsoma_stats_reset
\ No newline at end of file