diff --git a/.flake8 b/.flake8
new file mode 100644
index 00000000..87ca071f
--- /dev/null
+++ b/.flake8
@@ -0,0 +1,8 @@
+# flake8 does not support pyproject.toml (https://github.com/PyCQA/flake8/issues/234)
+
+[flake8]
+select = F, W, E101, E111, E112, E113, E401, E402, E501, E711, E722
+# We should set max line length to 88 eventually
+max-line-length = 130
+exclude = .git,__pycache__,docs,build,dist,.tox,.eggs
+ignore = E203, W503, W504, W605
diff --git a/.github/workflows/ci.yml b/.github/workflows/ci.yml
index a59fd02b..5380e5ae 100644
--- a/.github/workflows/ci.yml
+++ b/.github/workflows/ci.yml
@@ -31,7 +31,7 @@ jobs:
         with:
           python-version: ${{ matrix.python-version }}
           cache: 'pip'
-          cache-dependency-path: setup.cfg
+          cache-dependency-path: 'pyproject.toml'
       - run: pip install "tox>=4.0"
       - run: tox -e ${{ matrix.toxenv }}
   test:
@@ -64,7 +64,7 @@ jobs:
         with:
           python-version: ${{ matrix.python-version }}
           cache: 'pip'
-          cache-dependency-path: setup.cfg
+          cache-dependency-path: 'pyproject.toml'
       - run: echo "CRDS_PATH=$HOME/crds_cache" >> $GITHUB_ENV
       - run: echo "CRDS_SERVER_URL=https://jwst-crds.stsci.edu" >> $GITHUB_ENV
       - run: pip install crds
diff --git a/docs/source/conf.py b/docs/source/conf.py
index ceb5cd6b..0018e851 100644
--- a/docs/source/conf.py
+++ b/docs/source/conf.py
@@ -6,6 +6,7 @@
 import importlib
 
 import stsci_rtd_theme
+import tomli
 
 
 def setup(app):
@@ -21,14 +22,11 @@ def setup(app):
 # in the path:
 sys.path.insert(0, str(REPO_ROOT/"src"/"stdatamodels"))
 
-# Read the package's setup.cfg so that we can use relevant
-# values here:
-conf = ConfigParser()
-conf.read(REPO_ROOT/"setup.cfg")
-setup_metadata = dict(conf.items("metadata"))
+with open(REPO_ROOT / "pyproject.toml", 'rb') as configuration_file:
+    setup_metadata = tomli.load(configuration_file)['project']
 
 project = setup_metadata["name"]
-author = setup_metadata["author"]
+author = setup_metadata["authors"][0]["name"]
 copyright = f"{datetime.now().year}, {author}"
 
 package = importlib.import_module(setup_metadata["name"])
diff --git a/pyproject.toml b/pyproject.toml
index 560ba074..0e08a614 100644
--- a/pyproject.toml
+++ b/pyproject.toml
@@ -1,6 +1,149 @@
+[project]
+name = "stdatamodels"
+description = "Core support for DataModel classes used in calibration pipelines"
+requires-python = ">=3.6"
+authors = [
+    { name = "STScI" },
+]
+classifiers = [
+    "Intended Audience :: Science/Research",
+    "Topic :: Scientific/Engineering :: Astronomy",
+    "License :: OSI Approved :: BSD License",
+    "Programming Language :: Python :: 3",
+]
+dependencies = [
+    "jsonschema>=3.0.2",
+    "asdf>=2.14.1",
+    "asdf-astropy>=0.3.0",
+    "psutil>=5.7.2",
+    "numpy>=1.16",
+    "astropy>=5.0.4",
+    "stcal>=1.3.2,<1.4",
+]
+dynamic = [
+    "version",
+]
+
+[project.readme]
+file = "README.md"
+content-type = "text/markdown"
+
+[project.license]
+file = "LICENSE"
+content-type = "text/plain"
+
+[project.urls]
+Homepage = "https://github.com/spacetelescope/stdatamodels"
+"Bug Tracker" = "https://github.com/spacetelescope/stdatamodels/issues"
+"Source Code" = "https://github.com/spacetelescope/stdatamodels"
+
+[project.entry-points."asdf.extensions"]
+jwst_pipeline = "stdatamodels.jwst.transforms.integration:get_extensions"
+
+[project.entry-points."asdf.resource_mappings"]
+jwst_datamodel = "stdatamodels.jwst.datamodels.integration:get_resource_mappings"
+jwst_pipeline = "stdatamodels.jwst.transforms.integration:get_resource_mappings"
+
+[project.optional-dependencies]
+test = [
+    "asdf>=2.8.0",
+    "psutil",
+    "pytest>=4.6.0",
+    "pytest-doctestplus",
+    "pytest-openfiles>=0.5.0",
+    "crds>=11.16.14",
+]
+docs = [
+    "sphinx",
+    "sphinx-automodapi",
+    "numpydoc",
+    "sphinx-rtd-theme",
+    "stsci-rtd-theme",
+    "sphinx-asdf>=0.1.1",
+]
+aws = [
+    "stsci-aws-utils>=0.1.2",
+]
+
 [build-system]
-requires = ["setuptools>=42", "setuptools_scm[toml]>=3.4", "wheel"]
+requires = [
+    "setuptools>=61.2",
+    "setuptools_scm[toml]>=3.4",
+    "wheel",
+]
 build-backend = "setuptools.build_meta"
 
+[tool.setuptools]
+zip-safe = true
+include-package-data = false
+
+[tool.setuptools.packages.find]
+where = [
+    "src",
+]
+namespaces = false
+
+[tool.setuptools.package-dir]
+"" = "src"
+
+[tool.setuptools.package-data]
+"*" = [
+    "*.yaml",
+]
+"stdatamodels.jwst.transforms" = [
+    "resources/schemas/stsci.edu/jwst_pipeline/*.yaml",
+]
+
+[tool.flake8]
+exclude = [
+    ".git",
+    "__pycache__",
+    "docs",
+    "build",
+    "dist",
+    ".tox",
+    ".eggs",
+]
+ignore = [
+    "E203",
+    "W503",
+    "W504",
+    "W605",
+]
+max-line-length = 130
+select = [
+    "F",
+    "W",
+    "E101",
+    "E111",
+    "E112",
+    "E113",
+    "E401",
+    "E402",
+    "E501",
+    "E711",
+    "E722",
+]
+
+[tool.pytest.ini_options]
+minversion = "4.6"
+doctest_plus = true
+doctest_rst = true
+text_file_format = "rst"
+addopts = "--open-files"
+testpaths = [
+    "tests",
+    "src/stdatamodels/jwst",
+]
+asdf_schema_tests_enabled = true
+asdf_schema_validate_default = false
+asdf_schema_root = "src/stdatamodels/jwst/datamodels/schemas\nsrc/stdatamodels/jwst/transforms/resources/schemas"
+norecursedirs = [
+    "build",
+    ".tox",
+    ".eggs",
+    "venv",
+]
+
 [tool.setuptools_scm]
 write_to = "src/stdatamodels/_version.py"
diff --git a/setup.cfg b/setup.cfg
deleted file mode 100644
index 9f08b64e..00000000
--- a/setup.cfg
+++ /dev/null
@@ -1,88 +0,0 @@
-[metadata]
-name = stdatamodels
-description = Core support for DataModel classes used in calibration pipelines
-long_description = Core support for DataModel classes used in calibration pipelines
-long_description_content_type = text/markdown
-author = STScI
-license = BSD-3-Clause
-url = https://github.com/spacetelescope/stdatamodels
-project_urls =
-    Bug Tracker = https://github.com/spacetelescope/stdatamodels/issues
-    Source Code = https://github.com/spacetelescope/stdatamodels
-classifiers =
-    Intended Audience :: Science/Research
-    Topic :: Scientific/Engineering :: Astronomy
-    License :: OSI Approved :: BSD License
-    Programming Language :: Python :: 3
-
-[options]
-zip_safe = True
-python_requires = >=3.6
-setup_requires =
-    setuptools_scm
-install_requires =
-    jsonschema>=3.0.2
-    asdf>=2.14.1
-    asdf-astropy>=0.3.0
-    psutil>=5.7.2
-    numpy>=1.16
-    astropy>=5.0.4
-    stcal>=1.3.2,<1.4
-package_dir =
-    =src
-packages = find:
-
-[options.packages.find]
-where = src
-
-[options.extras_require]
-test =
-    asdf>=2.8.0
-    psutil
-    pytest>=4.6.0
-    pytest-doctestplus
-    pytest-openfiles>=0.5.0
-    crds>=11.16.14
-docs =
-    sphinx
-    sphinx-automodapi
-    numpydoc
-    sphinx-rtd-theme
-    stsci-rtd-theme
-    sphinx-asdf>=0.1.1
-aws =
-    stsci-aws-utils>=0.1.2
-
-[flake8]
-select = F, W, E101, E111, E112, E113, E401, E402, E501, E711, E722
-# We should set max line length to 88 eventually
-max-line-length = 130
-exclude = .git,__pycache__,docs,build,dist,.tox,.eggs
-ignore = E203, W503, W504, W605
-
-[tool:pytest]
-minversion = 4.6
-doctest_plus = true
-doctest_rst = true
-text_file_format = rst
-addopts = --open-files
-testpaths =
-    tests
-    src/stdatamodels/jwst
-asdf_schema_tests_enabled = true
-asdf_schema_validate_default = false
-asdf_schema_root =
-    src/stdatamodels/jwst/datamodels/schemas
-    src/stdatamodels/jwst/transforms/resources/schemas
-norecursedirs =
-    build
-    .tox
-    .eggs
-    venv
-
-[options.entry_points]
-asdf.extensions =
-    jwst_pipeline = stdatamodels.jwst.transforms.integration:get_extensions
-asdf.resource_mappings =
-    jwst_datamodel = stdatamodels.jwst.datamodels.integration:get_resource_mappings
-    jwst_pipeline = stdatamodels.jwst.transforms.integration:get_resource_mappings
diff --git a/setup.py b/setup.py
deleted file mode 100644
index 35b81509..00000000
--- a/setup.py
+++ /dev/null
@@ -1,17 +0,0 @@
-#!/usr/bin/env python3
-from setuptools import setup
-
-package_data = {
-    "": [
-        "*.yaml",
-    ],
-    # Include the transforms schemas
-    "stdatamodels.jwst.transforms": [
-        "resources/schemas/stsci.edu/jwst_pipeline/*.yaml",
-    ],
-}
-
-setup(
-    use_scm_version={"write_to": "src/stdatamodels/_version.py"},
-    package_data=package_data,
-)
diff --git a/tox.ini b/tox.ini
index 20c7d8a1..c2f7246c 100644
--- a/tox.ini
+++ b/tox.ini
@@ -57,7 +57,7 @@ commands_pre =
 commands =
     pytest \
     xdist: -n auto \
-    cov: --cov=. --cov-config=setup.cfg --cov-report=term-missing --cov-report=xml \
+    cov: --cov=. --cov-config=pyproject.toml --cov-report=term-missing --cov-report=xml \
     jwst: --pyargs jwst --ignore-glob=*/scripts/* \
     # TODO: fix bug with `.finalize()` in `jwst.associations`
     jwst: --ignore-glob=*/associations/tests/test_dms.py \