diff --git a/CHANGELOG.md b/CHANGELOG.md
index dae1300c42..5654d7ebae 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -23,7 +23,7 @@ We use *breaking :warning:* to mark changes that are not backward compatible (re
 
 ### Changed
 
-- 
+- [#4354](https://github.com/thanos-io/thanos/pull/4354) Receive: use the S2 library for decoding Snappy data; saves about 5-7% of CPU time in the Receive component when handling incoming remote write requests
 
 ## [v0.21.1](https://github.com/thanos-io/thanos/releases/tag/v0.21.1) - 2021.06.04
 
diff --git a/go.mod b/go.mod
index b453556881..1e7f69f73d 100644
--- a/go.mod
+++ b/go.mod
@@ -33,6 +33,7 @@ require (
 	github.com/grpc-ecosystem/go-grpc-prometheus v1.2.0
 	github.com/hashicorp/golang-lru v0.5.4
 	github.com/jpillora/backoff v1.0.0
+	github.com/klauspost/compress v1.13.1
 	github.com/leanovate/gopter v0.2.4
 	github.com/lightstep/lightstep-tracer-go v0.18.1
 	github.com/lovoo/gcloud-opentracing v0.3.0
diff --git a/go.sum b/go.sum
index 24fec065f0..2a5a9fd22b 100644
--- a/go.sum
+++ b/go.sum
@@ -819,6 +819,8 @@ github.com/kisielk/errcheck v1.5.0/go.mod h1:pFxgyoBC7bSaBwPgfKdkLd5X25qrDl4LWUI
 github.com/kisielk/gotool v1.0.0/go.mod h1:XhKaO+MFFWcvkIS/tQcRk01m1F5IRFswLeQ+oQHNcck=
 github.com/klauspost/compress v1.4.0/go.mod h1:RyIbtBH6LamlWaDj8nUwkbUhJ87Yi3uG0guNDohfE1A=
 github.com/klauspost/compress v1.9.5/go.mod h1:RyIbtBH6LamlWaDj8nUwkbUhJ87Yi3uG0guNDohfE1A=
+github.com/klauspost/compress v1.13.1 h1:wXr2uRxZTJXHLly6qhJabee5JqIhTRoLBhDOA74hDEQ=
+github.com/klauspost/compress v1.13.1/go.mod h1:8dP1Hq4DHOhN9w426knH3Rhby4rFm6D8eO+e+Dq5Gzg=
 github.com/klauspost/cpuid v0.0.0-20170728055534-ae7887de9fa5/go.mod h1:Pj4uuM528wm8OyEC2QMXAi2YiTZ96dNQPGgoMS4s3ek=
 github.com/klauspost/cpuid v1.2.3/go.mod h1:Pj4uuM528wm8OyEC2QMXAi2YiTZ96dNQPGgoMS4s3ek=
 github.com/klauspost/cpuid v1.3.1 h1:5JNjFYYQrZeKRJ0734q51WCEEn2huer72Dc7K+R/b6s=
diff --git a/pkg/receive/handler.go b/pkg/receive/handler.go
index cbe0601f2b..178cd0b969 100644
--- a/pkg/receive/handler.go
+++ b/pkg/receive/handler.go
@@ -20,8 +20,8 @@ import (
 	"github.com/go-kit/kit/log"
 	"github.com/go-kit/kit/log/level"
 	"github.com/gogo/protobuf/proto"
-	"github.com/golang/snappy"
 	"github.com/jpillora/backoff"
+	"github.com/klauspost/compress/s2"
 	"github.com/mwitkow/go-conntrack"
 	"github.com/opentracing/opentracing-go"
 	"github.com/pkg/errors"
@@ -295,7 +295,7 @@ func (h *Handler) receiveHTTP(w http.ResponseWriter, r *http.Request) {
 		return
 	}
 
-	reqBuf, err := snappy.Decode(nil, compressed.Bytes())
+	reqBuf, err := s2.Decode(nil, compressed.Bytes())
 	if err != nil {
 		level.Error(h.logger).Log("msg", "snappy decode error", "err", err)
 		http.Error(w, errors.Wrap(err, "snappy decode error").Error(), http.StatusBadRequest)