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figure4_test.html
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<!DOCTYPE html>
<html>
<head>
<meta charset="UTF-8"/>
<meta http-equiv="X-UA-Compatible" content="IE=edge"/>
<title>Juicebox</title>
<meta name="viewport" content="width=device-width, initial-scale=1.0"/>
<link rel="icon" type="image/png" href="https://aidenlab.org/favicon.ico">
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href="https://cdn.datatables.net/v/dt/dt-1.10.15/sc-1.4.2/se-1.2.2/datatables.min.css"/>
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</head>
<body style="margin:30px">
<h1 style="text-align: center; font:Helvetica Neue;font-size:36px;line-height: 40px; color: #333333
">Figure 4</h1>
<div class="row">
<div class="col-md-12">
<div>
<p style="font-size:30px" class="panelID">A</p>
</div>
</div>
</div>
<div class="row">
<div class="col-md-1">
<div>
<img class="img-responsive"
src="https://theaidenlab.github.io/figures/css/img/figure4_static_components/4A_untreated_header.png"
alt="Untreated" width="100">
</div>
<br>
</div>
<div class="col-md-2">
<div id="app-container-1">
</div>
<br>
</div>
<div class="col-md-2">
<div id="app-container-3">
</div>
<br>
</div>
<div class="col-md-3">
<div id="app-container-5">
</div>
<br>
</div>
<div class="col-md-4">
<div id="app-container-7">
</div>
<br>
</div>
</div>
<div class="row">
<div class="col-md-1">
<div>
<img class="img-responsive"
src="https://theaidenlab.github.io/figures/css/img/figure4_static_components/4A_treated_header.png"
alt="6hr Auxin treated" width="100">
</div>
<br>
</div>
<div class="col-md-2">
<div id="app-container-2">
</div>
<br>
</div>
<div class="col-md-2">
<div id="app-container-4">
</div>
<br>
</div>
<div class="col-md-3">
<div id="app-container-6">
</div>
<br>
</div>
<div class="col-md-4">
<div id="app-container-8">
</div>
<br>
</div>
</div>
<div class="row">
<div class="col-md-4">
<div>
<p style="font-size:30px" class="panelID">B</p>
</div>
<br>
<div>
<img src="https://theaidenlab.github.io/figures/css/img/figure4_static_components/4B_loop_lengths.png"
alt="loop lengths" width="300">
</div>
<br>
</div>
<div class="col-md-8">
<div>
<p style="font-size:30px" class="panelID">D</p>
</div>
<br>
<div>
<img src="https://theaidenlab.github.io/figures/css/img/figure4_static_components/4D_SE_enrichment.png"
alt="SE enrichments" width="600">
</div>
<br>
</div>
</div>
<div class="row">
<div class="col-md-4">
<div>
<p style="font-size:30px" class="panelID">C</p>
</div>
<br>
<div>
<img src="https://theaidenlab.github.io/figures/css/img/figure4_static_components/4C_CTCF_orientations.png"
alt="CTCF_orientations" width="300">
</div>
<br>
</div>
<div class="col-md-8">
<div>
<p style="font-size:30px" class="panelID">E</p>
</div>
<br>
<div>
<img src="https://theaidenlab.github.io/figures/css/img/figure4_static_components/4E_timecourse_APA.png"
alt="timecourse APA" width="600">
</div>
<br>
</div>
</div>
<br>
<div>
<p class="legend">(A) Examples of a network of intra- and interchromosomal cohesin-independent links between
superenhancers on chr6, chr4, and chr2. H3K27 acetylation does not change with auxin treatment, but
cohesin-independent links are significantly strengthened upon treatment. Intrachromosomal matrices are shown at
25kb (on-diagonal) and 50kb (off-diagonal) resolutions; interchromosomal matrices are shown at 100kb resolution.
Maximum color intensities are 28 reads for the offdiagonal intrachromosomal matrices and 20 reads for the
interchromosomal matrices.</p>
</div>
<div>
<p class="legend">(B) Length distribution of cohesin-mediated loops (green) versus cohesin-independent loops
(blue). </p>
</div>
<div>
<p class="legend">(C) CTCF binding patterns at cohesin-associated (top) versus cohesin-independent loop anchors
(bottom). Only cohesin-associated loops obey the convergent rule. </p>
</div>
<div>
<p class="legend">(D) Percent of cohesin-independent loop anchors bound versus fold enrichment for 36 DNA-binding
proteins and histone modifications. Superenhancers are strongly enriched at cohesin-independent loop
anchors.</p>
</div>
<div>
<p class="legend">(E) APA for intrachromosomal (blue) and interchromosomal (red) cohesin-independent links across a
time course of auxin treatment and withdrawal. APA scores are shown on top and APA plots for each time point are
shown on the bottom. Cohesin-independent links are rapidly strengthened as cohesin is degraded and weaken as
cohesin is restored.</p>
</div>
<style type="text/css">
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display: flex;
}
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text-align: left;
font: Helvetica Neue;
font-size: 36;
px color: #333333;
}
.col-md-2 {
display: inline-flex;
flex-direction: column;
justify-content: center;
}
</style>
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