diff --git a/server/grpc_service.go b/server/grpc_service.go
index 8dee8cc9f464..c4c79fb025aa 100644
--- a/server/grpc_service.go
+++ b/server/grpc_service.go
@@ -68,6 +68,7 @@ var (
 	ErrForwardTSOTimeout                = status.Errorf(codes.DeadlineExceeded, "forward tso request timeout")
 	ErrMaxCountTSOProxyRoutinesExceeded = status.Errorf(codes.ResourceExhausted, "max count of concurrent tso proxy routines exceeded")
 	ErrTSOProxyRecvFromClientTimeout    = status.Errorf(codes.DeadlineExceeded, "tso proxy timeout when receiving from client; stream closed by server")
+	ErrEtcdClientRequestFailed          = status.Errorf(codes.Internal, "etcd client request failed")
 )
 
 // GrpcServer wraps Server to provide grpc service.
@@ -275,7 +276,7 @@ func (s *GrpcServer) getMinTSFromSingleServer(
 }
 
 // GetMembers implements gRPC PDServer.
-func (s *GrpcServer) GetMembers(context.Context, *pdpb.GetMembersRequest) (*pdpb.GetMembersResponse, error) {
+func (s *GrpcServer) GetMembers(ctx context.Context, _ *pdpb.GetMembersRequest) (*pdpb.GetMembersResponse, error) {
 	// Here we purposely do not check the cluster ID because the client does not know the correct cluster ID
 	// at startup and needs to get the cluster ID with the first request (i.e. GetMembers).
 	if s.IsClosed() {
@@ -283,7 +284,7 @@ func (s *GrpcServer) GetMembers(context.Context, *pdpb.GetMembersRequest) (*pdpb
 			Header: s.wrapErrorToHeader(pdpb.ErrorType_UNKNOWN, errs.ErrServerNotStarted.FastGenByArgs().Error()),
 		}, nil
 	}
-	members, err := cluster.GetMembers(s.GetClient())
+	members, err := cluster.GetMembers(s.GetEtcdClientWithRetry(ctx))
 	if err != nil {
 		return &pdpb.GetMembersResponse{
 			Header: s.wrapErrorToHeader(pdpb.ErrorType_UNKNOWN, err.Error()),
@@ -2281,9 +2282,9 @@ const globalConfigPath = "/global/config/"
 // StoreGlobalConfig store global config into etcd by transaction
 // Since item value needs to support marshal of different struct types,
 // it should be set to `Payload bytes` instead of `Value string`
-func (s *GrpcServer) StoreGlobalConfig(_ context.Context, request *pdpb.StoreGlobalConfigRequest) (*pdpb.StoreGlobalConfigResponse, error) {
-	if s.client == nil {
-		return nil, errors.New("failed to store global config, etcd client not found")
+func (s *GrpcServer) StoreGlobalConfig(ctx context.Context, request *pdpb.StoreGlobalConfigRequest) (*pdpb.StoreGlobalConfigResponse, error) {
+	if s.GetEtcdClientWithRetry(ctx) == nil {
+		return &pdpb.StoreGlobalConfigResponse{}, ErrEtcdClientRequestFailed
 	}
 	configPath := request.GetConfigPath()
 	if configPath == "" {
@@ -2319,8 +2320,8 @@ func (s *GrpcServer) StoreGlobalConfig(_ context.Context, request *pdpb.StoreGlo
 // - `Names` iteratively get value from `ConfigPath/Name` but not care about revision
 // - `ConfigPath` if `Names` is nil can get all values and revision of current path
 func (s *GrpcServer) LoadGlobalConfig(ctx context.Context, request *pdpb.LoadGlobalConfigRequest) (*pdpb.LoadGlobalConfigResponse, error) {
-	if s.client == nil {
-		return nil, errors.New("failed to load global config, etcd client not found")
+	if s.GetEtcdClientWithRetry(ctx) == nil {
+		return &pdpb.LoadGlobalConfigResponse{}, ErrEtcdClientRequestFailed
 	}
 	configPath := request.GetConfigPath()
 	if configPath == "" {
@@ -2358,11 +2359,12 @@ func (s *GrpcServer) LoadGlobalConfig(ctx context.Context, request *pdpb.LoadGlo
 // by Etcd.Watch() as long as the context has not been canceled or timed out.
 // Watch on revision which greater than or equal to the required revision.
 func (s *GrpcServer) WatchGlobalConfig(req *pdpb.WatchGlobalConfigRequest, server pdpb.PD_WatchGlobalConfigServer) error {
-	if s.client == nil {
-		return errors.Errorf("failed to watch global config, etcd client not found")
-	}
 	ctx, cancel := context.WithCancel(s.Context())
 	defer cancel()
+	if s.GetEtcdClientWithRetry(ctx) == nil {
+		return ErrEtcdClientRequestFailed
+	}
+	println("WatchGlobalConfig")
 	configPath := req.GetConfigPath()
 	if configPath == "" {
 		configPath = globalConfigPath
diff --git a/server/server.go b/server/server.go
index 5bf26f3c58d7..5274b80bcba4 100644
--- a/server/server.go
+++ b/server/server.go
@@ -786,6 +786,22 @@ func (s *Server) GetClient() *clientv3.Client {
 	return s.client
 }
 
+func (s *Server) GetEtcdClientWithRetry(ctx context.Context) *clientv3.Client {
+	newCtx, cancel := context.WithTimeout(ctx, EtcdStartTimeout)
+	defer cancel()
+
+	ticker := time.NewTicker(retryIntervalGetServicePrimary)
+	defer ticker.Stop()
+	for s.client == nil {
+		select {
+		case <-newCtx.Done(): // timeout
+			return nil
+		case <-ticker.C:
+		}
+	}
+	return s.client
+}
+
 // GetHTTPClient returns builtin http client.
 func (s *Server) GetHTTPClient() *http.Client {
 	return s.httpClient
diff --git a/tests/integrations/client/global_config_test.go b/tests/integrations/client/global_config_test.go
index 15034d035a69..cf00d34f0d73 100644
--- a/tests/integrations/client/global_config_test.go
+++ b/tests/integrations/client/global_config_test.go
@@ -335,20 +335,28 @@ func (suite *globalConfigTestSuite) TestEtcdNotStart() {
 	suite.mu.Lock()
 	suite.server.SetClient(nil)
 	suite.mu.Unlock()
-	err := suite.server.WatchGlobalConfig(&pdpb.WatchGlobalConfigRequest{
+
+	go func() {
+		time.Sleep(100 * time.Millisecond)
+		suite.mu.Lock()
+		suite.server.SetClient(cli)
+		suite.mu.Unlock()
+	}()
+
+	server := testReceiver{re: suite.Require()}
+	go suite.server.WatchGlobalConfig(&pdpb.WatchGlobalConfigRequest{
 		ConfigPath: globalConfigPath,
 		Revision:   0,
-	}, nil)
-	suite.Error(err)
+	}, server)
 
-	_, err = suite.server.StoreGlobalConfig(suite.server.Context(), &pdpb.StoreGlobalConfigRequest{
+	_, err := suite.server.StoreGlobalConfig(suite.server.Context(), &pdpb.StoreGlobalConfigRequest{
 		ConfigPath: globalConfigPath,
 		Changes:    []*pdpb.GlobalConfigItem{{Kind: pdpb.EventType_PUT, Name: "0", Payload: []byte("0")}},
 	})
-	suite.Error(err)
+	suite.NoError(err)
 
 	_, err = suite.server.LoadGlobalConfig(suite.server.Context(), &pdpb.LoadGlobalConfigRequest{
 		Names: []string{"test_etcd"},
 	})
-	suite.Error(err)
+	suite.NoError(err)
 }