diff --git a/.changeset/neat-donuts-enjoy.md b/.changeset/neat-donuts-enjoy.md
new file mode 100644
index 0000000000..4d922e859d
--- /dev/null
+++ b/.changeset/neat-donuts-enjoy.md
@@ -0,0 +1,6 @@
+---
+'@twilio-paste/combobox': patch
+'@twilio-paste/core': patch
+---
+
+[Combobox] prevent selection of disabled items when using keyboard navigation and the enter key
diff --git a/.changeset/thin-kids-beam.md b/.changeset/thin-kids-beam.md
new file mode 100644
index 0000000000..085d0d8ae9
--- /dev/null
+++ b/.changeset/thin-kids-beam.md
@@ -0,0 +1,6 @@
+---
+'@twilio-paste/combobox-primitive': patch
+'@twilio-paste/core': patch
+---
+
+[Combobox Primitive] export new type `UseComboboxPrimitiveStateChangeOptions` to help type stateReducers
diff --git a/packages/paste-core/components/combobox/src/singleselect/Combobox.tsx b/packages/paste-core/components/combobox/src/singleselect/Combobox.tsx
index cdc92a0e5e..9bed439c55 100644
--- a/packages/paste-core/components/combobox/src/singleselect/Combobox.tsx
+++ b/packages/paste-core/components/combobox/src/singleselect/Combobox.tsx
@@ -100,6 +100,7 @@ const Combobox = React.forwardRef<HTMLInputElement, ComboboxProps>(
       state,
       getA11yStatusMessage,
       getA11ySelectionMessage,
+      disabledItems,
     });
 
     if (
diff --git a/packages/paste-core/components/combobox/src/singleselect/extractPropsFromState.tsx b/packages/paste-core/components/combobox/src/singleselect/extractPropsFromState.tsx
index 1962f5099e..669a47f6c0 100644
--- a/packages/paste-core/components/combobox/src/singleselect/extractPropsFromState.tsx
+++ b/packages/paste-core/components/combobox/src/singleselect/extractPropsFromState.tsx
@@ -1,6 +1,11 @@
 import * as React from 'react';
 import {useComboboxPrimitive} from '@twilio-paste/combobox-primitive';
-import type {UseComboboxPrimitiveStateChange, UseComboboxPrimitiveReturnValue} from '@twilio-paste/combobox-primitive';
+import type {
+  UseComboboxPrimitiveState,
+  UseComboboxPrimitiveStateChange,
+  UseComboboxPrimitiveStateChangeOptions,
+  UseComboboxPrimitiveReturnValue,
+} from '@twilio-paste/combobox-primitive';
 import isEmpty from 'lodash/isEmpty';
 
 import type {ComboboxProps} from '../types';
@@ -16,6 +21,7 @@ type DefaultStateProps = {
   selectedItem: ComboboxProps['selectedItem'];
   initialSelectedItem: ComboboxProps['initialSelectedItem'];
   items: ComboboxProps['items'];
+  disabledItems: ComboboxProps['disabledItems'];
   getA11yStatusMessage: ComboboxProps['getA11yStatusMessage'];
   getA11ySelectionMessage: ComboboxProps['getA11ySelectionMessage'];
 };
@@ -33,10 +39,24 @@ const getDefaultState = ({
   items,
   getA11yStatusMessage,
   getA11ySelectionMessage,
+  disabledItems,
 }: DefaultStateProps): Partial<UseComboboxPrimitiveReturnValue<any>> => {
+  const stateReducer = (
+    state: UseComboboxPrimitiveState<any>,
+    actionAndChanges: UseComboboxPrimitiveStateChangeOptions<any>
+  ): Partial<UseComboboxPrimitiveState<any>> => {
+    // If the item to be selected is disabled, return the current state without changes
+    if (disabledItems?.includes(actionAndChanges.changes.selectedItem)) {
+      return state;
+    }
+
+    return actionAndChanges.changes;
+  };
+
   return useComboboxPrimitive({
     initialSelectedItem,
     items,
+    stateReducer,
     onHighlightedIndexChange: React.useCallback(
       (changes: UseComboboxPrimitiveStateChange<string>) => {
         if (onHighlightedIndexChange) {
diff --git a/packages/paste-core/components/combobox/stories/Combobox.stories.tsx b/packages/paste-core/components/combobox/stories/Combobox.stories.tsx
index c5fe7a6a1d..0024e41531 100644
--- a/packages/paste-core/components/combobox/stories/Combobox.stories.tsx
+++ b/packages/paste-core/components/combobox/stories/Combobox.stories.tsx
@@ -484,6 +484,7 @@ export const ComboboxObject: StoryFn = () => {
         }
       }}
       itemToString={(item: ObjectItem) => (item ? item.label : '')}
+      disabledItems={objectItems.slice(2, 5)}
     />
   );
 };
diff --git a/packages/paste-core/primitives/combobox/src/index.tsx b/packages/paste-core/primitives/combobox/src/index.tsx
index a41e6d9d94..9da36c54b6 100644
--- a/packages/paste-core/primitives/combobox/src/index.tsx
+++ b/packages/paste-core/primitives/combobox/src/index.tsx
@@ -13,6 +13,7 @@ export type {
   UseComboboxState as UseComboboxPrimitiveState,
   UseComboboxReturnValue as UseComboboxPrimitiveReturnValue,
   UseComboboxStateChange as UseComboboxPrimitiveStateChange,
+  UseComboboxStateChangeOptions as UseComboboxPrimitiveStateChangeOptions,
   UseComboboxGetItemPropsOptions as UseComboboxPrimitiveGetItemPropsOptions,
   UseComboboxGetMenuPropsOptions as UseComboboxPrimitiveGetMenuPropsOptions,
   GetPropsCommonOptions as GetComboboxPrimitivePropsCommonOptions,