diff --git a/packages/grid/src/vaadin-grid-keyboard-navigation-mixin.js b/packages/grid/src/vaadin-grid-keyboard-navigation-mixin.js
index 8dfbd33792..101f84d051 100644
--- a/packages/grid/src/vaadin-grid-keyboard-navigation-mixin.js
+++ b/packages/grid/src/vaadin-grid-keyboard-navigation-mixin.js
@@ -814,10 +814,12 @@ export const KeyboardNavigationMixin = (superClass) =>
       const rootTarget = e.composedPath()[0];
 
       if (rootTarget === this.$.table || rootTarget === this.$.focusexit) {
-        // The focus enters the top (bottom) of the grid, meaning that user has
-        // tabbed (shift-tabbed) into the grid. Move the focus to
-        // the first (the last) focusable.
-        this._predictFocusStepTarget(rootTarget, rootTarget === this.$.table ? 1 : -1).focus();
+        if (!this._isMousedown) {
+          // The focus enters the top (bottom) of the grid, meaning that user has
+          // tabbed (shift-tabbed) into the grid. Move the focus to
+          // the first (the last) focusable.
+          this._predictFocusStepTarget(rootTarget, rootTarget === this.$.table ? 1 : -1).focus();
+        }
         this._setInteracting(false);
       } else {
         this._detectInteracting(e);
diff --git a/packages/grid/test/keyboard-navigation.common.js b/packages/grid/test/keyboard-navigation.common.js
index 9fb368e175..03acc577a5 100644
--- a/packages/grid/test/keyboard-navigation.common.js
+++ b/packages/grid/test/keyboard-navigation.common.js
@@ -544,6 +544,17 @@ describe('keyboard navigation', () => {
       expect(grid.shadowRoot.activeElement).to.equal(tabbableElements[3]);
     });
 
+    it('should not enter grid on table click', () => {
+      const tabbableElements = getTabbableElements(grid.shadowRoot);
+
+      // Click and focusin on table element
+      mouseDown(tabbableElements[0]);
+      focusin(tabbableElements[0], focusable);
+
+      // Expect no focus on header cell
+      expect(grid.shadowRoot.activeElement).to.be.null;
+    });
+
     it('should set native focus to header on header cell click', () => {
       const tabbableElements = getTabbableElements(grid.shadowRoot);
       focusFirstHeaderCell();