diff --git a/vyper/context/types/function.py b/vyper/context/types/function.py
index 4fb80d8a6d..7e20be631a 100644
--- a/vyper/context/types/function.py
+++ b/vyper/context/types/function.py
@@ -7,6 +7,7 @@
 from vyper.context.namespace import get_namespace
 from vyper.context.types.bases import BaseTypeDefinition, DataLocation
 from vyper.context.types.indexable.sequence import TupleDefinition
+from vyper.context.types.meta.struct import StructDefinition
 from vyper.context.types.utils import (
     StringEnum,
     check_constant,
@@ -290,6 +291,11 @@ def from_FunctionDef(
             type_definition = get_type_from_annotation(
                 arg.annotation, location=DataLocation.CALLDATA, is_immutable=True
             )
+            if isinstance(type_definition, StructDefinition) and type_definition.is_dynamic_size:
+                raise ArgumentException(
+                    "Struct with dynamically sized data cannot be used as a function input", arg
+                )
+
             if value is not None:
                 if not check_constant(value):
                     raise StateAccessViolation(