diff --git a/packages/desktop-cli/package.json b/packages/desktop-cli/package.json
index 028588977..079168f81 100644
--- a/packages/desktop-cli/package.json
+++ b/packages/desktop-cli/package.json
@@ -1,10 +1,5 @@
 {
   "name": "@stlite/desktop-cli",
   "version": "0.23.0",
-  "license": "Apache-2.0",
-  "dependencies": {
-    "@stlite/desktop": "^0.23.0",
-    "node-fetch": "2",
-    "pyodide": "^0.21.3"
-  }
+  "license": "Apache-2.0"
 }
diff --git a/packages/desktop/package.json b/packages/desktop/package.json
index aac6448b3..295d61410 100644
--- a/packages/desktop/package.json
+++ b/packages/desktop/package.json
@@ -19,7 +19,7 @@
     "eject": "craco eject",
     "start:electron": "tsc -p electron -w",
     "build:electron": "tsc -p electron",
-    "build:pyodide": "curl -L https://github.com/pyodide/pyodide/releases/download/0.21.3/pyodide-build-0.21.3.tar.bz2 | tar xj -C ./build --files-from=./pyodide-files.txt",
+    "build:pyodide": "curl -L https://github.com/pyodide/pyodide/releases/download/0.22.1/pyodide-0.22.1.tar.bz2 | tar xj -C ./build --files-from=./pyodide-files.txt",
     "build:bin": "./scripts/build_bin.js && sed -i'' -e '1 s/^#!.*$/#!\\/usr\\/bin\\/env node/' ./bin/*.js",
     "typecheck": "yarn tsc --noEmit -p electron",
     "start": "concurrently \"cross-env BROWSER=none yarn start:web\" \"wait-on http://localhost:3000 && yarn start:electron\" \"wait-on http://localhost:3000 && tsc -p electron && cross-env NODE_ENV=\"development\" electron .\"",
@@ -52,7 +52,7 @@
   "dependencies": {
     "fs-extra": "^10.1.0",
     "node-fetch": "2",
-    "pyodide": "^0.21.3",
+    "pyodide": "0.22.1",
     "yargs": "^17.5.1"
   },
   "devDependencies": {
diff --git a/packages/desktop/pyodide-files.txt b/packages/desktop/pyodide-files.txt
index 7c02605b2..391d53bd5 100644
--- a/packages/desktop/pyodide-files.txt
+++ b/packages/desktop/pyodide-files.txt
@@ -1,4 +1,3 @@
-pyodide/distutils.tar
 pyodide/openssl-1.1.1n.zip
 pyodide/pyodide.asm.data
 pyodide/pyodide.asm.js
diff --git a/packages/kernel/package.json b/packages/kernel/package.json
index d5eb536c6..d6e6a27b9 100644
--- a/packages/kernel/package.json
+++ b/packages/kernel/package.json
@@ -26,7 +26,7 @@
     "eslint": "^8.21.0",
     "eslint-plugin-react": "^7.30.1",
     "eslint-plugin-react-hooks": "^4.6.0",
-    "pyodide": "^0.21.3",
+    "pyodide": "0.22.1",
     "typescript": "^4.6.4",
     "vitest": "^0.21.1"
   },
diff --git a/packages/kernel/src/worker.ts b/packages/kernel/src/worker.ts
index d0ae137ec..52637f9ba 100644
--- a/packages/kernel/src/worker.ts
+++ b/packages/kernel/src/worker.ts
@@ -50,7 +50,7 @@ async function loadPyodideAndPackages() {
   console.debug("Import the entrypoint script.");
   importScripts(
     pyodideEntrypointUrl ??
-      "https://cdn.jsdelivr.net/pyodide/v0.21.3/full/pyodide.js"
+      "https://cdn.jsdelivr.net/pyodide/v0.22.1/full/pyodide.js"
   );
 
   console.debug("Loading Pyodide");
diff --git a/yarn.lock b/yarn.lock
index 058e8c189..5e8e0031f 100644
--- a/yarn.lock
+++ b/yarn.lock
@@ -19732,10 +19732,10 @@ pxls@^2.0.0:
     is-buffer "^2.0.3"
     to-uint8 "^1.4.1"
 
-pyodide@^0.21.3:
-  version "0.21.3"
-  resolved "https://registry.yarnpkg.com/pyodide/-/pyodide-0.21.3.tgz#0be64868231fa59a5372a1191d157a9e8d83e9d7"
-  integrity sha512-5fu5P8ys8V8tKTsK9lag0HattbZQuFRdnNzv1LLOLCieM9A96OPs2cF29lPpcD9N+8GuUtfrGCWEMKiupTHUlA==
+pyodide@0.22.1:
+  version "0.22.1"
+  resolved "https://registry.yarnpkg.com/pyodide/-/pyodide-0.22.1.tgz#45bfab36ef332ec7fed6fb9736ab13ebd54f05d1"
+  integrity sha512-6+PkFLTC+kcBKtFQxYBxR44J5IBxLm8UGkobLgZv1SxzV9qOU2rb0YYf0qDtlnfDiN/IQd2uckf+D8Zwe88Mqg==
   dependencies:
     base-64 "^1.0.0"
     node-fetch "^2.6.1"