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We study a new mathematical model of a hormonal axis that comprises two coupled ultradian pulse generators. One generator is located in the hypothalamus, the second is located in the anterior pituitary. Two integrate-and-fire schemes are used to describe the pulse generator mechanisms. Depending on their firing thresholds and on the coupling gains, the system exhibits a variety of periodic or quasi-periodic behaviors.
Arrows and bar-headed lines indicate excitatory and inhibitory connections, respectively.
Here
Let
with the clearance coefficient
Let
where
Between the impulses in membrane potential satisfies the differential equation
where
The secretion rate
where
Here
These equations define a mapping
with a vector of parameters
Let
Use a pulse generator described in the previous section with a vector of parameters
The input function
\end{equation}
and contains two components: a modulating input,
where
Consider the pulse generator with a vector of parameters
The input function
where
Suppose that the target hormone is released continuously, following a linear differential equation
where
The depository contains a MATLAB program for simulating and drawing hormonal profiles. The simulations are illustrated with figures pic01.png, pic02.png, pic03.png given in Images folder.