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6. <<faq-H6,What are the risks of subject identification associated with sharing of summary statistics?>> | ||
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7. <<faq-H7,Why do some datasets have the CC0 license mark?>> | ||
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=== I. Submitting summary statistics | ||
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1. <<faq-I1,How can I submit summary statistics to the GWAS Catalog?>> | ||
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Currently the feeling in the community is that the unrestricted sharing of summary statistics holds a great deal of potential benefits, with low risk to participants’ privacy. A study by Homer et al., (PMID:18769715) in 2008 indicated that it was possible to determine if a specific individual participated in a study based on summary-level statistics (including allele frequencies of the study participants) and the genotype information of the individual. However, this would require that an individual had made public their genotype information, and also participated in a study for which summary-level allele frequencies were available. Since this publication there has been widespread discussion in the scientific community, along with several publications (including Craig et al., 2011, PMID:21921928) on the benefits and risks surrounding sharing of summary statistics. After considering the risks and benefits the NIH has published guidance supporting open sharing of summary statistics information, including allele frequencies (https://osp.od.nih.gov/2018/11/01/provide-access-gsr/, https://grants.nih.gov/grants/guide/notice-files/NOT-OD-19-023.html). | ||
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==== [[faq-H7]]7. Why do some datasets have the CC0 license mark? | ||
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From March 2021, we are asking all submitters to agree to share their data under the terms of https://creativecommons.org/publicdomain/zero/1.0/[CC0]. This dedicates the data to the public domain, allowing downstream users to consume the data without restriction. Data submitted prior to March 2021 is made available under the https://www.ebi.ac.uk/about/terms-of-use/[EBI standard terms of use]. Whilst these terms do not themselves impose any restrictions on downstream use, the application of CC0 license removes any ambiguity. We advise consumers of data hosted by the GWAS Catalog to note the license terms of individual datasets, if applicable to their specific use case. Please ensure that the original data are cited whenever they are used in a publication. | ||
If you have any questions or concerns about licensing, please contact us via [email protected]. | ||
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== [[I]]I. Submitting summary statistics | ||
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==== [[faq-I1]]1. How can I submit summary statistics to the GWAS Catalog? | ||
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''' | ||
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_Last updated: 28 May 2020_ | ||
_Last updated: 16 March 2021_ |
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@@ -19,15 +19,16 @@ The GWAS Catalog accepts summary statistics for both published and unpublished h | |
2. <<link-6, Install Globus Connect Personal>> | ||
3. <<link-7, Enter registered Globus email>> | ||
4. <<link-8, Format and validate summary statistics>> | ||
5. <<link-9, Create submission>> | ||
5. <<link-9, License agreement>> | ||
6. <<link-10, Create submission>> | ||
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<<C, C. Uploading data>> | ||
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1. <<link-10, Upload summary statistics>> | ||
2. <<link-11, Download submission form>> | ||
3. <<link-12, Fill in submission form>> | ||
4. <<link-13, Submit submission form>> | ||
5. <<link-14, After submission>> | ||
1. <<link-11, Upload summary statistics>> | ||
2. <<link-12, Download submission form>> | ||
3. <<link-13, Fill in submission form>> | ||
4. <<link-14, Submit submission form>> | ||
5. <<link-15, After submission>> | ||
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<<D, Additional information>> | ||
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Enter the email address associated with your Globus account. It should be filled automatically, but you can change it if needed. | ||
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image::enter_email.png[Enter Globus email,width=800,align="center"] | ||
image::enter_email2.png[Enter Globus email,width=800,align="center"] | ||
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{empty} | ||
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=== [[link-8]]4. Format and validate summary statistics | ||
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Please confirm that your summary statistics files conform to our standard format and content, otherwise your submission will fail validation. If you haven’t already done so, follow the https://www.ebi.ac.uk/gwas/docs/summary-statistics-format[Format and validate link^] for formatting instructions and to access our offline summary statistics validator. | ||
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=== [[link-9]]5. Create submission | ||
=== [[link-9]]5. License agreement | ||
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From March 2021, we are asking all submitters to agree to share their data under the terms of https://creativecommons.org/publicdomain/zero/1.0[CC0]. This dedicates your data to the public domain, allowing downstream users to consume the data without restriction. This unambiguous declaration of free and open access is required for some downstream uses, e.g. to meet the data sharing requirements of certain journals, and maximise the utility of your data to the research community. Data submitted prior to March 2021 is made available under the EBI standard https://www.ebi.ac.uk/about/terms-of-use[terms of use]. Whilst these terms do not themselves impose any restrictions on downstream use, the application of CC0 license removes any ambiguity. We advise consumers of data hosted by the GWAS Catalog to note the license terms of individual datasets, if applicable to their specific use case. Please ensure that the original data are cited whenever they are used in a publication. | ||
If you have any questions or concerns about licensing, please contact us via [email protected]. | ||
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=== [[link-10]]6. Create submission | ||
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Please tick each box in the checklist to confirm that the prerequisites have been completed. | ||
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After you have created a submission, you will be able to upload your summary statistics and supporting information. | ||
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=== [[link-10]]1. Upload summary statistics | ||
=== [[link-11]]1. Upload summary statistics | ||
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The first step is to upload your summary statistics files. When you create a submission, a folder is created for you. You can transfer your summary statistics to this location using Globus. | ||
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A message will appear when the transfer request has successfully started. Large files may take some time to transfer, but you do not need to wait until this is finished - the transfer will continue in the background while you proceed with the next step. You do however need to wait for confirmation of file transfer before clicking "Submit submission form" (step 3). | ||
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=== [[link-11]]2. Download submission form | ||
=== [[link-12]]2. Download submission form | ||
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You will now need to provide some additional information to support the summary statistics files. | ||
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Please download a new form each time you create a new submission for a publication, to make sure you have the most correct and up-to-date form for your specific submission. | ||
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=== [[link-12]]3. Fill in submission form | ||
=== [[link-13]]3. Fill in submission form | ||
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For help filling in the submission form, follow the link from the submission interface, or select the relevant link below: | ||
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1. Instructions for https://www.ebi.ac.uk/gwas/docs/submission-summary-statistics[summary statistics only^], or | ||
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2. Instructions for https://www.ebi.ac.uk/gwas/docs/submission-summary-statistics-plus-metadata[summary statistics plus study metadata^] | ||
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=== [[link-13]]4. Submit submission form | ||
=== [[link-14]]4. Submit submission form | ||
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Once you have completed the submission form, save it and click "Submit submission form". | ||
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image::review_reset.png[Review or reset,width=300,align="center"] | ||
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=== [[link-14]]5. After submission | ||
=== [[link-15]]5. After submission | ||
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After submission, you will be taken to the My Submissions page (see below), where you can see your latest submission, now with the status SUBMITTED. | ||
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