ClaraGenomicsAnalysis 0.5.0 - Release Candidate 1

Release candidate for v0.5.0 focuses primarily on improving the performance of the GPU accelerated mapper, cudamapper . Here are some highlights of this release so far -

1. CUDA Mapper

• Enabled filtering of high frequency sketch elements in index (-F option. More details highlighted in help message)
• Host and device caching for improved indexer performance (-C and -c)
• Smart cached memory allocator for improved device memory initialization time
• Re-architected matcher/overlapper components to improve end to end performance
• Algorithmic improvements to overlapper leader to higher accuracy of overlaps

Application	dataset	GPU	v0.4.3	v0.5.0-rc1	Acceleration
cudamapper all-vs-all	ONT E. Coli 150x	1x GV100 32GB	72.3s	23.2s	3.11x