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@@ -28,7 +28,7 @@ | |
import java.util.stream.Collectors; | ||
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/** | ||
* Determine the baseline contig ploidy for germline samples given counts data. | ||
* Determines the baseline contig ploidy for germline samples given counts data. | ||
* These should be either HDF5 or TSV count files generated by {@link CollectFragmentCounts}. | ||
* | ||
* <p> | ||
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@@ -99,7 +99,7 @@ | |
* | ||
* <p>COHORT mode:</p> | ||
* <pre> | ||
* gatk --javaOptions "-Xmx4g" DetermineGermlineContigPloidy \ | ||
* gatk DetermineGermlineContigPloidy \ | ||
* --input normal_1.counts.hdf5 \ | ||
* --input normal_2.counts.hdf5 \ | ||
* ... \ | ||
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* | ||
* <p>CASE mode:</p> | ||
* <pre> | ||
* gatk --javaOptions "-Xmx4g" DetermineGermlineContigPloidy \ | ||
* gatk DetermineGermlineContigPloidy \ | ||
* --model a_valid_ploidy_model_dir | ||
* --input normal_1.counts.hdf5 \ | ||
* --input normal_2.counts.hdf5 \ | ||
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@@ -123,8 +123,8 @@ | |
* @author Samuel Lee <[email protected]> | ||
*/ | ||
@CommandLineProgramProperties( | ||
summary = "Determine the baseline contig ploidy for germline samples given counts data.", | ||
oneLineSummary = "Determine the baseline contig ploidy for germline samples given counts data.", | ||
summary = "Determines the baseline contig ploidy for germline samples given counts data.", | ||
oneLineSummary = "Determines the baseline contig ploidy for germline samples given counts data.", | ||
programGroup = CopyNumberProgramGroup.class | ||
) | ||
@DocumentedFeature | ||
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import java.util.stream.Collectors; | ||
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/** | ||
* Call copy-number variants in germline samples given their counts and the corresponding output of | ||
* Calls copy-number variants in germline samples given their counts and the corresponding output of | ||
* {@link DetermineGermlineContigPloidy}. The former should be either HDF5 or TSV count files generated by | ||
* {@link CollectFragmentCounts}. | ||
* | ||
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@@ -108,15 +108,15 @@ | |
* the python subprocess. Generally speaking, the resource requirements of this tool scale linearly with each of the | ||
* number of samples, the number of modeled intervals, the highest copy number state, the number of bias factors, and | ||
* the number of knobs on the GC curve. For example, the python subprocess requires approximately 16gb for RAM for | ||
* modeling 10'000 intervals for 100 samples, with 16 maximum bias factors and explicit GC bias modeling. | ||
* modeling 10000 intervals for 100 samples, with 16 maximum bias factors and explicit GC bias modeling. | ||
* </p></dd> | ||
* </dl> | ||
* | ||
* <h3>Usage examples</h3> | ||
* | ||
* <p>COHORT mode:</p> | ||
* <pre> | ||
* gatk --javaOptions "-Xmx4g" GermlineCNVCaller \ | ||
* gatk GermlineCNVCaller \ | ||
* --run-mode COHORT \ | ||
* -L intervals.interval_list \ | ||
* --contig-ploidy-calls path_to_contig_ploidy_calls | ||
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@@ -129,7 +129,7 @@ | |
* | ||
* <p>CASE mode:</p> | ||
* <pre> | ||
* gatk --javaOptions "-Xmx4g" GermlineCNVCaller \ | ||
* gatk GermlineCNVCaller \ | ||
* --run-mode CASE \ | ||
* -L intervals.interval_list \ | ||
* --contig-ploidy-calls path_to_contig_ploidy_calls | ||
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@@ -144,9 +144,9 @@ | |
* @author Samuel Lee <[email protected]> | ||
*/ | ||
@CommandLineProgramProperties( | ||
summary = "Denoise and call copy-number variants in germline samples given their counts and " + | ||
summary = "Calls copy-number variants in germline samples given their counts and " + | ||
"the output of DetermineGermlineContigPloidy.", | ||
oneLineSummary = "Denoise and call copy-number variants in germline samples given their counts and " + | ||
oneLineSummary = "Calls copy-number variants in germline samples given their counts and " + | ||
"the output of DetermineGermlineContigPloidy.", | ||
programGroup = CopyNumberProgramGroup.class | ||
) | ||
|