highly variable gene annotation

api/python/cellxgene_census/pyproject.toml

@@ -47,6 +47,7 @@ experimental = [
     "torch==2.0.1",
     "torchdata==0.6.1",
     "scikit-learn==1.2.2",
+    "scikit-misc==0.2.0",
 ]
 
 [project.urls]

api/python/cellxgene_census/src/cellxgene_census/_get_anndata.py

@@ -10,13 +10,8 @@
 
 import anndata
 import tiledbsoma as soma
-
-# TODO: waiting on https://github.com/single-cell-data/TileDB-SOMA/issues/872.
 from somacore.options import SparseDFCoord
 
-# TODO: rm this import and use `soma.AxisColumnNames` after https://github.com/single-cell-data/TileDB-SOMA/issues/791
-from somacore.query.query import AxisColumnNames
-
 from ._experiment import _get_experiment
 
 
@@ -29,7 +24,7 @@ def get_anndata(
     obs_coords: Optional[SparseDFCoord] = None,
     var_value_filter: Optional[str] = None,
     var_coords: Optional[SparseDFCoord] = None,
-    column_names: Optional[AxisColumnNames] = None,
+    column_names: Optional[soma.AxisColumnNames] = None,
 ) -> anndata.AnnData:
     """
     Convience wrapper around ``soma.Experiment`` query, to build and execute a query,

api/python/cellxgene_census/src/cellxgene_census/experimental/pp/__init__.py

@@ -0,0 +1,6 @@
+from ._highly_variable_genes import get_highly_variable_genes, highly_variable_genes
+
+__all__ = [
+    "get_highly_variable_genes",
+    "highly_variable_genes",
+]

api/python/cellxgene_census/src/cellxgene_census/experimental/pp/_eager_iter.py

@@ -0,0 +1,92 @@
+import threading
+from collections import deque
+from concurrent import futures
+from typing import Deque, Iterator, Optional, TypeVar
+
+_T = TypeVar("_T")
+
+
+class EagerIterator(Iterator[_T]):
+    def __init__(
+        self,
+        iterator: Iterator[_T],
+        pool: Optional[futures.Executor] = None,
+    ):
+        super().__init__()
+        self.iterator = iterator
+        self._pool = pool or futures.ThreadPoolExecutor()
+        self._own_pool = pool is None
+        self._future = self._pool.submit(self.iterator.__next__)
+
+    def __next__(self) -> _T:
+        try:
+            res = self._future.result()
+            self._future = self._pool.submit(self.iterator.__next__)
+            return res
+        except StopIteration:
+            self._cleanup()
+            raise
+
+    def _cleanup(self) -> None:
+        if self._own_pool:
+            self._pool.shutdown()
+
+    def __del__(self) -> None:
+        # Ensure the threadpool is cleaned up in the case where the
+        # iterator is not exhausted. For more information on __del__:
+        # https://docs.python.org/3/reference/datamodel.html#object.__del__
+        self._cleanup()
+        super_del = getattr(super(), "__del__", lambda: None)
+        super_del()
+
+
+class EagerBufferedIterator(Iterator[_T]):
+    def __init__(
+        self,
+        iterator: Iterator[_T],
+        max_pending: int = 1,
+        pool: Optional[futures.Executor] = None,
+    ):
+        super().__init__()
+        self.iterator = iterator
+        self.max_pending = max_pending
+        self._pool = pool or futures.ThreadPoolExecutor()
+        self._own_pool = pool is None
+        self._pending_results: Deque[futures.Future[_T]] = deque()
+        self._lock = threading.Lock()
+        self._begin_next()
+
+    def __next__(self) -> _T:
+        try:
+            res = self._pending_results[0].result()
+            self._pending_results.popleft()
+            self._begin_next()
+            return res
+        except StopIteration:
+            self._cleanup()
+            raise
+
+    def _begin_next(self) -> None:
+        def _fut_done(fut: futures.Future[_T]) -> None:
+            if fut.exception() is None:
+                self._begin_next()
+
+        with self._lock:
+            not_running = len(self._pending_results) == 0 or self._pending_results[-1].done()
+            if len(self._pending_results) < self.max_pending and not_running:
+                _future = self._pool.submit(self.iterator.__next__)
+                _future.add_done_callback(_fut_done)
+                self._pending_results.append(_future)
+            assert len(self._pending_results) <= self.max_pending
+
+    def _cleanup(self) -> None:
+        if self._own_pool:
+            self._pool.shutdown()
+
+    def __del__(self) -> None:
+        # Ensure the threadpool is cleaned up in the case where the
+        # iterator is not exhausted. For more information on __del__:
+        # https://docs.python.org/3/reference/datamodel.html#object.__del__
+        self._cleanup()
+        super_del = getattr(super(), "__del__", lambda: None)
+        super_del()