BA.2 (+22792T) with S:1261Y [848 in Denmark, 1129 global]

[olias120676]

Slowly growing (12% growth advantage per week) BA.2 (+22792T) with S:1261Y (C25344A).

Appears to have started circulating in Denmark since late 2021, then spreading beyond from February 2022 onwards.

https://cov-spectrum.org/explore/World/AllSamples/Past6M/variants?nucMutations=C25344A%2C22792T&pangoLineage=BA.2*

Earliest sequence:-
Denmark/DCGC-316814/2021 | EPI_ISL_8834149

Within this subtree there are a a couple of spike mutations at 248, S:Y248H (T22304C) and S:Y248S (A22305C).

The S:Y248H branch seems more notable, with 432 sequences and growth advantage in Denmark currently showing as 29% per week

EPI_ISL list

USHER tree

[FedeGueli]

Good catch @olias120676 ! it seems that the growth advantage of the sublineage with S:248H in England is above 40%, that is interesting considering the circulation of quite every new high trasmissible lineage there.

[Sinickle]

S:248S has also appeared in the UK and the USA 600 times between the two of them, and has a similarly large growth advantage over BA.2.

Edit: @corneliusroemer has now fleshed this out in #634.

[corneliusroemer]

I'd probably focus on the 248H contained within. Not sure how much S:1261T does on its own.

[corneliusroemer]

S:248H makes up (almost) all of the sequences of the S:1261Y lineage by now.

[InfrPopGen]

Thanks for submitting. We've added lineage BA.2.47 with 803 newly designated sequences, and 45 updated designations from BA.2. Defining mutation(s) T22304C (S:Y248H).