BA.5.1 Sublineage with 3 base insertion in spike S:1246:C and ORF1b:V1170I

[kdurkin]

Proposal for a sublineage of BA.5.1
Earliest sequence: 2022-07-11 (France)
Countries detected: France, Belgium, Israel, Denmark

Defining mutation:
G16975A = ORF1b:V1170I
ins25300:TGC = S:1246:C

Subvariant is defined by an insertion in the cytoplasmic tail of spike (ins25300:TGC = S:1246:C) as well as ORF1b:V1170I

Observed in 18 samples
17 from UShER 24/08/2022
(EPI_ISL_14247473, EPI_ISL_14439367, EPI_ISL_14484968, EPI_ISL_14562933, EPI_ISL_14168239, EPI_ISL_14578232, EPI_ISL_14388076, EPI_ISL_14304371, EPI_ISL_14198362, EPI_ISL_14074362, EPI_ISL_13953991, EPI_ISL_14527765, EPI_ISL_14433078, EPI_ISL_14554467, EPI_ISL_14198286, EPI_ISL_14169451, EPI_ISL_14169424)
Additional example (EPI_ISL_14607947) uploaded to GISAID 24/08/2022

https://nextstrain.org/fetch/genome.ucsc.edu/trash/ct/subtreeAuspice1_genome_123ed_6298a0.json?label=nuc%20mutations:G16975A

https://cov-spectrum.org/explore/World/AllSamples/Past6M/variants?aaMutations=ORF1b%3AV1170I&aaInsertions=ins_S%3A1246%3AC&pangoLineage=BA.5.1&

[InfrPopGen]

Thanks for submitting. We've added lineage BA.5.1.31 with 31 newly designated sequences, and 1 updated designations from BA.5.1. Defining mutation G16975A (ORF1b:V1170I) (following A5317G, C12853T, C26636T, C28435T).