Tools to process and analyze the Socal Kinesia and Incentivization for Parkinson's Disease (SKIP) highres FC datset: https://doi.org/10.18112/openneuro.ds005264.v1.0.0
More information about SKIP can be found here: https://socalkinesia.org/
Repository contains code and mask collection for mapping open- and closed-loop motor networks at rest with ultra-high field, multi-echo EPI data. This resource was used to generate results for: Rizor et al., 2024, Dissociation of putative open loop circuit from ventral putamen to motor cortical areas in humans I: high-resolution connectomics. For information on how to process data using this code, please refer to script_pipeline.txt
If used, please cite:
Rizor, E., Dundon, N. M., Wang, J., Stasiak, J., Li, T., Bostan, A. C., Lapate, R. C., & Grafton, S. T. (2024). Dissociation of novel open loop from ventral putamen to motor areas from classic closed loop in humans I: high-resolution connectomics. bioRxiv. https://doi.org/10.1101/2024.08.28.610129
Dundon, N. M., Rizor, E., Stasiak, J., Wang, J., Sabugo, K., Villaneuva, C., Barandon, P., Bostan, A. C., Lapate, R. C., & Grafton, S. T. (2024). Dissociation of novel open loop from ventral putamen to motor areas from classic closed loop in humans II: Task-based function. bioRxiv, 2024-06.
In non-human primates, separable "open-loop" and "closed-loop" motor circuits have been identified via rabies virus tracing (Kelly & Strick, 2004). In Parkinson's Disease (PD), the closed-loop is compromised via degredation of the dorsal putamen connectivity. Preserved open-loop circuitry in the human brain may explain paradoxical kinesia, or the phenomenon where PD patients display enhanced movement in emotionally arousing situations. If identified in humans, the open-loop circuit may be a potential target for PD therapy.
Posited open-loop circuit:
This research was funded in whole (or in part) by Aligning Science Across Parkinson's ASAP-020-519 through the Michael J. Fox Foundation for Parkinson's Research (MJFF).